Genular: Defining Cellular Identity and Function

Details for: Plscr1

Gene ID: 22038

Symbol: Plscr1

Ensembl ID: ENSMUSG00000032369

Description: phospholipid scramblase 1

Associated with

Acute-phase response
(GO:0006953)
Calcium ion binding
(GO:0005509)
Cd4 receptor binding
(GO:0042609)
Cellular response to cytokine stimulus
(GO:0071345)
Cellular response to lipopolysaccharide
(GO:0071222)
Collagen-containing extracellular matrix
(GO:0062023)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna binding
(GO:0003677)
Enzyme binding
(GO:0019899)
Epidermal growth factor receptor binding
(GO:0005154)
Golgi apparatus
(GO:0005794)
Hydrolase activity
(GO:0016787)
Immune response
(GO:0006955)
Intrinsic apoptotic signaling pathway
(GO:0097193)
Lead ion binding
(GO:0032791)
Lipid transport
(GO:0006869)
Magnesium ion binding
(GO:0000287)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Mercury ion binding
(GO:0045340)
Myeloid cell differentiation
(GO:0030099)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of viral genome replication
(GO:0045071)
Nuclease activity
(GO:0004518)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphatidylserine biosynthetic process
(GO:0006659)
Phosphatidylserine exposure on apoptotic cell surface
(GO:0070782)
Phospholipid scramblase activity
(GO:0017128)
Plasma membrane
(GO:0005886)
Plasma membrane phospholipid scrambling
(GO:0017121)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of innate immune response
(GO:0045089)
Positive regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902231)
Protein binding
(GO:0005515)
Regulation of fc receptor mediated stimulatory signaling pathway
(GO:0060368)
Regulation of mast cell activation
(GO:0033003)
Response to interferon-alpha
(GO:0035455)
Sh3 domain binding
(GO:0017124)
Virus receptor activity
(GO:0001618)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Phospholipid scramblase 1

Genular Protein ID: 1859757194

Symbol: PLS1_MOUSE

Name: Phospholipid scramblase 1

UniProtKB Accession Codes:

Q9JJ00 O54730 O54731 Q9D1F8

Database IDs:

Citations:

PubMed ID: 10930526

Title: Identification of three new members of the phospholipid scramblase gene family.

PubMed ID: 10930526

DOI: 10.1016/s0005-2736(00)00236-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 9108418

Title: TRA1, a novel mRNA highly expressed in leukemogenic mouse monocytic sublines but not in nonleukemogenic sublines.

PubMed ID: 9108418

PubMed ID: 12010804

Title: Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1.

PubMed ID: 12010804

DOI: 10.1182/blood-2001-12-0271

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 26745724

Title: Phospholipid Scramblase 1 Modulates FcR-Mediated Phagocytosis in Differentiated Macrophages.

PubMed ID: 26745724

DOI: 10.1371/journal.pone.0145617

PubMed ID: 32110987

Title: Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis.

PubMed ID: 32110987

DOI: 10.3390/cells9030547

PubMed ID: 35595813

Title: ILDR1 promotes influenza A virus replication through binding to PLSCR1.

PubMed ID: 35595813

DOI: 10.1038/s41598-022-12598-3

Sequence Information:

Length: 328
Mass: 35914
Checksum: 6CA35DF8DBF72ACF
Sequence:

MENHSKQTEA PHPGTYMPAG YPPPYPPAAF QGPSDHAAYP IPQAGYQGPP GPYPGPQPGY 
PVPPGGYAGG GPSGFPVQNQ PAYNHPGGPG GTPWMPAPPP PLNCPPGLEY LAQIDQLLVH 
QQIELLEVLT GFETNNKYEI KNSLGQRVYF AVEDTDCCTR NCCGASRPFT LRILDNLGRE 
VMTLERPLRC SSCCFPCCLQ EIEIQAPPGV PVGYVTQTWH PCLPKFTLQN EKKQDVLKVV 
GPCVVCSCCS DIDFELKSLD EESVVGKISK QWSGFVREAF TDADNFGIQF PLDLDVKMKA 
VMLGACFLID FMFFERTGNE EQRSGAWQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Plscr1

Associated with

Other Information

Identification of three new members of the phospholipid scramblase gene family. PubMed ID: 10930526

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

TRA1, a novel mRNA highly expressed in leukemogenic mouse monocytic sublines but not in nonleukemogenic sublines. PubMed ID: 9108418

Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1. PubMed ID: 12010804

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Phospholipid Scramblase 1 Modulates FcR-Mediated Phagocytosis in Differentiated Macrophages. PubMed ID: 26745724

Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis. PubMed ID: 32110987

ILDR1 promotes influenza A virus replication through binding to PLSCR1. PubMed ID: 35595813