Genular: Defining Cellular Identity and Function

Details for: Tnfsf11

Gene ID: 21943

Symbol: Tnfsf11

Ensembl ID: ENSMUSG00000022015

Description: tumor necrosis factor (ligand) superfamily, member 11

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
(R-MMU-5676594)
Tnfs bind their physiological receptors
(R-MMU-5669034)
Animal organ morphogenesis
(GO:0009887)
Bone development
(GO:0060348)
Bone resorption
(GO:0045453)
Calcium-mediated signaling
(GO:0019722)
Calcium ion homeostasis
(GO:0055074)
Cell differentiation
(GO:0030154)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine activity
(GO:0005125)
Cytoplasm
(GO:0005737)
Erk1 and erk2 cascade
(GO:0070371)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Jnk cascade
(GO:0007254)
Lymph node development
(GO:0048535)
Mammary gland alveolus development
(GO:0060749)
Mammary gland epithelial cell proliferation
(GO:0033598)
Membrane
(GO:0016020)
Monocyte chemotaxis
(GO:0002548)
Multicellular organism development
(GO:0007275)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Ossification
(GO:0001503)
Osteoclast development
(GO:0036035)
Osteoclast differentiation
(GO:0030316)
Osteoclast proliferation
(GO:0002158)
Paracrine signaling
(GO:0038001)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Plasma membrane
(GO:0005886)
Positive regulation of bone resorption
(GO:0045780)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of corticotropin-releasing hormone secretion
(GO:0051466)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of fever generation by positive regulation of prostaglandin secretion
(GO:0071812)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of homotypic cell-cell adhesion
(GO:0034112)
Positive regulation of intracellular signal transduction
(GO:1902533)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of osteoclast development
(GO:2001206)
Positive regulation of osteoclast differentiation
(GO:0045672)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of t cell activation
(GO:0050870)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Regulation of actin binding
(GO:1904616)
Regulation of osteoclast differentiation
(GO:0045670)
Tooth eruption
(GO:0044691)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Tumor necrosis factor receptor binding
(GO:0005164)
Tumor necrosis factor receptor superfamily binding
(GO:0032813)

Other Information

Proteins

Tumor necrosis factor ligand superfamily member 11

Genular Protein ID: 1747360425

Symbol: TNF11_MOUSE

Name: Tumor necrosis factor ligand superfamily member 11

UniProtKB Accession Codes:

O35235 O35306 Q3TWY5 Q9JJK8 Q9JJK9 Q9R1Y0

Database IDs:

Citations:

PubMed ID: 9312132

Title: TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells.

PubMed ID: 9312132

DOI: 10.1074/jbc.272.40.25190

PubMed ID: 9367155

Title: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.

PubMed ID: 9367155

DOI: 10.1038/36593

PubMed ID: 9568710

Title: Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.

PubMed ID: 9568710

DOI: 10.1016/s0092-8674(00)81569-x

PubMed ID: 9520411

Title: Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL.

PubMed ID: 9520411

DOI: 10.1073/pnas.95.7.3597

PubMed ID: 10196481

Title: Cloning and characterization of the gene encoding mouse osteoclast differentiation factor.

PubMed ID: 10196481

DOI: 10.1016/s0378-1119(99)00025-6

PubMed ID: 11250921

Title: Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymus.

PubMed ID: 11250921

DOI: 10.1210/endo.142.4.8070

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10224132

Title: Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival.

PubMed ID: 10224132

DOI: 10.1074/jbc.274.19.13613

PubMed ID: 18586671

Title: TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation.

PubMed ID: 18586671

DOI: 10.1074/jbc.m802138200

PubMed ID: 22437732

Title: Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation.

PubMed ID: 22437732

DOI: 10.1002/jbmr.1600

PubMed ID: 23395171

Title: Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation.

PubMed ID: 23395171

DOI: 10.1016/j.cmet.2013.01.002

PubMed ID: 24039232

Title: Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism.

PubMed ID: 24039232

DOI: 10.1242/jcs.127571

PubMed ID: 26644563

Title: Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass.

PubMed ID: 26644563

DOI: 10.1073/pnas.1511285112

PubMed ID: 27336669

Title: Identification of Nedd9 as a TGF-beta-Smad2/3 Target Gene Involved in RANKL-Induced Osteoclastogenesis by Comprehensive Analysis.

PubMed ID: 27336669

DOI: 10.1371/journal.pone.0157992

PubMed ID: 11581298

Title: Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity.

PubMed ID: 11581298

DOI: 10.1172/jci13890

PubMed ID: 11733492

Title: Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution.

PubMed ID: 11733492

DOI: 10.1074/jbc.m106525200

PubMed ID: 20483727

Title: Structural and functional insights of RANKL-RANK interaction and signaling.

PubMed ID: 20483727

DOI: 10.4049/jimmunol.0904033

PubMed ID: 23039992

Title: RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor.

PubMed ID: 23039992

DOI: 10.1016/j.str.2012.08.030

Sequence Information:

Length: 316
Mass: 35003
Checksum: 8AF3825F92E0A786
Sequence:

MRRASRDYGK YLRSSEEMGS GPGVPHEGPL HPAPSAPAPA PPPAASRSMF LALLGLGLGQ 
VVCSIALFLY FRAQMDPNRI SEDSTHCFYR ILRLHENADL QDSTLESEDT LPDSCRRMKQ 
AFQGAVQKEL QHIVGPQRFS GAPAMMEGSW LDVAQRGKPE AQPFAHLTIN AASIPSGSHK 
VTLSSWYHDR GWAKISNMTL SNGKLRVNQD GFYYLYANIC FRHHETSGSV PTDYLQLMVY 
VVKTSIKIPS SHNLMKGGST KNWSGNSEFH FYSINVGGFF KLRAGEEISI QVSNPSLLDP 
DQDATYFGAF KVQDID

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tnfsf11

Associated with

Other Information

TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. PubMed ID: 9312132

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. PubMed ID: 9367155

Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. PubMed ID: 9568710

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. PubMed ID: 9520411

Cloning and characterization of the gene encoding mouse osteoclast differentiation factor. PubMed ID: 10196481

Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymus. PubMed ID: 11250921

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival. PubMed ID: 10224132

TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation. PubMed ID: 18586671

Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation. PubMed ID: 22437732

Tmem64 modulates calcium signaling during RANKL-mediated osteoclast differentiation. PubMed ID: 23395171

Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism. PubMed ID: 24039232

Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass. PubMed ID: 26644563

Identification of Nedd9 as a TGF-beta-Smad2/3 Target Gene Involved in RANKL-Induced Osteoclastogenesis by Comprehensive Analysis. PubMed ID: 27336669

Crystal structure of the TRANCE/RANKL cytokine reveals determinants of receptor-ligand specificity. PubMed ID: 11581298

Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolution. PubMed ID: 11733492

Structural and functional insights of RANKL-RANK interaction and signaling. PubMed ID: 20483727

RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor. PubMed ID: 23039992