Details for: Trp63

Gene ID: 22061

Symbol: Trp63

Ensembl ID: ENSMUSG00000022510

Description: transformation related protein 63

Associated with

  • Gene expression (transcription)
    (R-MMU-74160)
  • Generic transcription pathway
    (R-MMU-212436)
  • Regulation of tp53 activity
    (R-MMU-5633007)
  • Regulation of tp53 activity through association with co-factors
    (R-MMU-6804759)
  • Rna polymerase ii transcription
    (R-MMU-73857)
  • Transcriptional regulation by tp53
    (R-MMU-3700989)
  • Anatomical structure formation involved in morphogenesis
    (GO:0048646)
  • Animal organ morphogenesis
    (GO:0009887)
  • Apoptotic process
    (GO:0006915)
  • Cellular senescence
    (GO:0090398)
  • Chromatin binding
    (GO:0003682)
  • Chromatin remodeling
    (GO:0006338)
  • Cloacal septation
    (GO:0060197)
  • Cranial skeletal system development
    (GO:1904888)
  • Damaged dna binding
    (GO:0003684)
  • Determination of adult lifespan
    (GO:0008340)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dna damage response
    (GO:0006974)
  • Double-stranded dna binding
    (GO:0003690)
  • Ectoderm and mesoderm interaction
    (GO:0007499)
  • Embryonic forelimb morphogenesis
    (GO:0035115)
  • Embryonic hindlimb morphogenesis
    (GO:0035116)
  • Embryonic limb morphogenesis
    (GO:0030326)
  • Epidermal cell differentiation
    (GO:0009913)
  • Epidermal cell division
    (GO:0010481)
  • Epidermis development
    (GO:0008544)
  • Epithelial cell development
    (GO:0002064)
  • Epithelial cell differentiation
    (GO:0030855)
  • Establishment of planar polarity
    (GO:0001736)
  • Establishment of skin barrier
    (GO:0061436)
  • Female genitalia morphogenesis
    (GO:0048807)
  • Hair follicle development
    (GO:0001942)
  • Hair follicle morphogenesis
    (GO:0031069)
  • Identical protein binding
    (GO:0042802)
  • Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
    (GO:0042771)
  • Keratinocyte differentiation
    (GO:0030216)
  • Keratinocyte proliferation
    (GO:0043616)
  • Mdm2/mdm4 family protein binding
    (GO:0097371)
  • Metal ion binding
    (GO:0046872)
  • Morphogenesis of a polarized epithelium
    (GO:0001738)
  • Multicellular organism development
    (GO:0007275)
  • Negative regulation of cellular senescence
    (GO:2000773)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of intracellular estrogen receptor signaling pathway
    (GO:0033147)
  • Negative regulation of keratinocyte differentiation
    (GO:0045617)
  • Negative regulation of mesoderm development
    (GO:2000381)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron apoptotic process
    (GO:0051402)
  • Notch signaling pathway
    (GO:0007219)
  • Odontogenesis of dentin-containing tooth
    (GO:0042475)
  • P53 binding
    (GO:0002039)
  • Pattern specification process
    (GO:0007389)
  • Polarized epithelial cell differentiation
    (GO:0030859)
  • Positive regulation of apoptotic signaling pathway
    (GO:2001235)
  • Positive regulation of cell cycle g1/s phase transition
    (GO:1902808)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of fibroblast apoptotic process
    (GO:2000271)
  • Positive regulation of keratinocyte proliferation
    (GO:0010838)
  • Positive regulation of notch signaling pathway
    (GO:0045747)
  • Positive regulation of osteoblast differentiation
    (GO:0045669)
  • Positive regulation of somatic stem cell population maintenance
    (GO:1904674)
  • Positive regulation of stem cell proliferation
    (GO:2000648)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Post-anal tail morphogenesis
    (GO:0036342)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Prostate gland development
    (GO:0030850)
  • Prostatic bud formation
    (GO:0060513)
  • Protein binding
    (GO:0005515)
  • Protein domain specific binding
    (GO:0019904)
  • Protein tetramerization
    (GO:0051262)
  • Proximal/distal pattern formation
    (GO:0009954)
  • Regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043281)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of epidermal cell division
    (GO:0010482)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Skeletal system development
    (GO:0001501)
  • Skin epidermis development
    (GO:0098773)
  • Skin morphogenesis
    (GO:0043589)
  • Squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
    (GO:0060529)
  • Stem cell differentiation
    (GO:0048863)
  • Stem cell proliferation
    (GO:0072089)
  • Sympathetic nervous system development
    (GO:0048485)
  • Transcription by rna polymerase ii
    (GO:0006366)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Ww domain binding
    (GO:0050699)

