Genular: Defining Cellular Identity and Function

Details for: Traf3

Gene ID: 22031

Symbol: Traf3

Ensembl ID: ENSMUSG00000021277

Description: TNF receptor-associated factor 3

Associated with

Activation of irf3, irf7 mediated by tbk1, ikbke
(R-MMU-936964)
Cytokine signaling in immune system
(R-MMU-1280215)
Deubiquitination
(R-MMU-5688426)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Metabolism of proteins
(R-MMU-392499)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Ovarian tumor domain proteases
(R-MMU-5689896)
Post-translational protein modification
(R-MMU-597592)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Tnf receptor superfamily (tnfsf) members mediating non-canonical nf-kb pathway
(R-MMU-5676594)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Apoptotic process
(GO:0006915)
Cd40 receptor complex
(GO:0035631)
Cytoplasm
(GO:0005737)
Cytoplasmic side of plasma membrane
(GO:0009898)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Plasma membrane signaling receptor complex
(GO:0098802)
Positive regulation of type i interferon production
(GO:0032481)
Protein binding
(GO:0005515)
Protein k63-linked ubiquitination
(GO:0070534)
Protein kinase binding
(GO:0019901)
Protein phosphatase binding
(GO:0019903)
Regulation of apoptotic process
(GO:0042981)
Regulation of canonical nf-kappab signal transduction
(GO:0043122)
Regulation of cytokine production
(GO:0001817)
Regulation of defense response to virus
(GO:0050688)
Regulation of interferon-beta production
(GO:0032648)
Regulation of proteolysis
(GO:0030162)
Signal transduction
(GO:0007165)
Thioesterase binding
(GO:0031996)
Toll-like receptor 4 signaling pathway
(GO:0034142)
Toll-like receptor signaling pathway
(GO:0002224)
Toll signaling pathway
(GO:0008063)
Transferase activity
(GO:0016740)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Tumor necrosis factor receptor binding
(GO:0005164)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)
Ubiquitin protein ligase binding
(GO:0031625)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

TRAF3_MOUSE
Q3UHJ1_MOUSE

Genular Protein ID: 2811703816

Symbol: TRAF3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q60803 B2RPW3 Q62380

Database IDs:

Citations:

PubMed ID: 7533327

Title: Involvement of CRAF1, a relative of TRAF, in CD40 signaling.

PubMed ID: 7533327

DOI: 10.1126/science.7533327

PubMed ID: 8660894

Title: A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein.

PubMed ID: 8660894

DOI: 10.1006/dbio.1996.0162

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8934568

Title: Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses.

PubMed ID: 8934568

DOI: 10.1016/s1074-7613(00)80497-5

PubMed ID: 17015635

Title: Rescue of TRAF3-null mice by p100 NF-kappa B deficiency.

PubMed ID: 17015635

DOI: 10.1084/jem.20061166

PubMed ID: 16306937

Title: Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6.

PubMed ID: 16306937

DOI: 10.1038/nature04369

PubMed ID: 16306936

Title: Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response.

PubMed ID: 16306936

DOI: 10.1038/nature04374

PubMed ID: 17158868

Title: Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway.

PubMed ID: 17158868

DOI: 10.1074/jbc.m610271200

PubMed ID: 17723217

Title: Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs.

PubMed ID: 17723217

DOI: 10.1016/j.immuni.2007.07.012

PubMed ID: 18313334

Title: TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor.

PubMed ID: 18313334

DOI: 10.1016/j.immuni.2008.01.009

PubMed ID: 18849341

Title: FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.

PubMed ID: 18849341

DOI: 10.1074/jbc.m806923200

PubMed ID: 18997792

Title: Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling.

PubMed ID: 18997792

DOI: 10.1038/ni.1678

PubMed ID: 18997794

Title: Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

PubMed ID: 18997794

DOI: 10.1038/ni.1676

PubMed ID: 19228877

Title: TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40.

PubMed ID: 19228877

DOI: 10.1093/intimm/dxp013

PubMed ID: 19898473

Title: Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines.

PubMed ID: 19898473

DOI: 10.1038/ni.1819

PubMed ID: 23871208

Title: The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.

PubMed ID: 23871208

DOI: 10.1016/j.immuni.2013.06.013

PubMed ID: 23334419

Title: OTUD7B controls non-canonical NF-kappaB activation through deubiquitination of TRAF3.

PubMed ID: 23334419

DOI: 10.1038/nature11831

PubMed ID: 23542741

Title: A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.

PubMed ID: 23542741

DOI: 10.1038/ni.2565

PubMed ID: 26474655

Title: Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes.

PubMed ID: 26474655

DOI: 10.1016/j.immuni.2015.09.010

PubMed ID: 26029823

Title: Catalytic subunits of the phosphatase calcineurin interact with NF-kappaB-inducing kinase (NIK) and attenuate NIK-dependent gene expression.

PubMed ID: 26029823

DOI: 10.1038/srep10758

PubMed ID: 26305951

Title: Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6.

PubMed ID: 26305951

DOI: 10.1073/pnas.1509968112

PubMed ID: 30579117

Title: USP25 promotes endotoxin tolerance via suppressing K48-linked ubiquitination and degradation of TRAF3 in Kupffer cells.

