Details for: ALDH1A3

Gene ID: 220

Symbol: ALDH1A3

Ensembl ID: ENSG00000184254

Description: aldehyde dehydrogenase 1 family member A3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 31.8561
    Cell Significance Index: -15.0400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 4.5417
    Cell Significance Index: 47.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1534
    Cell Significance Index: -9.0900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.2131
    Cell Significance Index: 19.8900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.9166
    Cell Significance Index: 151.5100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.4304
    Cell Significance Index: 313.9900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1102
    Cell Significance Index: 52.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0249
    Cell Significance Index: 131.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9763
    Cell Significance Index: 45.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.7660
    Cell Significance Index: 20.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7634
    Cell Significance Index: 14.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5382
    Cell Significance Index: 102.4200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.4922
    Cell Significance Index: 10.5200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4394
    Cell Significance Index: 22.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3475
    Cell Significance Index: 34.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3230
    Cell Significance Index: 291.6100
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.2780
    Cell Significance Index: 2.8700
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 0.2194
    Cell Significance Index: 1.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2034
    Cell Significance Index: 15.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2031
    Cell Significance Index: 1.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1894
    Cell Significance Index: 103.4300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1710
    Cell Significance Index: 27.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1565
    Cell Significance Index: 4.4900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1370
    Cell Significance Index: 16.8400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.1356
    Cell Significance Index: 1.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0804
    Cell Significance Index: 11.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0711
    Cell Significance Index: 7.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0671
    Cell Significance Index: 7.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0646
    Cell Significance Index: 2.9300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0559
    Cell Significance Index: 10.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0489
    Cell Significance Index: 30.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0381
    Cell Significance Index: 58.6300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0323
    Cell Significance Index: 0.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0318
    Cell Significance Index: 20.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0303
    Cell Significance Index: 6.0800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0295
    Cell Significance Index: 0.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0242
    Cell Significance Index: 2.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0163
    Cell Significance Index: 2.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0133
    Cell Significance Index: 0.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0048
    Cell Significance Index: -9.0300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0061
    Cell Significance Index: -11.2900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0069
    Cell Significance Index: -5.1400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0076
    Cell Significance Index: -0.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0088
    Cell Significance Index: -3.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0094
    Cell Significance Index: -12.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0096
    Cell Significance Index: -5.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0103
    Cell Significance Index: -0.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0159
    Cell Significance Index: -0.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0178
    Cell Significance Index: -13.4500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0184
    Cell Significance Index: -0.4600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0208
    Cell Significance Index: -15.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0298
    Cell Significance Index: -1.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0316
    Cell Significance Index: -9.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0343
    Cell Significance Index: -15.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0370
    Cell Significance Index: -13.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0375
    Cell Significance Index: -7.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0554
    Cell Significance Index: -1.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0621
    Cell Significance Index: -7.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0627
    Cell Significance Index: -12.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0974
    Cell Significance Index: -3.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0981
    Cell Significance Index: -14.2600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1107
    Cell Significance Index: -0.7500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1120
    Cell Significance Index: -1.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1129
    Cell Significance Index: -6.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1323
    Cell Significance Index: -13.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1426
    Cell Significance Index: -16.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1591
    Cell Significance Index: -16.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1651
    Cell Significance Index: -11.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1668
    Cell Significance Index: -4.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1723
    Cell Significance Index: -9.6700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1799
    Cell Significance Index: -3.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1915
    Cell Significance Index: -15.1700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1919
    Cell Significance Index: -3.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2201
    Cell Significance Index: -14.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2227
    Cell Significance Index: -4.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2320
    Cell Significance Index: -14.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2342
    Cell Significance Index: -17.9800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2706
    Cell Significance Index: -5.9300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2836
    Cell Significance Index: -17.4300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2929
    Cell Significance Index: -12.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3018
    Cell Significance Index: -11.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3027
    Cell Significance Index: -8.4600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3079
    Cell Significance Index: -4.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3108
    Cell Significance Index: -7.9900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3226
    Cell Significance Index: -11.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3371
    Cell Significance Index: -9.9300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3429
    Cell Significance Index: -5.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3583
    Cell Significance Index: -8.6800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3607
    Cell Significance Index: -2.2200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3627
    Cell Significance Index: -4.1200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.3661
    Cell Significance Index: -4.7200
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: -0.3713
    Cell Significance Index: -4.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3784
    Cell Significance Index: -19.8700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4008
    Cell Significance Index: -17.7300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4317
    Cell Significance Index: -15.0000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4575
    Cell Significance Index: -14.9800
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: -0.4671
    Cell Significance Index: -2.6000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4728
    Cell Significance Index: -17.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4760
    Cell Significance Index: -15.1600
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.5081
    Cell Significance Index: -4.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Aldehyde Dehydrogenase Activity:** ALDH1A3 exhibits potent aldehyde dehydrogenase activity, converting retinaldehyde to retinoic acid, a crucial signaling molecule in development and differentiation. 2. **Apoptosis Regulation:** ALDH1A3 is involved in the regulation of apoptotic processes, influencing cell survival and death in response to various stimuli. 3. **Embryonic Development:** ALDH1A3 is essential for embryonic development, particularly in the formation of the eye, face, and inner ear. 4. **Cellular Localization:** ALDH1A3 is predominantly expressed in epithelial cells, neurons, and immune cells, suggesting its role in maintaining tissue homeostasis and regulating immune responses. **Pathways and Functions:** 1. **Aldehyde Dehydrogenase (NAD+ Activity):** ALDH1A3 catalyzes the conversion of retinaldehyde to retinoic acid, a key step in the retinoic acid biosynthetic pathway. 2. **Apoptotic Process:** ALDH1A3 regulates apoptosis by modulating the activity of pro-apoptotic and anti-apoptotic proteins. 3. **Embryonic Camera-Type Eye Development:** ALDH1A3 is essential for the development of the camera-type eye, influencing the formation of the optic cup and retina. 4. **Signaling by Nuclear Receptors:** ALDH1A3 interacts with nuclear receptors, modulating the activity of retinoic acid receptors and influencing gene expression. **Clinical Significance:** 1. **Cancer Therapy:** ALDH1A3's role in apoptosis and cell survival makes it a potential target for cancer therapy, particularly in the treatment of cancers with high ALDH1A3 expression. 2. **Neurological Disorders:** ALDH1A3's involvement in retinal development and function suggests its potential role in neurodegenerative diseases, such as retinitis pigmentosa and Alzheimer's disease. 3. **Immunological Disorders:** ALDH1A3's expression in immune cells and its involvement in apoptosis regulation make it a potential target for the treatment of autoimmune diseases and immunodeficiencies. 4. **Developmental Abnormalities:** ALDH1A3's essential role in embryonic development highlights its potential as a therapeutic target for congenital abnormalities and developmental disorders. In conclusion, ALDH1A3 is a multifaceted gene with significant implications for various cellular processes, including apoptosis, embryonic development, and retinoid metabolism. Its involvement in multiple signaling pathways underscores its importance in maintaining cellular homeostasis and regulating complex physiological processes. Further research is necessary to fully elucidate the clinical significance of ALDH1A3 and its potential applications in human disease.

