Details for: ABCB7

Gene ID: 22

Symbol: ABCB7

Ensembl ID: ENSG00000131269

Description: ATP binding cassette subfamily B member 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 171.7185
    Cell Significance Index: -26.7100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 104.0043
    Cell Significance Index: -26.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 67.0906
    Cell Significance Index: -31.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 65.8204
    Cell Significance Index: -26.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 59.1969
    Cell Significance Index: -30.4500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.1018
    Cell Significance Index: -26.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.4453
    Cell Significance Index: -30.1400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.0383
    Cell Significance Index: -29.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.6571
    Cell Significance Index: -26.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.1742
    Cell Significance Index: -17.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.9624
    Cell Significance Index: -31.4200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3384
    Cell Significance Index: 102.7100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2444
    Cell Significance Index: 1123.5800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.0905
    Cell Significance Index: 28.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0683
    Cell Significance Index: 116.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.9924
    Cell Significance Index: 55.6900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9554
    Cell Significance Index: 191.6500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9374
    Cell Significance Index: 186.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.7513
    Cell Significance Index: 10.2500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5918
    Cell Significance Index: 16.5400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4831
    Cell Significance Index: 173.2700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4583
    Cell Significance Index: 13.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4062
    Cell Significance Index: 24.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3949
    Cell Significance Index: 25.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3868
    Cell Significance Index: 17.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3845
    Cell Significance Index: 7.5100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3724
    Cell Significance Index: 14.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3716
    Cell Significance Index: 256.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2991
    Cell Significance Index: 6.4800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2910
    Cell Significance Index: 7.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2855
    Cell Significance Index: 51.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2752
    Cell Significance Index: 32.4600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2669
    Cell Significance Index: 18.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2469
    Cell Significance Index: 11.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2377
    Cell Significance Index: 129.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2169
    Cell Significance Index: 95.9000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2078
    Cell Significance Index: 25.5600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1833
    Cell Significance Index: 25.1700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1787
    Cell Significance Index: 34.0100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.1592
    Cell Significance Index: 2.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1582
    Cell Significance Index: 291.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1281
    Cell Significance Index: 197.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1121
    Cell Significance Index: 5.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1003
    Cell Significance Index: 9.9200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0927
    Cell Significance Index: 174.4700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0821
    Cell Significance Index: 5.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0686
    Cell Significance Index: 31.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0659
    Cell Significance Index: 1.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0653
    Cell Significance Index: 41.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0592
    Cell Significance Index: 80.4500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0479
    Cell Significance Index: 6.1900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0465
    Cell Significance Index: 0.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0205
    Cell Significance Index: 1.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0168
    Cell Significance Index: 2.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0078
    Cell Significance Index: 0.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0067
    Cell Significance Index: 0.1600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0052
    Cell Significance Index: -0.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0095
    Cell Significance Index: -1.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0144
    Cell Significance Index: -0.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0151
    Cell Significance Index: -0.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0166
    Cell Significance Index: -0.4500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0219
    Cell Significance Index: -16.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0305
    Cell Significance Index: -23.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0326
    Cell Significance Index: -24.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0372
