Genular: Defining Cellular Identity and Function

Details for: Trex1

Gene ID: 22040

Symbol: Trex1

Ensembl ID: ENSMUSG00000049734

Description: three prime repair exonuclease 1

Associated with

3'-5'-dna exonuclease activity
(GO:0008296)
3'-5' exonuclease activity
(GO:0008408)
Activation of immune response
(GO:0002253)
Adaptive immune response
(GO:0002250)
Adenyl deoxyribonucleotide binding
(GO:0032558)
Apoptotic cell clearance
(GO:0043277)
Atrial cardiac muscle tissue development
(GO:0003228)
Blood vessel development
(GO:0001568)
Cd86 biosynthetic process
(GO:0035781)
Cellular response to gamma radiation
(GO:0071480)
Cellular response to hydroxyurea
(GO:0072711)
Cellular response to interferon-beta
(GO:0035458)
Cellular response to organic substance
(GO:0071310)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to reactive oxygen species
(GO:0034614)
Cellular response to type i interferon
(GO:0071357)
Cellular response to uv
(GO:0034644)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Determination of adult lifespan
(GO:0008340)
Dna binding
(GO:0003677)
Dna binding, bending
(GO:0008301)
Dna catabolic process
(GO:0006308)
Dna damage checkpoint signaling
(GO:0000077)
Dna damage response
(GO:0006974)
Dna duplex unwinding
(GO:0032508)
Dna metabolic process
(GO:0006259)
Dna modification
(GO:0006304)
Dna replication
(GO:0006260)
Dna synthesis involved in uv-damage excision repair
(GO:1904161)
Double-stranded dna 3'-5' dna exonuclease activity
(GO:0008311)
Double-stranded dna binding
(GO:0003690)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Establishment of protein localization
(GO:0045184)
Exonuclease activity
(GO:0004527)
G2 phase
(GO:0051319)
Generation of precursor metabolites and energy
(GO:0006091)
Heart morphogenesis
(GO:0003007)
Heart process
(GO:0003015)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Immune complex formation
(GO:0097281)
Immune response
(GO:0006955)
Immune response in brain or nervous system
(GO:0002383)
Immunoglobulin production involved in immunoglobulin-mediated immune response
(GO:0002381)
Inflammatory response
(GO:0006954)
Inflammatory response to antigenic stimulus
(GO:0002437)
Innate immune response
(GO:0045087)
Interferon-alpha production
(GO:0032607)
Kidney development
(GO:0001822)
Lymphoid progenitor cell differentiation
(GO:0002320)
Macrophage activation involved in immune response
(GO:0002281)
Magnesium ion binding
(GO:0000287)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mitotic g1 dna damage checkpoint signaling
(GO:0031571)
Mutlalpha complex binding
(GO:0032405)
Mutsalpha complex binding
(GO:0032407)
Negative regulation of cgas/sting signaling pathway
(GO:0160049)
Negative regulation of innate immune response
(GO:0045824)
Negative regulation of type i interferon-mediated signaling pathway
(GO:0060339)
Nuclease activity
(GO:0004518)
Nucleic acid binding
(GO:0003676)
Nucleus
(GO:0005634)
Oligosaccharyltransferase complex
(GO:0008250)
Organ or tissue specific immune response
(GO:0002251)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein stabilization
(GO:0050821)
Regulation of catalytic activity
(GO:0050790)
Regulation of cellular metabolic process
(GO:0031323)
Regulation of cellular respiration
(GO:0043457)
Regulation of fatty acid metabolic process
(GO:0019217)
Regulation of gene expression
(GO:0010468)
Regulation of glycolytic process
(GO:0006110)
Regulation of immunoglobulin production
(GO:0002637)
Regulation of inflammatory response
(GO:0050727)
Regulation of innate immune response
(GO:0045088)
Regulation of lipid biosynthetic process
(GO:0046890)
Regulation of lysosome organization
(GO:1905671)
Regulation of protein complex stability
(GO:0061635)
Regulation of t cell activation
(GO:0050863)
Regulation of tumor necrosis factor production
(GO:0032680)
Regulation of type i interferon production
(GO:0032479)
Response to uv
(GO:0009411)
Retrotransposition
(GO:0032197)
Single-stranded dna binding
(GO:0003697)
T cell antigen processing and presentation
(GO:0002457)
Type i interferon-mediated signaling pathway
(GO:0060337)
Ww domain binding
(GO:0050699)

Other Information

Proteins

TREX1_MOUSE

Genular Protein ID: 654507681

Symbol: TREX1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q91XB0 Q3TAD7 Q9D6W2 Q9R1B0

Database IDs:

Citations:

PubMed ID: 10391904

Title: Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases.

