Genular: Defining Cellular Identity and Function

Details for: Cd40lg

Gene ID: 21947

Symbol: Cd40lg

Ensembl ID: ENSMUSG00000031132

Description: CD40 ligand

Associated with

Adaptive immune system
(R-MMU-1280218)
Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Immunoregulatory interactions between a lymphoid and a non-lymphoid cell
(R-MMU-198933)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
(R-MMU-5676594)
B cell differentiation
(GO:0030183)
B cell proliferation
(GO:0042100)
Cd40 receptor binding
(GO:0005174)
Cd40 signaling pathway
(GO:0023035)
Cell body
(GO:0044297)
Cell projection
(GO:0042995)
Cell surface
(GO:0009986)
Cytokine activity
(GO:0005125)
Dendritic cell differentiation
(GO:0097028)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Immune response
(GO:0006955)
Immunoglobulin production
(GO:0002377)
Inflammatory response
(GO:0006954)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Isotype switching
(GO:0045190)
Membrane
(GO:0016020)
Negative regulation of apoptotic process
(GO:0043066)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of dendritic cell differentiation
(GO:2001200)
Positive regulation of endothelial cell apoptotic process
(GO:2000353)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of immune response to tumor cell
(GO:0002839)
Positive regulation of interleukin-4 production
(GO:0032753)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of mhc class ii biosynthetic process
(GO:0045348)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of type ii interferon production
(GO:0032729)
Protein serine/threonine kinase activator activity
(GO:0043539)
Regulation of immunoglobulin production
(GO:0002637)
Signal transduction
(GO:0007165)
Tumor necrosis factor receptor binding
(GO:0005164)

Other Information

Proteins

CD40 ligand

Genular Protein ID: 4294965795

Symbol: CD40L_MOUSE

Name: CD40 ligand

UniProtKB Accession Codes:

P27548

Database IDs:

Citations:

PubMed ID: 1374165

Title: Molecular and biological characterization of a murine ligand for CD40.

PubMed ID: 1374165

DOI: 10.1038/357080a0

PubMed ID: 7520529

Title: Structure of the murine CD40 ligand gene.

PubMed ID: 7520529

DOI: 10.1016/0161-5890(94)90009-4

PubMed ID: 1377364

Title: Emerging cytokine family.

PubMed ID: 1377364

DOI: 10.1038/358026b0

PubMed ID: 8095800

Title: A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors.

PubMed ID: 8095800

DOI: 10.1093/intimm/5.2.233

Sequence Information:

Length: 260
Mass: 29370
Checksum: 7E1AC117473672AD
Sequence:

MIETYSQPSP RSVATGLPAS MKIFMYLLTV FLITQMIGSV LFAVYLHRRL DKVEEEVNLH 
EDFVFIKKLK RCNKGEGSLS LLNCEEMRRQ FEDLVKDITL NKEEKKENSF EMQRGDEDPQ 
IAAHVVSEAN SNAASVLQWA KKGYYTMKSN LVMLENGKQL TVKREGLYYV YTQVTFCSNR 
EPSSQRPFIV GLWLKPSSGS ERILLKAANT HSSSQLCEQQ SVHLGGVFEL QAGASVFVNV 
TEASQVIHRV GFSSFGLLKL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cd40lg

Associated with

Other Information

Molecular and biological characterization of a murine ligand for CD40. PubMed ID: 1374165

Structure of the murine CD40 ligand gene. PubMed ID: 7520529

Emerging cytokine family. PubMed ID: 1377364

A 3-D model for the CD40 ligand predicts that it is a compact trimer similar to the tumor necrosis factors. PubMed ID: 8095800

Database document:

PubMed ID: 1374165

PubMed ID: 7520529

PubMed ID: 1377364

PubMed ID: 8095800