Genular: Defining Cellular Identity and Function

Details for: Tfrc

Gene ID: 22042

Symbol: Tfrc

Ensembl ID: ENSMUSG00000022797

Description: transferrin receptor

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Golgi associated vesicle biogenesis
(R-MMU-432722)
Iron uptake and transport
(R-MMU-917937)
Membrane trafficking
(R-MMU-199991)
Rac1 gtpase cycle
(R-MMU-9013149)
Rac2 gtpase cycle
(R-MMU-9013404)
Rac3 gtpase cycle
(R-MMU-9013423)
Rhoa gtpase cycle
(R-MMU-8980692)
Rhob gtpase cycle
(R-MMU-9013026)
Rhoc gtpase cycle
(R-MMU-9013106)
Rhog gtpase cycle
(R-MMU-9013408)
Rho gtpase cycle
(R-MMU-9012999)
Rhoh gtpase cycle
(R-MMU-9013407)
Rhoq gtpase cycle
(R-MMU-9013406)
Rnd1 gtpase cycle
(R-MMU-9696273)
Rnd2 gtpase cycle
(R-MMU-9696270)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Trans-golgi network vesicle budding
(R-MMU-199992)
Transferrin endocytosis and recycling
(R-MMU-917977)
Transport of small molecules
(R-MMU-382551)
Vesicle-mediated transport
(R-MMU-5653656)
Basolateral plasma membrane
(GO:0016323)
Cell surface
(GO:0009986)
Cellular response to extracellular stimulus
(GO:0031668)
Cellular response to iron ion
(GO:0071281)
Cellular response to leukemia inhibitory factor
(GO:1990830)
Cellular response to xenobiotic stimulus
(GO:0071466)
Clathrin-coated pit
(GO:0005905)
Cytoplasmic vesicle
(GO:0031410)
Double-stranded rna binding
(GO:0003725)
Early endosome
(GO:0005769)
Endocytosis
(GO:0006897)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
External side of plasma membrane
(GO:0009897)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Hfe-transferrin receptor complex
(GO:1990712)
Hsp70 protein binding
(GO:0030544)
Identical protein binding
(GO:0042802)
Intracellular iron ion homeostasis
(GO:0006879)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular signal transduction
(GO:0035556)
Iron ion transmembrane transporter activity
(GO:0005381)
Iron ion transport
(GO:0006826)
Membrane
(GO:0016020)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of mitochondrial fusion
(GO:0010637)
Osteoclast differentiation
(GO:0030316)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of bone resorption
(GO:0045780)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of isotype switching
(GO:0045830)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of protein localization to nucleus
(GO:1900182)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of t cell proliferation
(GO:0042102)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Receptor internalization
(GO:0031623)
Recycling endosome
(GO:0055037)
Recycling endosome membrane
(GO:0055038)
Transferrin receptor activity
(GO:0004998)
Transferrin transport
(GO:0033572)

Other Information

Proteins

Transferrin receptor protein 1

Genular Protein ID: 2748748395

Symbol: TFR1_MOUSE

Name: Transferrin receptor protein 1

UniProtKB Accession Codes:

Q62351 Q61560

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2984291

Title: cDNA cloning of the murine transferrin receptor: sequence of trans-membrane and adjacent regions.

PubMed ID: 2984291

PubMed ID: 6092468

Title: The receptor for transferrin on murine myeloma cells: one-step purification based on its physiology, and partial amino acid sequence.

PubMed ID: 6092468

PubMed ID: 10192390

Title: Transferrin receptor is necessary for development of erythrocytes and the nervous system.

PubMed ID: 10192390

DOI: 10.1038/7727

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 26642240

Title: A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.

PubMed ID: 26642240

DOI: 10.1038/ng.3465

Sequence Information:

Length: 763
Mass: 85731
Checksum: 832A148CC26CE489
Sequence:

MMDQARSAFS NLFGGEPLSY TRFSLARQVD GDNSHVEMKL AADEEENADN NMKASVRKPK 
RFNGRLCFAA IALVIFFLIG FMSGYLGYCK RVEQKEECVK LAETEETDKS ETMETEDVPT 
SSRLYWADLK TLLSEKLNSI EFADTIKQLS QNTYTPREAG SQKDESLAYY IENQFHEFKF 
SKVWRDEHYV KIQVKSSIGQ NMVTIVQSNG NLDPVESPEG YVAFSKPTEV SGKLVHANFG 
TKKDFEELSY SVNGSLVIVR AGEITFAEKV ANAQSFNAIG VLIYMDKNKF PVVEADLALF 
GHAHLGTGDP YTPGFPSFNH TQFPPSQSSG LPNIPVQTIS RAAAEKLFGK MEGSCPARWN 
IDSSCKLELS QNQNVKLIVK NVLKERRILN IFGVIKGYEE PDRYVVVGAQ RDALGAGVAA 
KSSVGTGLLL KLAQVFSDMI SKDGFRPSRS IIFASWTAGD FGAVGATEWL EGYLSSLHLK 
AFTYINLDKV VLGTSNFKVS ASPLLYTLMG KIMQDVKHPV DGKSLYRDSN WISKVEKLSF 
DNAAYPFLAY SGIPAVSFCF CEDADYPYLG TRLDTYEALT QKVPQLNQMV RTAAEVAGQL 
IIKLTHDVEL NLDYEMYNSK LLSFMKDLNQ FKTDIRDMGL SLQWLYSARG DYFRATSRLT 
TDFHNAEKTN RFVMREINDR IMKVEYHFLS PYVSPRESPF RHIFWGSGSH TLSALVENLK 
LRQKNITAFN ETLFRNQLAL ATWTIQGVAN ALSGDIWNID NEF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tfrc

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

cDNA cloning of the murine transferrin receptor: sequence of trans-membrane and adjacent regions. PubMed ID: 2984291

The receptor for transferrin on murine myeloma cells: one-step purification based on its physiology, and partial amino acid sequence. PubMed ID: 6092468

Transferrin receptor is necessary for development of erythrocytes and the nervous system. PubMed ID: 10192390

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency. PubMed ID: 26642240