Genular: Defining Cellular Identity and Function

Details for: Cd40

Gene ID: 21939

Symbol: Cd40

Ensembl ID: ENSMUSG00000017652

Description: CD40 antigen

Associated with

Adaptive immune system
(R-MMU-1280218)
Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-MMU-198933)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
(R-MMU-5676594)
Antigen binding
(GO:0003823)
B cell activation
(GO:0042113)
B cell mediated immunity
(GO:0019724)
B cell proliferation
(GO:0042100)
Cd40 receptor complex
(GO:0035631)
Cd40 signaling pathway
(GO:0023035)
Cell surface
(GO:0009986)
Defense response to protozoan
(GO:0042832)
Defense response to virus
(GO:0051607)
Enzyme binding
(GO:0019899)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Immune response-regulating cell surface receptor signaling pathway
(GO:0002768)
Immune system process
(GO:0002376)
Immunoglobulin production
(GO:0002377)
Interleukin-12 production
(GO:0032615)
Intracellular calcium ion homeostasis
(GO:0006874)
Intracellular membrane-bounded organelle
(GO:0043231)
Membrane
(GO:0016020)
Neuronal cell body
(GO:0043025)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Plasma membrane
(GO:0005886)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of endothelial cell apoptotic process
(GO:2000353)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of isotype switching to igg isotypes
(GO:0048304)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of protein kinase c signaling
(GO:0090037)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Regulation of immune response
(GO:0050776)
Regulation of immunoglobulin production
(GO:0002637)
Signaling receptor activity
(GO:0038023)
Ubiquitin protein ligase binding
(GO:0031625)
Varicosity
(GO:0043196)

Other Information

Proteins

Tumor necrosis factor receptor superfamily member 5

Genular Protein ID: 3197447443

Symbol: TNR5_MOUSE

Name: Tumor necrosis factor receptor superfamily member 5

UniProtKB Accession Codes:

P27512 Q3TS33 Q3TSL2 Q3U799 Q3U7C9 Q3UBH3 Q542B1 Q8K2X6 Q99NE0 Q99NE1 Q99NE2 Q99NE3

Database IDs:

Citations:

PubMed ID: 1370315

Title: Differential increase of an alternatively polyadenylated mRNA species of murine CD40 upon B lymphocyte activation.

PubMed ID: 1370315

PubMed ID: 1281194

Title: Genomic structure and chromosomal mapping of the murine CD40 gene.

PubMed ID: 1281194

PubMed ID: 11172023

Title: Regulation of CD40 function by its isoforms generated through alternative splicing.

PubMed ID: 11172023

DOI: 10.1073/pnas.98.4.1751

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7533327

Title: Involvement of CRAF1, a relative of TRAF, in CD40 signaling.

PubMed ID: 7533327

DOI: 10.1126/science.7533327

PubMed ID: 8790348

Title: TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling.

PubMed ID: 8790348

DOI: 10.1073/pnas.93.18.9437

PubMed ID: 12881420

Title: Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.

PubMed ID: 12881420

DOI: 10.1093/emboj/cdg386

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 289
Mass: 32093
Checksum: C7970DAD2FEA534A
Sequence:

MVSLPRLCAL WGCLLTAVHL GQCVTCSDKQ YLHDGQCCDL CQPGSRLTSH CTALEKTQCH 
PCDSGEFSAQ WNREIRCHQH RHCEPNQGLR VKKEGTAESD TVCTCKEGQH CTSKDCEACA 
QHTPCIPGFG VMEMATETTD TVCHPCPVGF FSNQSSLFEK CYPWTSCEDK NLEVLQKGTS 
QTNVICGLKS RMRALLVIPV VMGILITIFG VFLYIKKVVK KPKDNEILPP AARRQDPQEM 
EDYPGHNTAA PVQETLHGCQ PVTQEDGKES RISVQERQVT DSIALRPLV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cd40

Associated with

Other Information

Differential increase of an alternatively polyadenylated mRNA species of murine CD40 upon B lymphocyte activation. PubMed ID: 1370315

Genomic structure and chromosomal mapping of the murine CD40 gene. PubMed ID: 1281194

Regulation of CD40 function by its isoforms generated through alternative splicing. PubMed ID: 11172023

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Involvement of CRAF1, a relative of TRAF, in CD40 signaling. PubMed ID: 7533327

TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. PubMed ID: 8790348

Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40. PubMed ID: 12881420

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079