Genular: Defining Cellular Identity and Function

Details for: Traf2

Gene ID: 22030

Symbol: Traf2

Ensembl ID: ENSMUSG00000026942

Description: TNF receptor-associated factor 2

Associated with

Apoptosis
(R-MMU-109581)
Casp8 activity is inhibited
(R-MMU-5218900)
Caspase activation via death receptors in the presence of ligand
(R-MMU-140534)
Caspase activation via extrinsic apoptotic signalling pathway
(R-MMU-5357769)
Cytokine signaling in immune system
(R-MMU-1280215)
Death receptor signaling
(R-MMU-73887)
Deubiquitination
(R-MMU-5688426)
Dimerization of procaspase-8
(R-MMU-69416)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Metabolism of proteins
(R-MMU-392499)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Post-translational protein modification
(R-MMU-597592)
Programmed cell death
(R-MMU-5357801)
Regulated necrosis
(R-MMU-5218859)
Regulation by c-flip
(R-MMU-3371378)
Regulation of necroptotic cell death
(R-MMU-5675482)
Regulation of nf-kappa b signaling
(R-MMU-9758274)
Regulation of tnfr1 signaling
(R-MMU-5357905)
Ripk1-mediated regulated necrosis
(R-MMU-5213460)
Signaling by interleukins
(R-MMU-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-MMU-445989)
Tnfr1-induced nf-kappa-b signaling pathway
(R-MMU-5357956)
Tnfr1-induced proapoptotic signaling
(R-MMU-5357786)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
(R-MMU-5676594)
Tnf signaling
(R-MMU-75893)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Ub-specific processing proteases
(R-MMU-5689880)
Activation of nf-kappab-inducing kinase activity
(GO:0007250)
Apoptotic process
(GO:0006915)
Cd40 receptor binding
(GO:0005174)
Cellular response to nitric oxide
(GO:0071732)
Enzyme binding
(GO:0019899)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Lipid binding
(GO:0008289)
Metal ion binding
(GO:0046872)
Mitogen-activated protein kinase kinase kinase binding
(GO:0031435)
Molecular adaptor activity
(GO:0060090)
Mrna stabilization
(GO:0048255)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of glial cell apoptotic process
(GO:0034351)
Non-canonical nf-kappab signal transduction
(GO:0038061)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of t cell cytokine production
(GO:0002726)
Programmed necrotic cell death
(GO:0097300)
Protein-containing complex assembly
(GO:0065003)
Protein-containing complex binding
(GO:0044877)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein autoubiquitination
(GO:0051865)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein k63-linked ubiquitination
(GO:0070534)
Protein kinase binding
(GO:0019901)
Protein phosphatase binding
(GO:0019903)
Regulation of apoptotic process
(GO:0042981)
Regulation of immunoglobulin production
(GO:0002637)
Regulation of jnk cascade
(GO:0046328)
Regulation of protein-containing complex assembly
(GO:0043254)
Signaling adaptor activity
(GO:0035591)
Signal transduction
(GO:0007165)
Signal transduction involved in regulation of gene expression
(GO:0023019)
Sphingolipid binding
(GO:0046625)
Thioesterase binding
(GO:0031996)
Transferase activity
(GO:0016740)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Tumor necrosis factor binding
(GO:0043120)
Tumor necrosis factor receptor binding
(GO:0005164)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase binding
(GO:0031625)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

TNF receptor-associated factor 2
Q8C6X9_MOUSE

Genular Protein ID: 1663989055

Symbol: TRAF2_MOUSE

Name: TNF receptor-associated factor 2

UniProtKB Accession Codes:

P39429 A2AJA3 O54896

Database IDs:

Citations:

PubMed ID: 8069916

Title: A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor.

PubMed ID: 8069916

DOI: 10.1016/0092-8674(94)90532-0

PubMed ID: 9461607

Title: Tumor necrosis factor receptor (TNFR)-associated factor 2A (TRAF2A), a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2-mediated NF-kappaB activation.

PubMed ID: 9461607

DOI: 10.1074/jbc.273.7.4129

PubMed ID: 11275257

Title: Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants.

PubMed ID: 11275257

DOI: 10.1016/s0161-5890(00)00098-5

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8565075

Title: TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways.

PubMed ID: 8565075

DOI: 10.1016/s0092-8674(00)80984-8

PubMed ID: 8692885

Title: The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation.

