Details for: ABCB7

Gene ID: 22

Symbol: ABCB7

Ensembl ID: ENSG00000131269

Description: ATP binding cassette subfamily B member 7

Associated with

Cells (max top 100)

  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.92
    Marker Score: 42809
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.89
    Marker Score: 2536
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.58
    Marker Score: 5602
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.54
    Marker Score: 1234
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.53
    Marker Score: 1852
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.4
    Marker Score: 1551
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.35
    Marker Score: 791
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.32
    Marker Score: 2906
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.28
    Marker Score: 78695.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.28
    Marker Score: 27244.5
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.27
    Marker Score: 10935.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.26
    Marker Score: 1944
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.2
    Marker Score: 11395.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.18
    Marker Score: 1703
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.18
    Marker Score: 11131.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.17
    Marker Score: 1457
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.16
    Marker Score: 4827
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.16
    Marker Score: 42810
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.1
    Marker Score: 41957
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.1
    Marker Score: 4483
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.07
    Marker Score: 11052.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.06
    Marker Score: 15869
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.06
    Marker Score: 618
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.05
    Marker Score: 1205
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.04
    Marker Score: 516
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.04
    Marker Score: 4336.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.03
    Marker Score: 20433
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1
    Marker Score: 418
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71691
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47916
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.99
    Marker Score: 7625.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.99
    Marker Score: 759
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.98
    Marker Score: 667
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30391
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.98
    Marker Score: 984
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.96
    Marker Score: 3697
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.95
    Marker Score: 500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2397
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.94
    Marker Score: 2361
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.93
    Marker Score: 1171.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 481
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.92
    Marker Score: 321
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.91
    Marker Score: 2486
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.91
    Marker Score: 266
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2700
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.9
    Marker Score: 445
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.89
    Marker Score: 955
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.87
    Marker Score: 421
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.86
    Marker Score: 759
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.85
    Marker Score: 473.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4807
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.84
    Marker Score: 267
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1366
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13141.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.83
    Marker Score: 1173
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.82
    Marker Score: 1450
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.82
    Marker Score: 1426
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.81
    Marker Score: 482
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 321
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.8
    Marker Score: 1539
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.8
    Marker Score: 1129.5
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.8
    Marker Score: 958
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8
    Marker Score: 901
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.79
    Marker Score: 837
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.79
    Marker Score: 276
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.78
    Marker Score: 413
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.78
    Marker Score: 7893.5
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.78
    Marker Score: 531
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 593
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.77
    Marker Score: 4980
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.77
    Marker Score: 190
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.77
    Marker Score: 903
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.76
    Marker Score: 240
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.76
    Marker Score: 568
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.75
    Marker Score: 524
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.75
    Marker Score: 242
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.75
    Marker Score: 191
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.75
    Marker Score: 688
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.75
    Marker Score: 474
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.74
    Marker Score: 203
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.74
    Marker Score: 2011
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.73
    Marker Score: 265.5
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.73
    Marker Score: 274
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.73
    Marker Score: 3156.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.73
    Marker Score: 210
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.73
    Marker Score: 767
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.73
    Marker Score: 351
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.72
    Marker Score: 692
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3006
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.71
    Marker Score: 289
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.71
    Marker Score: 882
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.71
    Marker Score: 918
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.71
    Marker Score: 262
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.71
    Marker Score: 512.5
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.7
    Marker Score: 239
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.7
    Marker Score: 243
**Key characteristics:** - ABCB7 is a type of ATP-binding cassette protein, which are a family of proteins that are involved in the transport of molecules between the cytosol and the extracellular environment. - ABCB7 is expressed in a variety of cell types, including cardiac myocytes, lens epithelial cells, and immune cells. - ABCB7 is a key regulator of heme biosynthetic process, as it is involved in the transport of iron ions between the cytosol and the mitochondria. - ABCB7 is also involved in the transport of small molecules between the cytosol and the extracellular environment. **Pathways and functions:** - ABCB7 is involved in the Abc-family proteins mediated transport pathway, which is responsible for the transport of molecules between the cytosol and the extracellular environment. - ABCB7 is also involved in the Abc-type iron-sulfur cluster transporter activity, which is responsible for the transport of iron ions between the cytosol and the mitochondria. - ABCB7 is also involved in the ATP-coupled transmembrane transporter activity, which is responsible for the transport of molecules between the cytosol and the extracellular environment. **Clinical significance:** - ABCB7 gene mutations have been linked to a number of human diseases, including sickle cell disease, beta-thalassemia, and hereditary spherocytosis. - Targeting ABCB7 has been shown to be a potential therapeutic strategy for these diseases.

Database document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.