    Cell Significance Index: -6.3600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0514
    Cell Significance Index: -29.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0522
    Cell Significance Index: -5.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0549
    Cell Significance Index: -34.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0587
    Cell Significance Index: -4.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0689
    Cell Significance Index: -4.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0970
    Cell Significance Index: -27.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1041
    Cell Significance Index: -12.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1557
    Cell Significance Index: -32.8000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1570
    Cell Significance Index: -1.2800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1813
    Cell Significance Index: -3.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1883
    Cell Significance Index: -5.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1939
    Cell Significance Index: -22.2100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2048
    Cell Significance Index: -2.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2209
    Cell Significance Index: -23.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2657
    Cell Significance Index: -8.5100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3045
    Cell Significance Index: -7.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3057
    Cell Significance Index: -16.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.3099
    Cell Significance Index: -8.1500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3152
    Cell Significance Index: -3.9100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3350
    Cell Significance Index: -4.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3412
    Cell Significance Index: -7.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3537
    Cell Significance Index: -28.0100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3658
    Cell Significance Index: -7.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4261
    Cell Significance Index: -26.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4607
    Cell Significance Index: -13.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4758
    Cell Significance Index: -16.5400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4837
    Cell Significance Index: -12.0900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4859
    Cell Significance Index: -8.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4957
    Cell Significance Index: -10.5200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.5445
    Cell Significance Index: -3.2900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5482
    Cell Significance Index: -17.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5640
    Cell Significance Index: -18.4700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5683
    Cell Significance Index: -13.1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5849
    Cell Significance Index: -15.6500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ABCB7 is a transmembrane transporter protein that belongs to the ABCB subfamily of the ATP-binding cassette transporter superfamily. Its primary function is to transport iron-sulfur clusters across cellular membranes, ensuring the proper assembly and regulation of these essential complexes. Additionally, ABCB7 has been implicated in the transport of heme, a critical cofactor for various cellular processes, including oxygen transport and DNA synthesis. The protein's ability to bind identical proteins and participate in homodimerization further underscores its importance in maintaining cellular homeostasis. **Pathways and Functions:** ABCB7 is involved in several key pathways, including: 1. **Iron-Sulfur Cluster Assembly:** ABCB7 plays a crucial role in the assembly and regulation of iron-sulfur clusters, which are essential for various cellular processes, including energy production, DNA synthesis, and antioxidant defenses. 2. **Heme Transport:** ABCB7 has been implicated in the transport of heme, a critical cofactor for various cellular processes, including oxygen transport and DNA synthesis. 3. **Cytosolic Iron Ion Homeostasis:** ABCB7 helps maintain cytosolic iron ion homeostasis by regulating iron-sulfur cluster assembly and heme transport. 4. **Mitochondrial Iron-Sulfur Cluster Export:** ABCB7 is also involved in the export of iron-sulfur clusters from the mitochondria, ensuring the proper regulation of mitochondrial iron-sulfur cluster homeostasis. 5. **Negative Regulation of Reactive Oxygen Species Biosynthesis:** ABCB7 has been shown to negatively regulate the biosynthesis of reactive oxygen species (ROS), which are essential for cellular signaling and homeostasis. **Clinical Significance:** The dysregulation of ABCB7 has significant implications for various diseases, including: 1. **Mitochondrial Diseases:** Mutations in ABCB7 have been linked to mitochondrial diseases, such as mitochondrial myopathies and neurodegenerative disorders. 2. **Iron-Related Disorders:** Dysregulation of ABCB7 has been implicated in iron-related disorders, including hemochromatosis and iron overload. 3. **Cancer:** ABCB7 has been shown to play a role in cancer development and progression, particularly in the context of iron-sulfur cluster homeostasis and heme transport. 4. **Neurodegenerative Disorders:** ABCB7 has been implicated in the development and progression of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, ABCB7 is a critical player in iron-sulfur cluster homeostasis and heme transport, with significant implications for various cellular processes and diseases. Further research is necessary to fully elucidate the mechanisms by which ABCB7 regulates iron-sulfur cluster assembly and heme transport, and to explore the therapeutic potential of targeting this gene in the context of various diseases.