PubMed ID: 30579117

DOI: 10.1016/j.molimm.2018.12.017

PubMed ID: 23150880

Title: Single amino acid substitutions confer the antiviral activity of the TRAF3 adaptor protein onto TRAF5.

PubMed ID: 23150880

DOI: 10.1126/scisignal.2003152

Sequence Information:

Length: 567
Mass: 64294
Checksum: EC282EFFF84E5A3F
Sequence:

MESSKKMDAA GTLQPNPPLK LQPDRGAGSV LVPEQGGYKE KFVKTVEDKY KCEKCRLVLC 
NPKQTECGHR FCESCMAALL SSSSPKCTAC QESIIKDKVF KDNCCKREIL ALQVYCRNEG 
RGCAEQLTLG HLLVHLKNEC QFEELPCLRA DCKEKVLRKD LRDHVEKACK YREATCSHCK 
SQVPMIKLQK HEDTDCPCVV VSCPHKCSVQ TLLRSELSAH LSECVNAPST CSFKRYGCVF 
QGTNQQIKAH EASSAVQHVN LLKEWSNSLE KKVSLLQNES VEKNKSIQSL HNQICSFEIE 
IERQKEMLRN NESKILHLQR VIDSQAEKLK ELDKEIRPFR QNWEEADSMK SSVESLQNRV 
TELESVDKSA GQAARNTGLL ESQLSRHDQM LSVHDIRLAD MDLRFQVLET ASYNGVLIWK 
IRDYKRRKQE AVMGKTLSLY SQPFYTGYFG YKMCARVYLN GDGMGKGTHL SLFFVIMRGE 
YDALLPWPFK QKVTLMLMDQ GSSRRHLGDA FKPDPNSSSF KKPTGEMNIA SGCPVFVAQT 
VLENGTYIKD DTIFIKVIVD TSDLPDP

Genular Protein ID: 3293435068

Symbol: Q3UHJ1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UHJ1

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 542
Mass: 61564
Checksum: 63DF0A68EF3422A8
Sequence:

MESSKKMDAA GTLQPNPPLK LQPDRGAGSV LVPEQGGYKE KFVKTVEDKY KCEKCRLVLC 
NPKQTECGHR FCESCMAALL SSSSPKCTAC QESIIKDKVF KDNCCKREIL ALQVYCRNEG 
RGCAEQLTLG HLLVHLKNEC QFEELPCLRA DCKEKVLRKD LRDHVEKACK YREATCSHCK 
SQVPMIKLQK HEDTDCPCVV VSCPHKCSVQ TLLRSEGTNQ QIKAHEASSA VQHVNLLKEW 
SNSLEKKVSL LQNESVEKNK SIQSLHNQIC SFEIEIERQK EMLRNNESKI LHLQRVIDSQ 
AEKLKELDKE IRPFRQNWEE ADSMKSSVES LQNRVTELES VDKSAGQAAR NTGLLESQLS 
RHDQMLSVHD IRLADMDLRF QVLETASYNG VLIWKIRDYK RRKQEAVMGK TLSLYSQPFY 
TGYFGYKMCA RVYLNGDGMG KGTHLSLFFV IMRGEYDALL PWPFKQKVTL MLMDQGSSRR 
HLGDAFKPDP NSSSFKKPTG EMNIASGCPV FVAQTVLENG TYIKDDTIFI KVIVDTSDLP 
DP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Traf3

Associated with

Other Information

Involvement of CRAF1, a relative of TRAF, in CD40 signaling. PubMed ID: 7533327

A candidate gene for the amnionless gastrulation stage mouse mutation encodes a TRAF-related protein. PubMed ID: 8660894

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses. PubMed ID: 8934568

Rescue of TRAF3-null mice by p100 NF-kappa B deficiency. PubMed ID: 17015635

Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. PubMed ID: 16306937

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response. PubMed ID: 16306936

Specificity of TRAF3 in its negative regulation of the noncanonical NF-kappa B pathway. PubMed ID: 17158868

Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs. PubMed ID: 17723217

TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. PubMed ID: 18313334

FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway. PubMed ID: 18849341

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. PubMed ID: 18997792

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. PubMed ID: 18997794

TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40. PubMed ID: 19228877

Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. PubMed ID: 19898473

The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity. PubMed ID: 23871208

OTUD7B controls non-canonical NF-kappaB activation through deubiquitination of TRAF3. PubMed ID: 23334419

A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. PubMed ID: 23542741

Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes. PubMed ID: 26474655

Catalytic subunits of the phosphatase calcineurin interact with NF-kappaB-inducing kinase (NIK) and attenuate NIK-dependent gene expression. PubMed ID: 26029823

Induction of USP25 by viral infection promotes innate antiviral responses by mediating the stabilization of TRAF3 and TRAF6. PubMed ID: 26305951

USP25 promotes endotoxin tolerance via suppressing K48-linked ubiquitination and degradation of TRAF3 in Kupffer cells. PubMed ID: 30579117

Single amino acid substitutions confer the antiviral activity of the TRAF3 adaptor protein onto TRAF5. PubMed ID: 23150880

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303