Genular: Defining Cellular Identity and Function

Details for: Top2a

Gene ID: 21973

Symbol: Top2a

Ensembl ID: ENSMUSG00000020914

Description: topoisomerase (DNA) II alpha

Associated with

Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of dna replication proteins
(R-MMU-4615885)
Apoptotic chromosome condensation
(GO:0030263)
Atp-dependent activity, acting on dna
(GO:0008094)
Atp binding
(GO:0005524)
Centriole
(GO:0005814)
Chromatin binding
(GO:0003682)
Chromosome, centromeric region
(GO:0000775)
Chromosome condensation
(GO:0030261)
Chromosome segregation
(GO:0007059)
Condensed chromosome
(GO:0000793)
Cytoplasm
(GO:0005737)
Dna binding
(GO:0003677)
Dna binding, bending
(GO:0008301)
Dna damage response
(GO:0006974)
Dna ligation
(GO:0006266)
Dna metabolic process
(GO:0006259)
Dna topoisomerase activity
(GO:0003916)
Dna topoisomerase type ii (double strand cut, atp-hydrolyzing) activity
(GO:0003918)
Dna topoisomerase type ii (double strand cut, atp-hydrolyzing) complex
(GO:0009330)
Dna topological change
(GO:0006265)
Embryonic cleavage
(GO:0040016)
Female meiosis chromosome separation
(GO:0051309)
Female meiotic nuclear division
(GO:0007143)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Isomerase activity
(GO:0016853)
Magnesium ion binding
(GO:0000287)
Male germ cell nucleus
(GO:0001673)
Metal ion binding
(GO:0046872)
Negative regulation of dna duplex unwinding
(GO:1905463)
Nuclear chromosome
(GO:0000228)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of single stranded viral rna replication via double stranded dna intermediate
(GO:0045870)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein kinase c binding
(GO:0005080)
Regulation of circadian rhythm
(GO:0042752)
Resolution of meiotic recombination intermediates
(GO:0000712)
Rhythmic process
(GO:0048511)
Ribonucleoprotein complex
(GO:1990904)
Sequence-specific dna binding
(GO:0043565)
Sister chromatid segregation
(GO:0000819)
Ubiquitin binding
(GO:0043130)

Other Information

Proteins

DNA topoisomerase 2-alpha

Genular Protein ID: 1947242514

Symbol: TOP2A_MOUSE

Name: DNA topoisomerase 2-alpha

UniProtKB Accession Codes:

Q01320 E9PX08

Database IDs:

Citations:

PubMed ID: 1331984

Title: Characterization of cDNA encoding the mouse DNA topoisomerase II that can complement the budding yeast top2 mutation.

PubMed ID: 1331984

DOI: 10.1093/nar/20.20.5297

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 8261398

Title: Characterization of a DNA topoisomerase IIalpha gene rearrangement in adriamycin-resistant P388 leukemia: expression of a fusion messenger RNA transcript encoding topoisomerase IIalpha and the retinoic acid receptor alpha locus.

PubMed ID: 8261398

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 24321095

Title: Shikonin shortens the circadian period: possible involvement of Top2 inhibition.

PubMed ID: 24321095

DOI: 10.1016/j.bbrc.2013.11.116

PubMed ID: 31839538

Title: GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability.

PubMed ID: 31839538

DOI: 10.1016/j.devcel.2019.11.006

Sequence Information:

Length: 1528
Mass: 172790
Checksum: 63CBF8F649D103C7
Sequence:

