Genular: Defining Cellular Identity and Function

Details for: Traip

Gene ID: 22036

Symbol: Traip

Ensembl ID: ENSMUSG00000032586

Description: TRAF-interacting protein

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Immune system
(R-MMU-168256)
Chromosome
(GO:0005694)
Cytoplasm
(GO:0005737)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Identical protein binding
(GO:0042802)
Metal ion binding
(GO:0046872)
Negative regulation of interferon-beta production
(GO:0032688)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of tumor necrosis factor-mediated signaling pathway
(GO:0010804)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Replication fork processing
(GO:0031297)
Signal transduction
(GO:0007165)
Site of dna damage
(GO:0090734)
Transferase activity
(GO:0016740)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

TRAIP_MOUSE

Genular Protein ID: 3178679652

Symbol: TRAIP_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8VIG6 O08854 Q922M8 Q9CPP4

Database IDs:

Citations:

PubMed ID: 9104814

Title: TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation.

PubMed ID: 9104814

DOI: 10.1084/jem.185.7.1275

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17544371

Title: TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase.

PubMed ID: 17544371

DOI: 10.1016/j.bbrc.2007.05.149

PubMed ID: 17927961

Title: Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene.

PubMed ID: 17927961

DOI: 10.1016/j.bbrc.2007.09.103

PubMed ID: 22945920

Title: TRAF-interacting protein (TRIP) negatively regulates IFN-beta production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1.

PubMed ID: 22945920

DOI: 10.1084/jem.20120024

PubMed ID: 27405720

Title: TRAIP is involved in chromosome alignment and SAC regulation in mouse oocyte meiosis.

PubMed ID: 27405720

DOI: 10.1038/srep29735

PubMed ID: 33590678

Title: CUL2LRR1, TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle.

PubMed ID: 33590678

DOI: 10.15252/embr.202052164

Sequence Information:

Length: 470
Mass: 53149
Checksum: EBFABC49A9F4BF2E
Sequence:

MPIRALCTIC SDFFDHSRDV AAIHCGHTFH LQCLIQWFET APSRTCPQCR IQVGKKTIIN 
KLFFDLAQEE ENVLDAEFLK NELDSVKAQL SQKDREKRDS QAIIDTLRDT LEERNATVES 
LQNALNKAEM LCSTLKKQMK FLEQRQDETK QAREEAHRLK CKMKTMEQIE LLLQSQRSEV 
EEMIRDMGVG QSAVEQLAVY CVSLKKEYEN LKEARKATGE LADRLKKDLV SSRSKLKTLN 
TELDQAKLEL RSAQKDLQSA DQEITSLRKK LMILQGTLSL PPATNETVSR LVFESPAPVE 
MMNPRLHQPP FGDEIDLNTT FDVNTPPTQT SGSQHCLPKK LCLERARSPM QNVLKKVHKV 
SKPESQLSLG GQRCVGELDE ELAGAFPLFI RNAVLGQKQP NRTTAESRCS TDVVRIGFDG 
LGGRTKFIQP RDTTIIRPVP VKSKAKSKQK VRIKTVSSAS QPKLDTFLCQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Traip

Associated with

Other Information

TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. PubMed ID: 9104814

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase. PubMed ID: 17544371

Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene. PubMed ID: 17927961

TRAF-interacting protein (TRIP) negatively regulates IFN-beta production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. PubMed ID: 22945920

TRAIP is involved in chromosome alignment and SAC regulation in mouse oocyte meiosis. PubMed ID: 27405720

CUL2LRR1, TRAIP and p97 control CMG helicase disassembly in the mammalian cell cycle. PubMed ID: 33590678