Genular Protein ID: 3587866517

Symbol: AL1A3_HUMAN

Name: Retinaldehyde dehydrogenase 3

UniProtKB Accession Codes:

P47895 Q6NT64

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 23 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 27 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7698756

Title: Molecular cloning, genomic organization, and chromosomal localization of an additional human aldehyde dehydrogenase gene, ALDH6.

PubMed ID: 7698756

DOI: 10.1006/geno.1994.1624

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23591992

Title: ALDH1A3 loss of function causes bilateral anophthalmia/microphthalmia and hypoplasia of the optic nerve and optic chiasm.

PubMed ID: 23591992

DOI: 10.1093/hmg/ddt179

PubMed ID: 27759097

Title: Crystal structure of human aldehyde dehydrogenase 1A3 complexed with NAD(+) and retinoic acid.

PubMed ID: 27759097

DOI: 10.1038/srep35710

PubMed ID: 23312594

Title: ALDH1A3 mutations cause recessive anophthalmia and microphthalmia.

PubMed ID: 23312594

DOI: 10.1016/j.ajhg.2012.12.003

PubMed ID: 23646827

Title: Mutations in ALDH1A3 cause Microphthalmia.

PubMed ID: 23646827

DOI: 10.1111/cge.12184

PubMed ID: 24568872

Title: Novel splice-site and missense mutations in the ALDH1A3 gene underlying autosomal recessive anophthalmia/microphthalmia.

PubMed ID: 24568872

DOI: 10.1136/bjophthalmol-2013-304058

PubMed ID: 24024553

Title: A homozygous mutation in a consanguineous family consolidates the role of ALDH1A3 in autosomal recessive microphthalmia.