Other Information

Genular Protein ID: 3706893007

Symbol: P63_MOUSE

Name: Tumor protein 63

UniProtKB Accession Codes:

O88898 O88897 O88899 O89097 Q8C826 Q9QWY9 Q9QWZ0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 4 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 ELM 1 EMBL 14 Ensembl 4 ExpressionAtlas 1 GO 87 Gene3D 3 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 RNAct 1 Reactome 1 RefSeq 7 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 TreeFam 1 UCSC 6 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9774969

Title: p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.

PubMed ID: 9774969

DOI: 10.1016/s1097-2765(00)80275-0

PubMed ID: 9703973

Title: A second p53-related protein, p73L, with high homology to p73.

PubMed ID: 9703973

DOI: 10.1006/bbrc.1998.9013

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10227293

Title: p63 is a p53 homologue required for limb and epidermal morphogenesis.

PubMed ID: 10227293

DOI: 10.1038/19531

PubMed ID: 10227294

Title: p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development.

PubMed ID: 10227294

DOI: 10.1038/19539

PubMed ID: 11932750

Title: p63 and p73 are required for p53-dependent apoptosis in response to DNA damage.

PubMed ID: 11932750

DOI: 10.1038/416560a

PubMed ID: 14729569

Title: p63 is the molecular switch for initiation of an epithelial stratification program.

PubMed ID: 14729569

DOI: 10.1101/gad.1165104

PubMed ID: 18806757

Title: WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis.

PubMed ID: 18806757

DOI: 10.1038/cdd.2008.134

PubMed ID: 22197488

Title: Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus.

PubMed ID: 22197488

DOI: 10.1016/j.ajhg.2011.11.013

PubMed ID: 32758484

Title: Keratin 13 deficiency causes white sponge nevus in mice.

PubMed ID: 32758484

DOI: 10.1016/j.ydbio.2020.07.016

PubMed ID: 36856110

Title: TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis.

PubMed ID: 36856110

DOI: 10.1172/jci162315

Sequence Information:

  • Length: 680
  • Mass: 76789
  • Checksum: 8DFF0284F247C68A
  • Sequence:
    • MNFETSRCAT LQYCPDPYIQ RFIETPAHFS WKESYYRSAM SQSTQTSEFL SPEVFQHIWD 
FLEQPICSVQ PIELNFVDEP SENGATNKIE ISMDCIRMQD SDLSDPMWPQ YTNLGLLNSM 
DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS 
FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV 
VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT 
TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR 
KQQVSDSAKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL LYLPVRGRET YEMLLKIKES 
LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ TSMQSQSSYG NSSPPLNKMN SMNKLPSVSQ 
LINPQQRNAL TPTTMPEGMG ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP 
PPYPTDCSIV SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG 
ILDHRQLHDF SSPPHLLRTP SGASTVSVGS SETRGERVID AVRFTLRQTI SFPPRDEWND 
FNFDMDSRRN KQQRIKEEGE

Genular Protein ID: 2616579014

Symbol: Q569E5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q569E5

Database IDs:

AGR 1 ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 2 GeneTree 1 HOGENOM 1 InterPro 6 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 3 RuleBase 1 SAM 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 393
  • Mass: 44439
  • Checksum: D72C8DEF2384BD1E
  • Sequence:
    • MLYLENNAQT QFSEPQYTNL GLLNSMDQQI QNGSSSTSPY NTDHAQNSVT APSPYAQPSS 
TFDALSPSPA IPSNTDYPGP HSFDVSFQQS STAKSATWTY STELKKLYCQ IAKTCPIQIK 
VMTPPPQGAV IRAMPVYKKA EHVTEVVKRC PNHELSREFN EGQIAPPSHL IRVEGNSHAQ 
YVEDPITGRQ SVLVPYEPPQ VGTEFTTVLY NFMCNSSCVG GMNRRPILII VTLETRDGQV 
LGRRCFEARI CACPGRDRKA DEDSIRKQQV SDSAKNGDGT KRPFRQNTHG IQMTSIKKRR 
SPDDELLYLP VRGRETYEML LKIKESLELM QYLPQHTIET YRQQQQQQHQ HLLQKHLLSA 
CFRNELVEPR GEAPTQSDVF FRHSNPPNHS VYP

