ABCB7 - ENSG00000131269

Details for: ABCB7

Gene ID: 22

Symbol: ABCB7

Ensembl ID: ENSG00000131269

Description: ATP binding cassette subfamily B member 7

Associated with

Abc-family proteins mediated transport (R-HSA-382556)
Cytosolic iron-sulfur cluster assembly (R-HSA-2564830)
Metabolism (R-HSA-1430728)
Mitochondrial abc transporters (R-HSA-1369007)
Transport of small molecules (R-HSA-382551)
Abc-type iron-sulfur cluster transporter activity (GO:0140481)
Atpase-coupled transmembrane transporter activity (GO:0042626)
Atp binding (GO:0005524)
Atp hydrolysis activity (GO:0016887)
Heme transmembrane transporter activity (GO:0015232)
Heme transport (GO:0015886)
Identical protein binding (GO:0042802)
Intracellular iron ion homeostasis (GO:0006879)
Iron-sulfur cluster assembly (GO:0016226)
Iron-sulfur cluster export from the mitochondrion (GO:0140466)
Iron ion transmembrane transport (GO:0034755)
Mitochondrial inner membrane (GO:0005743)
Mitochondrion (GO:0005739)
Negative regulation of reactive oxygen species biosynthetic process (GO:1903427)
Positive regulation of heme biosynthetic process (GO:0070455)
Positive regulation of iron-sulfur cluster assembly (GO:1903331)
Protein binding (GO:0005515)
Protein homodimerization activity (GO:0042803)
Transmembrane transport (GO:0055085)

Cells (max top 100)

Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.92
Marker Score: 42809
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.89
Marker Score: 2536
Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 1.58
Marker Score: 5602
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.54
Marker Score: 1234
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 1.53
Marker Score: 1852
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.4
Marker Score: 1551
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.35
Marker Score: 791
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.32
Marker Score: 2906
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.28
Marker Score: 78695.5
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.28
Marker Score: 27244.5
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.27
Marker Score: 10935.5
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.26
Marker Score: 1944
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.2
Marker Score: 11395.5
Cell Name: oogonial cell (CL0000024)
Fold Change: 1.18
Marker Score: 1703
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.18
Marker Score: 11131.5
Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.17
Marker Score: 1457
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.16
Marker Score: 4827
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.16
Marker Score: 42810
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 1.1
Marker Score: 41957
Cell Name: neuron (CL0000540)
Fold Change: 1.1
Marker Score: 4483
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.07
Marker Score: 11052.5
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.06
Marker Score: 15869
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 1.06
Marker Score: 618
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.05
Marker Score: 1205
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.04
Marker Score: 516
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.04
Marker Score: 4336.5
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.03
Marker Score: 20433
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1
Marker Score: 418
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71691
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47916
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.99
Marker Score: 7625.5
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.99
Marker Score: 759
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.98
Marker Score: 667
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30391
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.98
Marker Score: 984
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.96
Marker Score: 3697
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.95
Marker Score: 500
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2397
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.94
Marker Score: 2361
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.93
Marker Score: 1171.5
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 481
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.93
Marker Score: 437
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.92
Marker Score: 321
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 0.91
Marker Score: 2486
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.91
Marker Score: 266
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2700
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.9
Marker Score: 445
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.89
Marker Score: 955
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5293
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.87
Marker Score: 421
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 308
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.86
Marker Score: 759
Cell Name: fat cell (CL0000136)
Fold Change: 0.85
Marker Score: 473.5
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.84
Marker Score: 4807
Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 0.84
Marker Score: 267
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.84
Marker Score: 1366
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.84
Marker Score: 13141.5
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 0.83
Marker Score: 1173
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.82
Marker Score: 1450
Cell Name: B-1 B cell (CL0000819)
Fold Change: 0.82
Marker Score: 1426
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.81
Marker Score: 482
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.8
Marker Score: 321
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.8
Marker Score: 1539
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.8
Marker Score: 1129.5
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 0.8
Marker Score: 958
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.8
Marker Score: 901
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.79
Marker Score: 837
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 0.79
Marker Score: 276
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.78
Marker Score: 413
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.78
Marker Score: 7893.5
Cell Name: hepatocyte (CL0000182)
Fold Change: 0.78
Marker Score: 531
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.78
Marker Score: 593
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.77
Marker Score: 4980
Cell Name: oocyte (CL0000023)
Fold Change: 0.77
Marker Score: 190
Cell Name: late pro-B cell (CL0002048)
Fold Change: 0.77
Marker Score: 903
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.76
Marker Score: 240
Cell Name: primitive red blood cell (CL0002355)
Fold Change: 0.76
Marker Score: 568
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.75
Marker Score: 524
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.75
Marker Score: 242
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.75
Marker Score: 191
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.75
Marker Score: 688
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.75
Marker Score: 474
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.74
Marker Score: 203
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.74
Marker Score: 2011
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.73
Marker Score: 265.5
Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.73
Marker Score: 274
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.73
Marker Score: 3156.5
Cell Name: male germ cell (CL0000015)
Fold Change: 0.73
Marker Score: 210
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.73
Marker Score: 767
Cell Name: neural cell (CL0002319)
Fold Change: 0.73
Marker Score: 351
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 375
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.72
Marker Score: 692
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.72
Marker Score: 3006
Cell Name: melanocyte (CL0000148)
Fold Change: 0.71
Marker Score: 289
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.71
Marker Score: 882
Cell Name: basal cell (CL0000646)
Fold Change: 0.71
Marker Score: 918
Cell Name: podocyte (CL0000653)
Fold Change: 0.71
Marker Score: 262
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.71
Marker Score: 512.5
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.7
Marker Score: 239
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.7
Marker Score: 243

**Key characteristics:** - ABCB7 is a type of ATP-binding cassette protein, which are a family of proteins that are involved in the transport of molecules between the cytosol and the extracellular environment. - ABCB7 is expressed in a variety of cell types, including cardiac myocytes, lens epithelial cells, and immune cells. - ABCB7 is a key regulator of heme biosynthetic process, as it is involved in the transport of iron ions between the cytosol and the mitochondria. - ABCB7 is also involved in the transport of small molecules between the cytosol and the extracellular environment. **Pathways and functions:** - ABCB7 is involved in the Abc-family proteins mediated transport pathway, which is responsible for the transport of molecules between the cytosol and the extracellular environment. - ABCB7 is also involved in the Abc-type iron-sulfur cluster transporter activity, which is responsible for the transport of iron ions between the cytosol and the mitochondria. - ABCB7 is also involved in the ATP-coupled transmembrane transporter activity, which is responsible for the transport of molecules between the cytosol and the extracellular environment. **Clinical significance:** - ABCB7 gene mutations have been linked to a number of human diseases, including sickle cell disease, beta-thalassemia, and hereditary spherocytosis. - Targeting ABCB7 has been shown to be a potential therapeutic strategy for these diseases.

Database document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.