Genular: Defining Cellular Identity and Function

Details for: Traf4

Gene ID: 22032

Symbol: Traf4

Ensembl ID: ENSMUSG00000017386

Description: TNF receptor associated factor 4

Associated with

Activation of nf-kappab-inducing kinase activity
(GO:0007250)
Anchoring junction
(GO:0070161)
Apoptotic process
(GO:0006915)
Bicellular tight junction
(GO:0005923)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Fibrillar center
(GO:0001650)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Multicellular organism development
(GO:0007275)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Plasma membrane signaling receptor complex
(GO:0098802)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of protein kinase activity
(GO:0045860)
Protein kinase binding
(GO:0019901)
Regulation of apoptotic process
(GO:0042981)
Regulation of canonical nf-kappab signal transduction
(GO:0043122)
Respiratory gaseous exchange by respiratory system
(GO:0007585)
Respiratory tube development
(GO:0030323)
Signal transduction
(GO:0007165)
Thioesterase binding
(GO:0031996)
Transferase activity
(GO:0016740)
Tumor necrosis factor receptor binding
(GO:0005164)
Ubiquitin protein ligase binding
(GO:0031625)
Ww domain binding
(GO:0050699)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

TNF receptor-associated factor 4

Genular Protein ID: 952119024

Symbol: TRAF4_MOUSE

Name: TNF receptor-associated factor 4

UniProtKB Accession Codes:

Q61382 Q8BHD9

Database IDs:

Citations:

PubMed ID: 9507120

Title: Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development.

PubMed ID: 9507120

DOI: 10.1016/s0925-4773(97)00192-5

PubMed ID: 11275257

Title: Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants.

PubMed ID: 11275257

DOI: 10.1016/s0161-5890(00)00098-5

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 10934170

Title: TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs.

PubMed ID: 10934170

DOI: 10.1016/s0002-9440(10)64578-6

PubMed ID: 11943846

Title: Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice.

PubMed ID: 11943846

DOI: 10.1073/pnas.052124799

PubMed ID: 16157600

Title: MEKK4 is an effector of the embryonic TRAF4 for JNK activation.

PubMed ID: 16157600

DOI: 10.1074/jbc.c500260200

PubMed ID: 18284467

Title: Characterization of immune functions in TRAF4-deficient mice.

PubMed ID: 18284467

DOI: 10.1111/j.1365-2567.2008.02810.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23542741

Title: A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.

PubMed ID: 23542741

DOI: 10.1038/ni.2565

Sequence Information:

Length: 470
Mass: 53504
Checksum: 2C99A876E98B99C5
Sequence:

MPGFDYKFLE KPKRRLLCPL CGKPMREPVQ VSTCGHRFCD TCLQEFLSEG VFKCPEDQLP 
LDYAKIYPDP ELEVQVLGLA IRCIHSEEGC RWSGPLRHLQ GHLNTCSFNV VPCPNRCPAK 
LSRRDLPAHL QHDCPKRRLK CEFCGCDFSG EAYESHEGVC PQESVYCENK CGARMMRRLL 
AQHATSECPK RTQPCAYCTK EFVYDTIQSH QYQCPRLPVP CPNQCGVGTV AREDLPTHLK 
DSCSTAFVLC PFKESGCKHR CPKLAMGRHV EESVKPHLAM MCALVSRQRQ ELQELRRELE 
ELSIGSDGVL IWKIGSYGRR LQEAKAKPNL ECFSPAFYTH KYGYKLQVSA FLNGNGSGEG 
THLSIYIRVL PGAFDNLLEW PFARRVTFSL LDQSDPGLAK PQHVTETFHP DPNWKNFQKP 
GTWRGSLDES SLGFGYPKFI SHQDIRKRNY VRDDAVFIRA SVELPRKILS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Traf4

Associated with

Other Information

Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development. PubMed ID: 9507120

Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants. PubMed ID: 11275257

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs. PubMed ID: 10934170

Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice. PubMed ID: 11943846

MEKK4 is an effector of the embryonic TRAF4 for JNK activation. PubMed ID: 16157600

Characterization of immune functions in TRAF4-deficient mice. PubMed ID: 18284467

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. PubMed ID: 23542741