Genular: Defining Cellular Identity and Function

Details for: Traf6

Gene ID: 22034

Symbol: Traf6

Ensembl ID: ENSMUSG00000027164

Description: TNF receptor-associated factor 6

Associated with

Activated tak1 mediates p38 mapk activation
(R-MMU-450302)
Adaptive immune system
(R-MMU-1280218)
Alpha-protein kinase 1 signaling pathway
(R-MMU-9645460)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Cell death signalling via nrage, nrif and nade
(R-MMU-204998)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Cytokine signaling in immune system
(R-MMU-1280215)
Death receptor signaling
(R-MMU-73887)
Deubiquitination
(R-MMU-5688426)
Downstream tcr signaling
(R-MMU-202424)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated nf-kb activation
(R-MMU-2871837)
Ikk complex recruitment mediated by rip1
(R-MMU-937041)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Interleukin-17 signaling
(R-MMU-448424)
Intracellular signaling by second messengers
(R-MMU-9006925)
Irak1 recruits ikk complex
(R-MMU-937039)
Irak1 recruits ikk complex upon tlr7/8 or 9 stimulation
(R-MMU-975144)
Irak2 mediated activation of tak1 complex
(R-MMU-937042)
Irak2 mediated activation of tak1 complex upon tlr7/8 or 9 stimulation
(R-MMU-975163)
Jnk (c-jun kinases) phosphorylation and activation mediated by activated human tak1
(R-MMU-450321)
Map kinase activation
(R-MMU-450294)
Metabolism of proteins
(R-MMU-392499)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Nf-kb is activated and signals survival
(R-MMU-209560)
Nod1/2 signaling pathway
(R-MMU-168638)
Nrif signals cell death from the nucleus
(R-MMU-205043)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-MMU-168643)
Ovarian tumor domain proteases
(R-MMU-5689896)
P75 ntr receptor-mediated signalling
(R-MMU-193704)
P75ntr recruits signalling complexes
(R-MMU-209543)
P75ntr signals via nf-kb
(R-MMU-193639)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Post-translational protein modification
(R-MMU-597592)
Regulated proteolysis of p75ntr
(R-MMU-193692)
Regulation of nf-kappa b signaling
(R-MMU-9758274)
Signaling by interleukins
(R-MMU-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-MMU-445989)
Tcr signaling
(R-MMU-202403)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Traf6-mediated induction of tak1 complex within tlr4 complex
(R-MMU-937072)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Ub-specific processing proteases
(R-MMU-5689880)
Activation of nf-kappab-inducing kinase activity
(GO:0007250)
Animal organ morphogenesis
(GO:0009887)
Autophagosome assembly
(GO:0000045)
Canonical nf-kappab signal transduction
(GO:0007249)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytoplasmic pattern recognition receptor signaling pathway
(GO:0002753)
Dna damage response
(GO:0006974)
Histone deacetylase binding
(GO:0042826)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Immune system process
(GO:0002376)
In utero embryonic development
(GO:0001701)
Jnk cascade
(GO:0007254)
Metal ion binding
(GO:0046872)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neural tube closure
(GO:0001843)
Ossification
(GO:0001503)
Positive regulation of t cell cytokine production
(GO:0002726)
Protein binding
(GO:0005515)
Protein kinase b binding
(GO:0043422)
Protein polyubiquitination
(GO:0000209)
Protein ubiquitination
(GO:0016567)
Regulation of immunoglobulin production
(GO:0002637)
Signal transduction
(GO:0007165)
Transferase activity
(GO:0016740)
Tumor necrosis factor receptor binding
(GO:0005164)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin-ubiquitin ligase activity
(GO:0034450)
Ubiquitin conjugating enzyme binding
(GO:0031624)
Ubiquitin protein ligase activity
(GO:0061630)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

TNF receptor-associated factor 6

Genular Protein ID: 689472220

Symbol: TRAF6_MOUSE

Name: TNF receptor-associated factor 6

UniProtKB Accession Codes:

P70196 Q6P9M0 Q8BLV2

Database IDs:

Citations:

PubMed ID: 8910514

Title: Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region.

PubMed ID: 8910514

DOI: 10.1074/jbc.271.46.28745

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10421844

Title: Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice.

PubMed ID: 10421844

DOI: 10.1046/j.1365-2443.1999.00265.x

PubMed ID: 10215628

Title: TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.

PubMed ID: 10215628

DOI: 10.1101/gad.13.8.1015

PubMed ID: 10747026

Title: The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway.

PubMed ID: 10747026

DOI: 10.1093/emboj/19.7.1576

PubMed ID: 10748240

Title: Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction.

PubMed ID: 10748240

DOI: 10.1084/jem.191.7.1233

PubMed ID: 11244088

Title: The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor.

