Details for: Trp53

Gene ID: 22059

Symbol: Trp53

Ensembl ID: ENSMUSG00000059552

Description: transformation related protein 53

Associated with

Other Information

Genular Protein ID: 1992106975

Symbol: P53_MOUSE

Name: Cellular tumor antigen p53

UniProtKB Accession Codes:

P02340 Q9QUP3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 22 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 100 Gene3D 3 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 8 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 3 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 22 RefSeq 3 SAM 1 SMR 1 STRING 1 SUPFAM 2 SwissPalm 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 6092064

Title: Analysis of the gene coding for the murine cellular tumour antigen p53.

PubMed ID: 6092064

DOI: 10.1002/j.1460-2075.1984.tb02110.x

PubMed ID: 6646235

Title: A single gene and a pseudogene for the cellular tumour antigen p53.

PubMed ID: 6646235

DOI: 10.1038/306594a0

PubMed ID: 6379601

Title: Cloning and expression analysis of full length mouse cDNA sequences encoding the transformation associated protein p53.

PubMed ID: 6379601

DOI: 10.1093/nar/12.14.5609

PubMed ID: 3023970

Title: Immunologically distinct p53 molecules generated by alternative splicing.

PubMed ID: 3023970

DOI: 10.1128/mcb.6.9.3232-3239.1986

PubMed ID: 3329909

Title: Primary structure of DNA complementary to mRNA of murine oncoprotein p53.

PubMed ID: 3329909

PubMed ID: 10403253

Title: DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage.

PubMed ID: 10403253

DOI: 10.1038/21913

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1766680

Title: Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice.

PubMed ID: 1766680

PubMed ID: 221923

Title: Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.

PubMed ID: 221923

DOI: 10.1073/pnas.76.5.2420

PubMed ID: 10644996

Title: p53 is involved in the p120E4F-mediated growth arrest.

PubMed ID: 10644996

DOI: 10.1038/sj.onc.1203250

PubMed ID: 12702766

Title: Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1).

PubMed ID: 12702766

DOI: 10.1073/pnas.0530308100

PubMed ID: 15526030

Title: Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.

PubMed ID: 15526030

DOI: 10.1038/sj.emboj.7600475

PubMed ID: 3006031

Title: Mapping of phosphomonoester and apparent phosphodiester bonds of the oncogene product p53 from simian virus 40-transformed 3T3 cells.

PubMed ID: 3006031

DOI: 10.1073/pnas.83.4.897

PubMed ID: 2145148

Title: The p53 tumour suppressor protein is phosphorylated at serine 389 by casein kinase II.

PubMed ID: 2145148

DOI: 10.1002/j.1460-2075.1990.tb07524.x

PubMed ID: 1406686

Title: p53 is covalently linked to 5.8S rRNA.

PubMed ID: 1406686

DOI: 10.1128/mcb.12.11.5145-5151.1992

PubMed ID: 11672522

Title: Negative control of p53 by Sir2alpha promotes cell survival under stress.

PubMed ID: 11672522

DOI: 10.1016/s0092-8674(01)00524-4

PubMed ID: 14719112

Title: Identification and characterization of murine mHAUSP encoding a deubiquitinating enzyme that regulates the status of p53 ubiquitination.

PubMed ID: 14719112

PubMed ID: 11706030

Title: Differential effect of ik3-1/cables on p53- and p73-induced cell death.

PubMed ID: 11706030

DOI: 10.1074/jbc.m108535200

PubMed ID: 12494467

Title: Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice.

PubMed ID: 12494467

DOI: 10.1002/ijc.10881

PubMed ID: 15195100

Title: PML regulates p53 stability by sequestering Mdm2 to the nucleolus.

PubMed ID: 15195100

DOI: 10.1038/ncb1147

PubMed ID: 17254968

Title: PRAK is essential for ras-induced senescence and tumor suppression.

PubMed ID: 17254968

DOI: 10.1016/j.cell.2006.11.050

PubMed ID: 17719541

Title: Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation.

PubMed ID: 17719541

DOI: 10.1016/j.cell.2007.06.013

PubMed ID: 18022393

Title: Novel homeodomain-interacting protein kinase family member, HIPK4, phosphorylates human p53 at serine 9.

PubMed ID: 18022393

DOI: 10.1016/j.febslet.2007.11.022

PubMed ID: 19151705

Title: CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis.

PubMed ID: 19151705

DOI: 10.1038/ncb1831

PubMed ID: 19556538

Title: Trim24 targets endogenous p53 for degradation.

PubMed ID: 19556538

DOI: 10.1073/pnas.0813177106

PubMed ID: 20673990

Title: A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response.

PubMed ID: 20673990

DOI: 10.1016/j.cell.2010.06.040

PubMed ID: 22726440

Title: p53 opens the mitochondrial permeability transition pore to trigger necrosis.

PubMed ID: 22726440

DOI: 10.1016/j.cell.2012.05.014

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 24051492

Title: p53 regulates Period2 expression and the circadian clock.

PubMed ID: 24051492

DOI: 10.1038/ncomms3444

PubMed ID: 24240685

Title: FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage.

PubMed ID: 24240685

DOI: 10.1038/onc.2013.494

PubMed ID: 25732823

Title: DBC1 functions as a tumor suppressor by regulating p53 stability.

PubMed ID: 25732823

DOI: 10.1016/j.celrep.2015.01.066

PubMed ID: 35122041

Title: Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways.