Genular Protein ID: 3165009232

Symbol: ABCB7_HUMAN

Name: ATP-binding cassette transporter 7

UniProtKB Accession Codes:

O75027 G3XAC4 O75345 Q5VWY7 Q5VWY8 Q9BRE1 Q9UND1 Q9UP01

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CTD 1 ChEBI 11 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 25 EMDB 1 Ensembl 3 ExpressionAtlas 1 GO 17 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 3 Rhea 2 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9621516

Title: Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia.

PubMed ID: 9621516

DOI: 10.1007/s100380050051

PubMed ID: 10196363

Title: Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A).

PubMed ID: 10196363

DOI: 10.1093/hmg/8.5.743

PubMed ID: 11050011

Title: Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation.

PubMed ID: 11050011

PubMed ID: 9653160

Title: Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning.

PubMed ID: 9653160

DOI: 10.1073/pnas.95.14.8175

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9883897

Title: Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p.

PubMed ID: 9883897

DOI: 10.1016/s0014-5793(98)01560-9

PubMed ID: 17192393

Title: RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload.

PubMed ID: 17192393

DOI: 10.1182/blood-2006-08-041632

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25063848

Title: PAAT, a novel ATPase and trans-regulator of mitochondrial ABC transporters, is critically involved in the maintenance of mitochondrial homeostasis.

PubMed ID: 25063848

DOI: 10.1096/fj.14-254045

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30765471

Title: Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.

PubMed ID: 30765471

DOI: 10.3324/haematol.2018.214320

PubMed ID: 33157103

Title: Evolution of the human mitochondrial ABCB7 [2Fe-2S](GS)4 cluster exporter and the molecular mechanism of an E433K disease-causing mutation.

PubMed ID: 33157103

DOI: 10.1016/j.abb.2020.108661

PubMed ID: 11843825

Title: X-linked cerebellar ataxia and sideroblastic anaemia associated with a missense mutation in the ABC7 gene predicting V411L.

PubMed ID: 11843825

DOI: 10.1046/j.1365-2141.2001.03015.x

PubMed ID: 22398176

Title: X-linked sideroblastic anemia and ataxia: A new family with identification of a fourth ABCB7 gene mutation.

PubMed ID: 22398176

DOI: 10.1016/j.ejpn.2012.02.003

Sequence Information:

  • Length: 752
  • Mass: 82641
  • Checksum: B1FFA57ABD24FB90
  • Sequence:
    • MALLAMHSWR WAAAAAAFEK RRHSAILIRP LVSVSGSGPQ WRPHQLGALG TARAYQIPES 
LKSITWQRLG KGNSGQFLDA AKALQVWPLI EKRTCWHGHA GGGLHTDPKE GLKDVDTRKI 
IKAMLSYVWP KDRPDLRARV AISLGFLGGA KAMNIVVPFM FKYAVDSLNQ MSGNMLNLSD 
APNTVATMAT AVLIGYGVSR AGAAFFNEVR NAVFGKVAQN SIRRIAKNVF LHLHNLDLGF 
HLSRQTGALS KAIDRGTRGI SFVLSALVFN LLPIMFEVML VSGVLYYKCG AQFALVTLGT 
LGTYTAFTVA VTRWRTRFRI EMNKADNDAG NAAIDSLLNY ETVKYFNNER YEAQRYDGFL 
KTYETASLKS TSTLAMLNFG QSAIFSVGLT AIMVLASQGI VAGTLTVGDL VMVNGLLFQL 
SLPLNFLGTV YRETRQALID MNTLFTLLKV DTQIKDKVMA SPLQITPQTA TVAFDNVHFE 
YIEGQKVLSG ISFEVPAGKK VAIVGGSGSG KSTIVRLLFR FYEPQKGSIY LAGQNIQDVS 
LESLRRAVGV VPQDAVLFHN TIYYNLLYGN ISASPEEVYA VAKLAGLHDA ILRMPHGYDT 
QVGERGLKLS GGEKQRVAIA RAILKDPPVI LYDEATSSLD SITEETILGA MKDVVKHRTS 
IFIAHRLSTV VDADEIIVLD QGKVAERGTH HGLLANPHSI YSEMWHTQSS RVQNHDNPKW 
EAKKENISKE EERKKLQEEI VNSVKGCGNC SC

