Genular: Defining Cellular Identity and Function

Details for: Tnr

Gene ID: 21960

Symbol: Tnr

Ensembl ID: ENSMUSG00000015829

Description: tenascin R

Associated with

Ecm proteoglycans
(R-MMU-3000178)
Associative learning
(GO:0008306)
Axon extension
(GO:0048675)
Axon extension involved in regeneration
(GO:0048677)
Cell adhesion
(GO:0007155)
Cell surface
(GO:0009986)
Collagen-containing extracellular matrix
(GO:0062023)
Extracellular matrix
(GO:0031012)
Extracellular matrix of synaptic cleft
(GO:0098965)
Extracellular matrix organization
(GO:0030198)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glutamatergic synapse
(GO:0098978)
Hippocampal mossy fiber to ca3 synapse
(GO:0098686)
Integrin binding
(GO:0005178)
Locomotory exploration behavior
(GO:0035641)
Long-term synaptic potentiation
(GO:0060291)
Membrane raft
(GO:0045121)
Modulation of chemical synaptic transmission
(GO:0050804)
Negative regulation of axon extension
(GO:0030517)
Negative regulation of axon extension involved in regeneration
(GO:0048692)
Negative regulation of cell-cell adhesion
(GO:0022408)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of synaptic transmission
(GO:0050805)
Neuroblast migration
(GO:0097402)
Neuromuscular process controlling balance
(GO:0050885)
Neuron cell-cell adhesion
(GO:0007158)
Perineuronal net
(GO:0072534)
Perisynaptic extracellular matrix
(GO:0098966)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Positive regulation of transmission of nerve impulse
(GO:0051971)
Regulation of cell adhesion
(GO:0030155)
Regulation of cell differentiation
(GO:0045595)
Regulation of cell migration
(GO:0030334)
Schaffer collateral - ca1 synapse
(GO:0098685)
Sphingolipid binding
(GO:0046625)
Synapse organization
(GO:0050808)
Synaptic transmission, glutamatergic
(GO:0035249)
Telencephalon cell migration
(GO:0022029)
Tenascin complex
(GO:0090733)

Other Information

Proteins

Tenascin-R

Genular Protein ID: 3287214491

Symbol: TENR_MOUSE

Name: Tenascin-R

UniProtKB Accession Codes:

Q8BYI9 A2RT70 O88717

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10341229

Title: Mice deficient for tenascin-r display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS.

PubMed ID: 10341229

DOI: 10.1523/jneurosci.19-11-04245.1999

PubMed ID: 2477380

Title: J1-160 and J1-180 are oligodendrocyte-secreted nonpermissive substrates for cell adhesion.

PubMed ID: 2477380

DOI: 10.1083/jcb.109.4.1765

PubMed ID: 7678967

Title: The F3/11 cell adhesion molecule mediates the repulsion of neurons by the extracellular matrix glycoprotein J1-160/180.

PubMed ID: 7678967

DOI: 10.1016/0896-6273(93)90243-k

PubMed ID: 9169525

Title: Tenascin-R is an intrinsic autocrine factor for oligodendrocyte differentiation and promotes cell adhesion by a sulfatide-mediated mechanism.

PubMed ID: 9169525

DOI: 10.1523/jneurosci.17-12-04642.1997

PubMed ID: 10383637

Title: Tenascin-R interferes with integrin-dependent oligodendrocyte precursor cell adhesion by a ganglioside-mediated signalling mechanism.

PubMed ID: 10383637

DOI: 10.1046/j.1460-9568.1999.00670.x

PubMed ID: 10406848

Title: Glycosylation of a CNS-specific extracellular matrix glycoprotein, tenascin-R, is dominated by O-linked sialylated glycans and 'brain-type' neutral N-glycans.

PubMed ID: 10406848

DOI: 10.1093/glycob/9.8.823

PubMed ID: 10773191

Title: Involvement of chondroitin sulfates on brain-derived tenascin-R in carbohydrate-dependent interactions with fibronectin and tenascin-C.