MELSPLQPVN ENMLMNKKKN EDGKKRLSIE RIYQKKTQLE HILLRPDTYI GSVELVTQQM 
WVYDEDVGIN YREVTFVPGL YKIFDEILVN AADNKQRDPK MSCIRVTIDP ENNVISIWNN 
GKGIPVVEHK VEKIYVPALI FGQLLTSSNY DDDEKKVTGG RNGYGAKLCN IFSTKFTVET 
ASREYKKMFK QTWMDNMGRA GDMELKPFSG EDYTCITFQP DLSKFKMQSL DKDIVALMVR 
RAYDIAGSTK DVKVFLNGNS LPVKGFRSYV DLYLKDKVDE TGNSLKVIHE QVNPRWEVCL 
TMSERGFQQI SFVNSIATSK GGRHVDYVAD QIVSKLVDVV KKKNKGGVAV KAHQVKNHMW 
IFVNALIENP TFDSQTKENM TLQAKSFGST CQLSEKFIKA AIGCGIVESI LNWVKFKAQI 
QLNKKCSAVK HTKIKGIPKL DDANDAGSRN STECTLILTE GDSAKTLAVS GLGVVGRDKY 
GVFPLRGKIL NVREASHKQI MENAEINNII KIVGLQYKKN YEDEDSLKTL RYGKIMIMTD 
QDQDGSHIKG LLINFIHHNW PSLLRHRFLE EFITPIVKVS KNKQEIAFYS LPEFEEWKSS 
TPNHKKWKVK YYKGLGTSTS KEAKEYFADM KRHRIQFKYS GPEDDAAISL AFSKKQVDDR 
KEWLTNFMED RRQRKLLGLP EDYLYGQSTS YLTYNDFINK ELILFSNSDN ERSIPSMVDG 
LKPGQRKVLF TCFKRNDKRE VKVAQLAGSV AEMSSYHHGE MSLMMTIINL AQNFVGSNNL 
NLLQPIGQFG TRLHGGKDSA SPRYIFTMLS PLARLLFPPK DDHTLRFLYD DNQRVEPEWY 
IPIIPMVLIN GAEGIGTGWS CKIPNFDVRE VVNNIRRLLD GEEPLPMLPS YKNFKGTIEE 
LASNQYVING EVAILDSTTI EISELPIRTW TQTYKEQVLE PMLNGTEKTP SLITDYREYH 
TDTTVKFVIK MTEEKLAEAE RVGLHKVFKL QSSLTCNSMV LFDHVGCLKK YDTVLDILRD 
FFELRLKYYG LRKEWLLGML GAESSKLNNQ ARFILEKIDG KIVIENKPKK ELIKVLIQRG 
YDSDPVKAWK EAQQKVPDEE ENEESDTETS TSDSAAEAGP TFNYLLDMPL WYLTKEKKDE 
LCKQRNEKEQ ELNTLKQKSP SDLWKEDLAV FIEELEVVEA KEKQDEQVGL PGKAGKAKGK 
KAQMCADVLP SPRGKRVIPQ VTVEMKAEAE KKIRKKIKSE NVEGTPAEDG AEPGSLRQRI 
EKKQKKEPGA KKQTTLPFKP VKKGRKKNPW SDSESDVSSN ESNVDVPPRQ KEQRSAAAKA 
KFTVDLDSDE DFSGLDEKDE DEDFLPLDAT PPKAKIPPKN TKKALKTQGS SMSVVDLESD 
VKDSVPASPG VPAADFPAET EQSKPSKKTV GVKKTATKSQ SSVSTAGTKK RAAPKGTKSD 
SALSARVSEK PAPAKAKNSR KRKPSSSDSS DSDFERAISK GATSKKAKGE EQDFPVDLED 
TIAPRAKSDR ARKPIKYLEE SDDDDDLF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Top2a

Associated with

Other Information

Characterization of cDNA encoding the mouse DNA topoisomerase II that can complement the budding yeast top2 mutation. PubMed ID: 1331984

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Characterization of a DNA topoisomerase IIalpha gene rearrangement in adriamycin-resistant P388 leukemia: expression of a fusion messenger RNA transcript encoding topoisomerase IIalpha and the retinoic acid receptor alpha locus. PubMed ID: 8261398

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Shikonin shortens the circadian period: possible involvement of Top2 inhibition. PubMed ID: 24321095

GCNA Interacts with Spartan and Topoisomerase II to Regulate Genome Stability. PubMed ID: 31839538