PubMed ID: 10391904

DOI: 10.1074/jbc.274.28.19655

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11279105

Title: Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases. Characterization of the recombinant proteins.

PubMed ID: 11279105

DOI: 10.1074/jbc.m100623200

PubMed ID: 15254239

Title: Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA exonuclease develop inflammatory myocarditis.

PubMed ID: 15254239

DOI: 10.1128/mcb.24.15.6719-6727.2004

PubMed ID: 18045533

Title: Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease.

PubMed ID: 18045533

DOI: 10.1016/j.cell.2007.10.017

PubMed ID: 18724932

Title: Trex1 prevents cell-intrinsic initiation of autoimmunity.

PubMed ID: 18724932

DOI: 10.1016/j.cell.2008.06.032

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23993650

Title: Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing.

PubMed ID: 23993650

DOI: 10.1016/j.immuni.2013.08.004

PubMed ID: 24218451

Title: The exonuclease trex1 restrains macrophage proinflammatory activation.

PubMed ID: 24218451

DOI: 10.4049/jimmunol.1301603

PubMed ID: 17293595

Title: The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering.

PubMed ID: 17293595

DOI: 10.1074/jbc.m700039200

PubMed ID: 17355961

Title: Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains.

PubMed ID: 17355961

DOI: 10.1074/jbc.m700236200

PubMed ID: 18780819

Title: Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases.

PubMed ID: 18780819

DOI: 10.1110/ps.036426.108

PubMed ID: 22071149

Title: Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease.

PubMed ID: 22071149

DOI: 10.1016/j.dnarep.2011.10.007

PubMed ID: 33606975

Title: cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing.

PubMed ID: 33606975

DOI: 10.1016/j.molcel.2021.01.024

Sequence Information:

Length: 314
Mass: 33675
Checksum: 52C4F63A23214A7F
Sequence:

MGSQTLPHGH MQTLIFLDLE ATGLPSSRPE VTELCLLAVH RRALENTSIS QGHPPPVPRP 
PRVVDKLSLC IAPGKACSPG ASEITGLSKA ELEVQGRQRF DDNLAILLRA FLQRQPQPCC 
LVAHNGDRYD FPLLQTELAR LSTPSPLDGT FCVDSIAALK ALEQASSPSG NGSRKSYSLG 
SIYTRLYWQA PTDSHTAEGD VLTLLSICQW KPQALLQWVD EHARPFSTVK PMYGTPATTG 
TTNLRPHAAT ATTPLATANG SPSNGRSRRP KSPPPEKVPE APSQEGLLAP LSLLTLLTLA 
IATLYGLFLA SPGQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Trex1

Associated with

Other Information

Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'--&gt;5' exonucleases. PubMed ID: 10391904

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Excision of 3' termini by the Trex1 and TREX2 3'--&gt;5' exonucleases. Characterization of the recombinant proteins. PubMed ID: 11279105

Gene-targeted mice lacking the Trex1 (DNase III) 3'--&gt;5' DNA exonuclease develop inflammatory myocarditis. PubMed ID: 15254239

Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease. PubMed ID: 18045533

Trex1 prevents cell-intrinsic initiation of autoimmunity. PubMed ID: 18724932

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. PubMed ID: 23993650

The exonuclease trex1 restrains macrophage proinflammatory activation. PubMed ID: 24218451

The crystal structure of TREX1 explains the 3' nucleotide specificity and reveals a polyproline II helix for protein partnering. PubMed ID: 17293595

Structure of the dimeric exonuclease TREX1 in complex with DNA displays a proline-rich binding site for WW Domains. PubMed ID: 17355961

Structural and biochemical studies of TREX1 inhibition by metals. Identification of a new active histidine conserved in DEDDh exonucleases. PubMed ID: 18780819

Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease. PubMed ID: 22071149

cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing. PubMed ID: 33606975