PubMed ID: 8692885

DOI: 10.1073/pnas.93.13.6721

PubMed ID: 9390694

Title: Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice.

PubMed ID: 9390694

DOI: 10.1016/s1074-7613(00)80391-x

PubMed ID: 9500555

Title: Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway.

PubMed ID: 9500555

DOI: 10.1038/ng0398-287

PubMed ID: 9104814

Title: TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.

PubMed ID: 9104814

DOI: 10.1084/jem.185.7.1275

PubMed ID: 10514016

Title: TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses.

PubMed ID: 10514016

DOI: 10.1016/s1074-7613(00)80113-2

PubMed ID: 11340079

Title: FLASH coordinates NF-kappa B activity via TRAF2.

PubMed ID: 11340079

DOI: 10.1074/jbc.m102941200

PubMed ID: 11435475

Title: Tumor necrosis factor receptor-associated factor (TRAF)2 represses the T helper cell type 2 response through interaction with NFAT-interacting protein (NIP45).

PubMed ID: 11435475

DOI: 10.1084/jem.194.1.89

PubMed ID: 11909853

Title: Regulation of TRAF2 signaling by self-induced degradation.

PubMed ID: 11909853

DOI: 10.1074/jbc.m111522200

PubMed ID: 11804591

Title: A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2.

PubMed ID: 11804591

DOI: 10.1016/s1097-2765(01)00434-8

PubMed ID: 15175328

Title: The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2.

PubMed ID: 15175328

DOI: 10.1074/jbc.m404206200

PubMed ID: 15121867

Title: TRAF family proteins link PKR with NF-kappa B activation.

PubMed ID: 15121867

DOI: 10.1128/mcb.24.10.4502-4512.2004

PubMed ID: 16876162

Title: TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH(2)-terminal kinase and transcription factor AP-1.

PubMed ID: 16876162

DOI: 10.1016/j.febslet.2006.06.098

PubMed ID: 18281285

Title: AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response.

PubMed ID: 18281285

DOI: 10.1074/jbc.m710557200

PubMed ID: 18849341

Title: FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.

PubMed ID: 18849341

DOI: 10.1074/jbc.m806923200

PubMed ID: 18997792

Title: Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.

PubMed ID: 18997792

DOI: 10.1038/ni.1678

PubMed ID: 18997794

Title: Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

PubMed ID: 18997794

DOI: 10.1038/ni.1676

PubMed ID: 19150425

Title: PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination.

PubMed ID: 19150425

DOI: 10.1016/j.molcel.2008.11.023

PubMed ID: 19506082

Title: Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2.

PubMed ID: 19506082

DOI: 10.1074/jbc.m109.029983

PubMed ID: 19815541

Title: TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (TNF) to efficiently activate NF-{kappa}B and to prevent TNF-induced apoptosis.

PubMed ID: 19815541

DOI: 10.1074/jbc.m109.072256

PubMed ID: 19409903

Title: TRAF2 suppresses basal IKK activity in resting cells and TNFalpha can activate IKK in TRAF2 and TRAF5 double knockout cells.

PubMed ID: 19409903

DOI: 10.1016/j.jmb.2009.04.054

PubMed ID: 20185725

Title: Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes.

PubMed ID: 20185725

DOI: 10.1126/science.1182364

PubMed ID: 21307340

Title: UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation.

PubMed ID: 21307340

DOI: 10.1091/mbc.e10-10-0827

PubMed ID: 22424771

Title: A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2.

PubMed ID: 22424771

DOI: 10.1016/j.molcel.2012.01.025

PubMed ID: 23542741

Title: A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.

PubMed ID: 23542741

DOI: 10.1038/ni.2565

PubMed ID: 25026888

Title: LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria.

PubMed ID: 25026888

DOI: 10.1038/ncomms5434

Sequence Information:

Length: 501
Mass: 56026
Checksum: 043B391180365F10
Sequence:

MAAASVTSPG SLELLQPGFS KTLLGTRLEA KYLCSACKNI LRRPFQAQCG HRYCSFCLTS 
ILSSGPQNCA ACVYEGLYEE GISILESSSA FPDNAARREV ESLPAVCPND GCTWKGTLKE 
YESCHEGLCP FLLTECPACK GLVRLSEKEH HTEQECPKRS LSCQHCRAPC SHVDLEVHYE 
VCPKFPLTCD GCGKKKIPRE TFQDHVRACS KCRVLCRFHT VGCSEMVETE NLQDHELQRL 
REHLALLLSS FLEAQASPGT LNQVGPELLQ RCQILEQKIA TFENIVCVLN REVERVAVTA 
EACSRQHRLD QDKIEALSNK VQQLERSIGL KDLAMADLEQ KVSELEVSTY DGVFIWKISD 
FTRKRQEAVA GRTPAIFSPA FYTSRYGYKM CLRVYLNGDG TGRGTHLSLF FVVMKGPNDA 
LLQWPFNQKV TLMLLDHNNR EHVIDAFRPD VTSSSFQRPV SDMNIASGCP LFCPVSKMEA 
KNSYVRDDAI FIKAIVDLTG L

Genular Protein ID: 558136895

Symbol: Q8C6X9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8C6X9

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 501
Mass: 56086
Checksum: 89DDCB177B2BBF1F
Sequence:

MAAASVTSPG SLELLQPGFS KTLLGTRLEA KYLCSACKNI LRRPFQAQCG HRYCSFCLTS 
ILSSGPQNCA ACVYEGLYEE GISILESSSA FPDNAARREV ESLPAVCPND GCTWKGTLKE 
YESCHEGLCP FLLTECPACK GLVRLSEKEH HTEQECPKRS LSCQHCRAPC SHVDLEVHYE 
VCPKFPLTYD GCGKKKIPRE TFQDHVRACS KCRVLCRFHT VGCSEMVETE NLQDHELQRL 
REHLALLLSS FLEAQASPGT LNQVGPELLQ RCQILEQKIA TFENIVCVLN REVERVAVTA 
EACSRQHRLD QDKIEALSNK VQQLERSIGL KDLAMADLEQ KVSELEVSTY DGVFIWKISD 
FTRKRQEAVA GRTPAIFSPA FYTSRYGYKM CLRVYLNGDG TGRGTHLSLF FVVMKGPNDA 
LLQWPFNQKV TLMLLDHNNR EHVIDAFRPD VTSSSFQRPV SDMNIASGCP LFCPVSKMEA 
KNSYVRDDAI FIKAIVDLTG L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Traf2

Associated with

Other Information

A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. PubMed ID: 8069916

Tumor necrosis factor receptor (TNFR)-associated factor 2A (TRAF2A), a TRAF2 splice variant with an extended RING finger domain that inhibits TNFR2-mediated NF-kappaB activation. PubMed ID: 9461607

Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants. PubMed ID: 11275257

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. PubMed ID: 8565075

The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. PubMed ID: 8692885

Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. PubMed ID: 9390694

Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway. PubMed ID: 9500555

TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. PubMed ID: 9104814

TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses. PubMed ID: 10514016

FLASH coordinates NF-kappa B activity via TRAF2. PubMed ID: 11340079

Tumor necrosis factor receptor-associated factor (TRAF)2 represses the T helper cell type 2 response through interaction with NFAT-interacting protein (NIP45). PubMed ID: 11435475

Regulation of TRAF2 signaling by self-induced degradation. PubMed ID: 11909853

A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2. PubMed ID: 11804591

The kinase activity of Rip1 is not required for tumor necrosis factor-alpha-induced IkappaB kinase or p38 MAP kinase activation or for the ubiquitination of Rip1 by Traf2. PubMed ID: 15175328

TRAF family proteins link PKR with NF-kappa B activation. PubMed ID: 15121867

TRUSS, a tumor necrosis factor receptor-1-interacting protein, activates c-Jun NH(2)-terminal kinase and transcription factor AP-1. PubMed ID: 16876162

AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response. PubMed ID: 18281285

FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway. PubMed ID: 18849341

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. PubMed ID: 18997792

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. PubMed ID: 18997794

PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination. PubMed ID: 19150425

Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2. PubMed ID: 19506082

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (TNF) to efficiently activate NF-{kappa}B and to prevent TNF-induced apoptosis. PubMed ID: 19815541

TRAF2 suppresses basal IKK activity in resting cells and TNFalpha can activate IKK in TRAF2 and TRAF5 double knockout cells. PubMed ID: 19409903

Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes. PubMed ID: 20185725

UXT-V1 protects cells against TNF-induced apoptosis through modulating complex II formation. PubMed ID: 21307340

A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. PubMed ID: 22424771

A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. PubMed ID: 23542741

LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria. PubMed ID: 25026888

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073