PubMed ID: 24024553

DOI: 10.1111/cge.12277

PubMed ID: 23881059

Title: A missense mutation in ALDH1A3 causes isolated microphthalmia/anophthalmia in nine individuals from an inbred Muslim kindred.

PubMed ID: 23881059

DOI: 10.1038/ejhg.2013.157

PubMed ID: 24777706

Title: Mutations in ALDH1A3 represent a frequent cause of microphthalmia/anophthalmia in consanguineous families.

PubMed ID: 24777706

DOI: 10.1002/humu.22580

Sequence Information:

  • Length: 512
  • Mass: 56108
  • Checksum: 1BFCF4F56F0FE89A
  • Sequence:
    • MATANGAVEN GQPDRKPPAL PRPIRNLEVK FTKIFINNEW HESKSGKKFA TCNPSTREQI 
CEVEEGDKPD VDKAVEAAQV AFQRGSPWRR LDALSRGRLL HQLADLVERD RATLAALETM 
DTGKPFLHAF FIDLEGCIRT LRYFAGWADK IQGKTIPTDD NVVCFTRHEP IGVCGAITPW 
NFPLLMLVWK LAPALCCGNT MVLKPAEQTP LTALYLGSLI KEAGFPPGVV NIVPGFGPTV 
GAAISSHPQI NKIAFTGSTE VGKLVKEAAS RSNLKRVTLE LGGKNPCIVC ADADLDLAVE 
CAHQGVFFNQ GQCCTAASRV FVEEQVYSEF VRRSVEYAKK RPVGDPFDVK TEQGPQIDQK 
QFDKILELIE SGKKEGAKLE CGGSAMEDKG LFIKPTVFSE VTDNMRIAKE EIFGPVQPIL 
KFKSIEEVIK RANSTDYGLT AAVFTKNLDK ALKLASALES GTVWINCYNA LYAQAPFGGF 
KMSGNGRELG EYALAEYTEV KTVTIKLGDK NP

Genular Protein ID: 732464347

Symbol: H0Y2X5_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0Y2X5

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 1 GeneTree 1 HGNC 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 405
  • Mass: 44256
  • Checksum: CE65AE95A0149C63
  • Sequence:
    • MATANGAVEN GQPDRKPPAL PRPIRNLEVK FTKIFINNEW HESKSGKKFA TCNPSTREQI 
CEVEEGDKPD VDKAVEAAQV AFQRGSPWRR LDALSRGRLL HQLADLVERD RATLAAGFPP 
GVVNIVPGFG PTVGAAISSH PQINKIAFTG STEVGKLVKE AASRSNLKRV TLELGGKNPC 
IVCADADLDL AVECAHQGVF FNQGQCCTAA SRVFVEEQVY SEFVRRSVEY AKKRPVGDPF 
DVKTEQGPQI DQKQFDKILE LIESGKKEGA KLECGGSAME DKGLFIKPTV FSEVTDNMRI 
AKEEIFGPVQ PILKFKSIEE VIKRANSTDY GLTAAVFTKN LDKALKLASA LESGTVWINC 
YNALYAQAPF GGFKMSGNGR ELGEYALAEY TEVKTVTIKL GDKNP

Genular Protein ID: 3225247372

Symbol: Q7Z3A2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7Z3A2

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 416
  • Mass: 45435
  • Checksum: BBF5DB0FA5C68D6D
  • Sequence:
    • RAPRARERGG AMATANGAVE NGQPDRKPPA LPRPIRNLEV KFTKIFINNE WHESKSGKKF 
ATCNPSTREQ ICEVEEGDKP DVDKAVEAAQ VAFQRGSPWR RLDALSRGRL LHQLADLVER 
DRATLAAGFP PGVVNIVPGF GPTVGAAISS HPQINKIAFT GSTEVGKLVK EAASRSNLKR 
VTLELGGKNP CIVCADADLD LAVECAHQGV FFNQGQCCTA ASRVFVEEQV YSEFVRRSVE 
YAKKRPVGDP FDVKTEQGPQ IDQKQFDKIL ELIESGKKEG AKLECGGSAM EDKGLFIKPT 
VFSEVTDNMR IAKEEIFGPV QPILKFKSIE EVIKRANSTD YGLTAAVFTK NLDKALKLAS 
ALESGTVWIN CYNALYAQAP FGGFKMSGNG RELGEYALAE YTEVKTVTIK LGDKNP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.