PubMed ID: 11244088

DOI: 10.1074/jbc.c000869200

PubMed ID: 12060722

Title: TRAF6-deficient mice display hypohidrotic ectodermal dysplasia.

PubMed ID: 12060722

DOI: 10.1073/pnas.132636999

PubMed ID: 12881420

Title: Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40.

PubMed ID: 12881420

DOI: 10.1093/emboj/cdg386

PubMed ID: 14499111

Title: TRAF6 is a critical factor for dendritic cell maturation and development.

PubMed ID: 14499111

DOI: 10.1016/s1074-7613(03)00230-9

PubMed ID: 15322147

Title: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adapter-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling.

PubMed ID: 15322147

DOI: 10.4049/jimmunol.173.5.2913

PubMed ID: 16079148

Title: The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination.

PubMed ID: 16079148

DOI: 10.1074/jbc.c500237200

PubMed ID: 15705807

Title: Dependence of self-tolerance on TRAF6-directed development of thymic stroma.

PubMed ID: 15705807

DOI: 10.1126/science.1105677

PubMed ID: 16951688

Title: Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1.

PubMed ID: 16951688

DOI: 10.1038/ni1383

PubMed ID: 17633018

Title: Characteristics and biological functions of TRAF6.

PubMed ID: 17633018

DOI: 10.1007/978-0-387-70630-6_6

PubMed ID: 17092936

Title: The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development.

PubMed ID: 17092936

DOI: 10.1074/jbc.m607399200

PubMed ID: 18849341

Title: FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway.

PubMed ID: 18849341

DOI: 10.1074/jbc.m806923200

PubMed ID: 21435586

Title: Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.

PubMed ID: 21435586

DOI: 10.1016/j.immuni.2011.03.010

PubMed ID: 22424771

Title: A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2.

PubMed ID: 22424771

DOI: 10.1016/j.molcel.2012.01.025

PubMed ID: 23542741

Title: A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.

PubMed ID: 23542741

DOI: 10.1038/ni.2565

PubMed ID: 25026888

Title: LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria.

PubMed ID: 25026888

DOI: 10.1038/ncomms5434

PubMed ID: 27330028

Title: Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis.

PubMed ID: 27330028

DOI: 10.1016/j.jaut.2016.06.004

Sequence Information:

Length: 530
Mass: 60070
Checksum: F8389250425E4E2D
Sequence:

MSLLNCENSC GSSQSSSDCC AAMAASCSAA VKDDSVSGSA STGNLSSSFM EEIQGYDVEF 
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD 
NFAKREILSL TVKCPNKGCL QKMELRHLED HQVHCEFALV NCPQCQRPFQ KCQVNTHIIE 
DCPRRQVSCV NCAVSMAYEE KEIHDQSCPL ANIICEYCGT ILIREQMPNH YDLDCPTAPI 
PCTFSVFGCH EKMQRNHLAR HLQENTQLHM RLLAQAVHNV NLALRPCDAA SPSRGCRPED 
PNYEETIKQL ESRLVRQDHQ IRELTAKMET QSMYVGELKR TIRTLEDKVA EMEAQQCNGI 
YIWKIGNFGM HLKSQEEERP VVIHSPGFYT GRPGYKLCMR LHLQLPTAQR CANYISLFVH 
TMQGEYDSHL PWPFQGTIRL TILDQSEALI RQNHEEVMDA KPELLAFQRP TIPRNPKGFG 
YVTFMHLEAL RQGTFIKDDT LLVRCEVSTR FDMGGLRKEG FQPRSTDAGV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Traf6

Associated with

Other Information

Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. PubMed ID: 8910514

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. PubMed ID: 10421844

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. PubMed ID: 10215628

The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway. PubMed ID: 10747026

Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction. PubMed ID: 10748240

The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor. PubMed ID: 11244088

TRAF6-deficient mice display hypohidrotic ectodermal dysplasia. PubMed ID: 12060722

Tpl2 transduces CD40 and TNF signals that activate ERK and regulates IgE induction by CD40. PubMed ID: 12881420

TRAF6 is a critical factor for dendritic cell maturation and development. PubMed ID: 14499111

TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adapter-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling. PubMed ID: 15322147

The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination. PubMed ID: 16079148

Dependence of self-tolerance on TRAF6-directed development of thymic stroma. PubMed ID: 15705807

Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1. PubMed ID: 16951688

Characteristics and biological functions of TRAF6. PubMed ID: 17633018

The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development. PubMed ID: 17092936

FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway. PubMed ID: 18849341

Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells. PubMed ID: 21435586

A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. PubMed ID: 22424771

A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. PubMed ID: 23542741

LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria. PubMed ID: 25026888

Autophagy-linked FYVE containing protein WDFY3 interacts with TRAF6 and modulates RANKL-induced osteoclastogenesis. PubMed ID: 27330028