Details for: Tob1

Gene ID: 22057

Symbol: Tob1

Ensembl ID: ENSMUSG00000037573

Description: transducer of ErbB-2.1

Associated with

  • Ccr4-not complex
    (GO:0030014)
  • Cytoplasm
    (GO:0005737)
  • Negative regulation of bmp signaling pathway
    (GO:0030514)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of nuclear-transcribed mrna poly(a) tail shortening
    (GO:0060212)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Negative regulation of translation
    (GO:0017148)
  • Nucleus
    (GO:0005634)
  • Positive regulation of nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
    (GO:1900153)
  • Positive regulation of nuclear-transcribed mrna poly(a) tail shortening
    (GO:0060213)
  • Protein binding
    (GO:0005515)
  • Receptor tyrosine kinase binding
    (GO:0030971)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of smad protein signal transduction
    (GO:0060390)
  • Smad binding
    (GO:0046332)
  • Transcription corepressor activity
    (GO:0003714)

Other Information

Genular Protein ID: 3660802694

Symbol: TOB1_MOUSE

Name: Protein Tob1

UniProtKB Accession Codes:

Q61471 Q640M3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 1 GO 15 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9210596

Title: Cloning and characterization of the mouse tob gene.

PubMed ID: 9210596

DOI: 10.1016/s0378-1119(97)00049-8

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15235587

Title: Nuclear localization of Tob is important for regulation of its antiproliferative activity.

PubMed ID: 15235587

DOI: 10.1038/sj.onc.1207890

Sequence Information:

  • Length: 362
  • Mass: 40056
  • Checksum: 4D4F1F492A7CA6FC
  • Sequence:
    • MQLEIQVALN FIISYLYNKL PRRRVNIFGE ELERLLKKKY EGHWYPEKPY KGSGFRCIHV 
GEKVDPVIEQ ASKESGLDID DVRGNLPQDL SVWIDPFEVS YQIGEKGPVK VLYVDDSSET 
GCELDKEIKN SFNPEAQVFM PISDPASSVS SSPSPPFGHS AAVSPTFMPR STQPLTFTTA 
TFAATKFGST KMKNSGRSSK VARTSPINLG LTVNVNDLLK QKAISSSVHS LYGLGLGSQQ 
QPQPQPQQQQ QQQPSSSQPP PPLPQQQQQQ PQQQQQQQQQ TSALSPNAKE FIFPNMQGQG 
SSTNGMFPGD SPLNLSPLQY SNAFDVFAAY GGLNEKSFVD GLNFSLNNMQ YSNQQFQPVM 
AN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.