Genular: Defining Cellular Identity and Function

Details for: Traf1

Gene ID: 22029

Symbol: Traf1

Ensembl ID: ENSMUSG00000026875

Description: TNF receptor-associated factor 1

Associated with

Death receptor signaling
(R-MMU-73887)
Regulation of tnfr1 signaling
(R-MMU-5357905)
Tnfr1-induced nf-kappa-b signaling pathway
(R-MMU-5357956)
Tnf signaling
(R-MMU-75893)
Apoptotic process
(GO:0006915)
Cytoplasm
(GO:0005737)
Cytoplasmic side of plasma membrane
(GO:0009898)
Identical protein binding
(GO:0042802)
Plasma membrane signaling receptor complex
(GO:0098802)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Protein binding
(GO:0005515)
Protein k63-linked ubiquitination
(GO:0070534)
Regulation of apoptotic process
(GO:0042981)
Regulation of canonical nf-kappab signal transduction
(GO:0043122)
Regulation of extrinsic apoptotic signaling pathway
(GO:2001236)
Signal transduction
(GO:0007165)
Thioesterase binding
(GO:0031996)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Tumor necrosis factor receptor binding
(GO:0005164)
Ubiquitin protein ligase binding
(GO:0031625)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

TNF receptor-associated factor 1

Genular Protein ID: 2874607583

Symbol: TRAF1_MOUSE

Name: TNF receptor-associated factor 1

UniProtKB Accession Codes:

P39428 Q8CE28

Database IDs:

Citations:

PubMed ID: 8069916

Title: A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.

PubMed ID: 8069916

DOI: 10.1016/0092-8674(94)90532-0

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 9104814

Title: TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.

PubMed ID: 9104814

DOI: 10.1084/jem.185.7.1275

PubMed ID: 11672546

Title: TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice.

PubMed ID: 11672546

DOI: 10.1016/s1074-7613(01)00207-2

PubMed ID: 11804591

Title: A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2.

PubMed ID: 11804591

DOI: 10.1016/s1097-2765(01)00434-8

PubMed ID: 16352630

Title: TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45.

PubMed ID: 16352630

DOI: 10.1093/intimm/dxh354

PubMed ID: 18429822

Title: Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.

PubMed ID: 18429822

DOI: 10.1111/j.1365-2443.2008.01182.x

PubMed ID: 18849341

Title: FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.

PubMed ID: 18849341

DOI: 10.1074/jbc.m806923200

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 22424771

Title: A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2.

PubMed ID: 22424771

DOI: 10.1016/j.molcel.2012.01.025

PubMed ID: 23542741

Title: A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.

PubMed ID: 23542741

DOI: 10.1038/ni.2565

Sequence Information:

Length: 409
Mass: 45465
Checksum: ADD7F997169D9AAD
Sequence:

MASSSAPDEN EFQFGCPPAP CQDPSEPRVL CCTACLSENL RDDEDRICPK CRADNLHPVS 
PGSPLTQEKV HSDVAEAEIM CPFAGVGCSF KGSPQSMQEH EATSQSSHLY LLLAVLKEWK 
SSPGSNLGSA PMALERNLSE LQLQAAVEAT GDLEVDCYRA PCCESQEELA LQHLVKEKLL 
AQLEEKLRVF ANIVAVLNKE VEASHLALAA SIHQSQLDRE HILSLEQRVV ELQQTLAQKD 
QVLGKLEHSL RLMEEASFDG TFLWKITNVT KRCHESVCGR TVSLFSPAFY TAKYGYKLCL 
RLYLNGDGSG KKTHLSLFIV IMRGEYDALL PWPFRNKVTF MLLDQNNREH AIDAFRPDLS 
SASFQRPQSE TNVASGCPLF FPLSKLQSPK HAYVKDDTMF LKCIVDTSA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Traf1

Associated with

Other Information

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. PubMed ID: 8069916

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. PubMed ID: 9104814

TRAF1 is a negative regulator of TNF signaling. enhanced TNF signaling in TRAF1-deficient mice. PubMed ID: 11672546

A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2. PubMed ID: 11804591

TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45. PubMed ID: 16352630

Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1. PubMed ID: 18429822

FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway. PubMed ID: 18849341

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. PubMed ID: 22424771

A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. PubMed ID: 23542741