PubMed ID: 35122041

DOI: 10.1038/s43018-020-0086-7

PubMed ID: 11152481

Title: Crystal structure of the mouse p53 core DNA-binding domain at 2.7 A resolution.

PubMed ID: 11152481

DOI: 10.1074/jbc.m011644200

PubMed ID: 17139084

Title: High-resolution structure of the p53 core domain: implications for binding small-molecule stabilizing compounds.

PubMed ID: 17139084

DOI: 10.1107/s090744490603890x

PubMed ID: 16717092

Title: Structure of the p53 core domain dimer bound to DNA.

PubMed ID: 16717092

DOI: 10.1074/jbc.m603634200

PubMed ID: 17876829

Title: Crystal structure of the mouse p53 core domain in zinc-free state.

PubMed ID: 17876829

DOI: 10.1002/prot.21608

PubMed ID: 18978813

Title: Crystal structure of a p53 core tetramer bound to DNA.

PubMed ID: 18978813

DOI: 10.1038/onc.2008.400

Sequence Information:

  • Length: 390
  • Mass: 43458
  • Checksum: ED5A607378D921D7
  • Sequence:
    • MTAMEESQSD ISLELPLSQE TFSGLWKLLP PEDILPSPHC MDDLLLPQDV EEFFEGPSEA 
LRVSGAPAAQ DPVTETPGPV APAPATPWPL SSFVPSQKTY QGNYGFHLGF LQSGTAKSVM 
CTYSPPLNKL FCQLAKTCPV QLWVSATPPA GSRVRAMAIY KKSQHMTEVV RRCPHHERCS 
DGDGLAPPQH LIRVEGNLYP EYLEDRQTFR HSVVVPYEPP EAGSEYTTIH YKYMCNSSCM 
GGMNRRPILT IITLEDSSGN LLGRDSFEVR VCACPGRDRR TEEENFRKKE VLCPELPPGS 
AKRALPTCTS ASPPQKKKPL DGEYFTLKIR GRKRFEMFRE LNEALELKDA HATEESGDSR 
AHSSYLKTKK GQSTSRHKKT MVKKVGPDSD

Genular Protein ID: 1504394093

Symbol: Q80ZA1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q80ZA1

Database IDs:

AGR 1 ARBA 18 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 3 GeneTree 1 InterPro 7 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 6 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 1579500

Title: Alternatively spliced p53 RNA in transformed and normal cells of different tissue types.

PubMed ID: 1579500

DOI: 10.1093/nar/20.8.1979

PubMed ID: 7957051

Title: Wild-type alternatively spliced p53: binding to DNA and interaction with the major p53 protein in vitro and in cells.

PubMed ID: 7957051

PubMed ID: 8114705

Title: Endogenous p53 protein generated from wild-type alternatively spliced p53 RNA in mouse epidermal cells.

PubMed ID: 8114705

PubMed ID: 9060424

Title: DNA binding specificity of proteins derived from alternatively spliced mouse p53 mRNAs.

PubMed ID: 9060424

DOI: 10.1093/nar/25.7.1319

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

Sequence Information:

  • Length: 381
  • Mass: 42454
  • Checksum: 629AB65D5D38613B
  • Sequence:
    • MTAMEESQSD ISLELPLSQE TFSGLWKLLP PEDILPSPHC MDDLLLPQDV EEFFEGPSEA 
LRVSGAPAAQ DPVTETPGPV APAPATPWPL SSFVPSQKTY QGNYGFHLGF LQSGTAKSVM 
CTYSPPLNKL FCQLAKTCPV QLWVSATPPA GSRVRAMAIY KKSQHMTEVV RRCPHHERCS 
DGDGLAPPQH LIRVEGNLYP EYLEDRQTFR HSVVVPYEPP EAGSEYTTIH YKYMCNSSCM 
GGMNRRPILT IITLEDSSGN LLGRDSFEVR VCACPGRDRR TEEENFRKKE VLCPELPPGS 
AKRALPTCTS ASPPQKKKPL DGEYFTLKIR GRKRFEMFRE LNEALELKDA HATEESGDSR 
AHSSLQPRAF QALIKEESPN C

Genular Protein ID: 366603663

Symbol: Q3UGQ1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UGQ1

Database IDs:

AGR 1 ARBA 18 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EMBL 2 GO 13 Gene3D 3 Genevisible 1 InterPro 7 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 6 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 2 UCSC 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 357
  • Mass: 39787
  • Checksum: 8ED09B4E6C3B6FFB
  • Sequence:
    • MTAMEESQSD ISLELPLSQE TFSGLWKLLP PEDILPSPHC MDDLLLPQDV EEFFEGPSEA 
LRVSGAPAAQ DPVTETPGPV APAPATPWPL SSFVPSQKTY QGNYGFHLGF LQSGTAKSVM 
CTYSPPLNKL FCQLAKTCPV QLWVSATPPA GSRVRAMAIY KKSQHMTEVV RRCPHHERCS 
DGDGLAPPQH LIRVEGNLYP EYLEDRQTFR HSVVVPYEPP EAGSEYTTIH YKYMCNSSCM 
GGMNRRPILT IITLEDSSGN LLGRDSFEVR VCACPGRDRR TEEENFRKKE VLCPELPPGS 
AKRALPTCTS ASPPQKKKPL DGEYFTLKIR GRKRFEMFRE LNEALELKDA HATEESG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.