Genular Protein ID: 2345728475

Symbol: A0A087WW65_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087WW65

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 7 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 2 SAM 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 713
  • Mass: 78288
  • Checksum: D7D9854F432DDB96
  • Sequence:
    • MALLAMHSWR WAAAAAAFEK RRHSAILIRP LVSVSGSGPQ WRPHQLGALG TARAYQQIPE 
SLKSITWQRL GKGNSGQFLD AAKALQVWPL IEKRTCWHGH AGGGLHTDPK EGAMNIVVPF 
MFKYAVDSLN QMSGNMLNLS DAPNTVATMA TAVLIGYGVS RAGAAFFNEV RNAVFGKVAQ 
NSIRRIAKNV FLHLHNLDLG FHLSRQTGAL SKAIDRGTRG ISFVLSALVF NLLPIMFEVM 
LVSGVLYYKC GAQFALVTLG TLGTYTAFTV AVTRWRTRFR IEMNKADNDA GNAAIDSLLN 
YETVKYFNNE RYEAQRYDGF LKTYETASLK STSTLAMLNF GQSAIFSVGL TAIMVLASQG 
IVAGTLTVGD LVMVNGLLFQ LSLPLNFLGT VYRETRQALI DMNTLFTLLK VDTQIKDKVM 
ASPLQITPQT ATVAFDNVHF EYIEGQKVLS GISFEVPAGK KVAIVGGSGS GKSTIVRLLF 
RFYEPQKGSI YLAGQNIQDV SLESLRRAVG VVPQDAVLFH NTIYYNLLYG NISASPEEVY 
AVAKLAGLHD AILRMPHGYD TQVGERGLKL SGGEKQRVAI ARAILKDPPV ILYDEATSSL 
DSITEETILG AMKDVVKHRT SIFIAHRLST VVDADEIIVL DQGKVAERGT HHGLLANPHS 
IYSEMWHTQS SRVQNHDNPK WEAKKENISK EEERKKLQEE IVNSVKGCGN CSC

Genular Protein ID: 2192703443

Symbol: A0A0S2Z2Z3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z2Z3

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 5 Gene3D 2 IntAct 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 Pfam 2 RefSeq 1 Rhea 2 SAM 1 SMART 1 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 753
  • Mass: 82769
  • Checksum: 9B96042C55C3C62F
  • Sequence:
    • MALLAMHSWR WAAAAAAFEK RRHSAILIRP LVSVSGSGPQ WRPHQLGALG TARAYQQIPE 
SLKSITWQRL GKGNSGQFLD AAKALQVWPL IEKRTCWHGH AGGGLHTDPK EGLKDVDTRK 
IIKAMLSYVW PKDRPDLRAR VAISLGFLGG AKAMNIVVPF MFKYAVDSLN QMSGNMLNLS 
DAPNTVATMA TAVLIGYGVS RAGAAFFNEV RNAVFGKVAQ NSIRRIAKNV FLHLHNLDLG 
FHLSRQTGAL SKAIDRGTRG ISFVLSALVF NLLPIMFEVM LVSGVLYYKC GAQFALVTLG 
TLGTYTAFTV AVTRWRTRFR IEMNKADNDA GNAAIDSLLN YETVKYFNNE RYEAQRYDGF 
LKTYETASLK STSTLAMLNF GQSAIFSVGL TAIMVLASQG IVAGTLTVGD LVMVNGLLFQ 
LSLPLNFLGT VYRETRQALI DMNTLFTLLK VDTQIKDKVM ASPLQITPQT ATVAFDNVHF 
EYIEGQKVLS GISFEVPAGK KVAIVGGSGS GKSTIVRLLF RFYEPQKGSI YLAGQNIQDV 
SLESLRRAVG VVPQDAVLFH NTIYYNLLYG NISASPEEVY AVAKLAGLHD AILRMPHGYD 
TQVGERGLKL SGGEKQRVAI ARAILKDPPV ILYDEATSSL DSITEETILG AMKDVVKHRT 
SIFIAHRLST VVDADEIIVL DQGKVAERGT HHGLLANPHS IYSEMWHTQS SRVQNHDNPK 
WEAKKENISK EEERKKLQEE IVNSVKGCGN CSC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.