PubMed ID: 10773191

DOI: 10.1016/s0006-8993(00)02075-8

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 1358
Mass: 149589
Checksum: 354D2E71AB356952
Sequence:

MGIDGETVVL KNMLIGVNLI LLGSMLKPSE CRLEVTTERA QRQTVEEEGG ASSYNTSSKE 
QPMVFNHVYN INVPLESLCS SGLEASAEQD MSAEDDTLAE YIGQTSDHES QVTFTHKINL 
PKKACPCASS SQVLQELLSR IEMLEREVSL LRDQCNTNCC QESAATGQLD YVPHCSGHGN 
FSFESCGCIC NEGWFGKNCS EPYCPLGCSS RGVCVDGQCI CDSEYSGDDC SELRCPTDCS 
SRGLCVDGEC VCEEPYTGED CRELRCPGDC SGKGQCANGT CLCQEGYAGE DCSQRRCLNA 
CSGRGHCQEG LCICEEGYQG PDCSAVAPPE DLRVAGISDR SIELEWDGPM AVTEYVISYQ 
PTALGGLQLQ QRVPGDWSGV TIMELEPGLT YNISVYAVIS NILSLPITAK VATHLSTPQG 
LQFKTITETT VEVQWEPFSF SFDGWEISFI PKNNEGGVIA QLPSDVTSFN QTGLKPGEEY 
IVNVVALKEQ ARSPPTSASV STVIDGPTQI LVRDVSDTVA FVEWTPPRAK VDFILLKYGL 
VGGEGGKTTF RLQPPLSQYS VQALRPGSRY EVSISAVRGT NESEASSTQF TTEIDAPKNL 
RVGSRTATSL DLEWDNSEAE AQEYKVVYST LAGEQYHEVL VPKGIGPTTK TTLTDLVPGT 
EYGVGISAVM NSKQSIPATM NARTELDSPR DLMVTASSET SISLIWTKAS GPIDHYRITF 
TPSSGISSEV TVPRDRTSYT LTDLEPGAEY IISITAERGR QQSLESTVDA FTGFRPISHL 
HFSHVTSSSV NITWSDPSPP ADRLILNYSP RDKEEDMLEV LLDATKRHAV LMGLQPATEY 
IVNLVAVHGT VTSEPIVGSI TTGIDPPKNI TISNVTKDSL TVSWSSPVAP FDYYRVSYRP 
TQVGRLDSSV VPNTVTEFAI TRLYPATEYE ISLNSVRGRE ESERICTLVH TAMDSPMDLI 
ATNITPTEAL LQWKAPMGEV ENYVIVLTHF AIAGETILVD GVSEEFQLVD LLPSTHYTVT 
MYATSGPLMS GTIATNFSTL LDPPDNLTAS EVTRQSALIS WQPPRAAIEN YVLTYKSTDG 
SRKELIVDAE DTWIRLEGLS ENTDYTVLLQ AAQEATRSSL TSTVFTTGGR VFSHPQDCAQ 
HLMNGDTLSG VYTIFLNGEL SHKLQVYCDM TTDGGGWIVF QRRQNGQTDF FRKWADYRVG 
FGNLEDEFWL GLDNIHRITA QGRYELRVDM RDGQEAVFAY YDKFAVEDSR SLYKIRIGSY 
NGTAGDSLSY HQGRPFSTED RDNDVAVTNC AMSYKGAWWY KNCHRTNLNG KYGESRHSQG 
INWYHWKGHE FSIPFVEMKM RPYIHRLTAG RKRRALKF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tnr

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mice deficient for tenascin-r display alterations of the extracellular matrix and decreased axonal conduction velocities in the CNS. PubMed ID: 10341229

J1-160 and J1-180 are oligodendrocyte-secreted nonpermissive substrates for cell adhesion. PubMed ID: 2477380

The F3/11 cell adhesion molecule mediates the repulsion of neurons by the extracellular matrix glycoprotein J1-160/180. PubMed ID: 7678967

Tenascin-R is an intrinsic autocrine factor for oligodendrocyte differentiation and promotes cell adhesion by a sulfatide-mediated mechanism. PubMed ID: 9169525

Tenascin-R interferes with integrin-dependent oligodendrocyte precursor cell adhesion by a ganglioside-mediated signalling mechanism. PubMed ID: 10383637

Glycosylation of a CNS-specific extracellular matrix glycoprotein, tenascin-R, is dominated by O-linked sialylated glycans and 'brain-type' neutral N-glycans. PubMed ID: 10406848

Involvement of chondroitin sulfates on brain-derived tenascin-R in carbohydrate-dependent interactions with fibronectin and tenascin-C. PubMed ID: 10773191

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079