Genular Protein ID: 2866243720

Symbol: Q5CZX0_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q5CZX0

Database IDs:

AGR 1 ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EMBL 2 GO 9 Gene3D 3 Genevisible 1 InterPro 9 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 3 RefSeq 5 RuleBase 1 SAM 1 SMART 2 SUPFAM 3

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 582
  • Mass: 65329
  • Checksum: AF8D05E3249406D1
  • Sequence:
    • MLYLENNAQT QFSEPQYTNL GLLNSMDQQI QNGSSSTSPY NTDHAQNSVT APSPYAQPSS 
TFDALSPSPA IPSNTDYPGP HSFDVSFQQS STAKSATWTY STELKKLYCQ IAKTCPIQIK 
VMTPPPQGAV IRAMPVYKKA EHVTEVVKRC PNHELSREFN EGQIAPPSHL IRVEGNSHAQ 
YVEDPITGRQ SVLVPYEPPQ VGTEFTTVLY NFMCNSSCVG GMNRRPILII VTLETRDGQV 
LGRRCFEARI CACPGRDRKA DEDSIRKQQV SDSAKNGDAF RQNTHGIQMT SIKKRRSPDD 
ELLYLPVRGR ETYEMLLKIK ESLELMQYLP QHTIETYRQQ QQQQHQHLLQ KQTSMQSQSS 
YGNSSPPLNK MNSMNKLPSV SQLINPQQRN ALTPTTMPEG MGANIPMMGT HMPMPGDMNG 
LSPTQALPPP LSMPSTSHCT PPPPYPTDCS IVSFLARLGC SSCLDYFTTQ GLTTIYQIEH 
YSIDDLASLK IPEQFRHAIW KGILDHRQLH DFSSPPHLLR TPSGASTVSV GSSETRGERV 
IDAVRFTLRQ TISFPPRDEW NDFNFDMDSR RNKQQRIKEE GE

Genular Protein ID: 111180456

Symbol: Q3UVI3_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UVI3

Database IDs:

AGR 1 ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 3 GeneTree 1 HOGENOM 1 InterPro 9 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 582
  • Mass: 65321
  • Checksum: 0BD0FA81CB46EFA0
  • Sequence:
    • MLYLENNAQT QFSEPQYTNL GLLNSMDQQI QNGSSSTSPY NTDHAQNSVT APSPYAQPSS 
TFDALSPSPA IPSNTDYPGP HSFDVSFQQS STAKSATWTY STELKKLYCQ IAKTCPIQIK 
VMTPPPQGAV IRAMPVYKKA EHVTEVVKRC PNHELSREFN EGQIAPPSHL IRVEGNSHAQ 
YVEDPITGRQ SVLVPYEPPQ VGTEFTTVLY NFMCNSSCVG GMNRRPILII VTLETRDGQV 
LGRRCFEARI CACPGRDRKA DEDSIRKQQV SDSAKNGDAF RQNTHGIQMT SIKKRRSPDD 
ELLYLPVRGR ETYEMLLKIK ESLELMQYLP QHTIETYRQQ QQQQHQHLLQ KQTSMQSQSS 
YGNSSPPLNK MNSMNKLPSV SQLINPQQRN ALTPTTMPEG MGANIPMMGT HMPMAGDMNG 
LSPTQALPPP LSMPSTSHCT PPPPYPTDCS IVSFLARLGC SSCLDYFTTQ GLTTIYQIEH 
YSMDDLASLK IPEQFRHAIW KGILDHRQLH DFSSPPHLLR TPSGASTVSV GSSETRGERV 
IDAVRFTLRQ TISFPPRDEW NDFNFDMDSR RNKQQRIKEE GE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.