Genular: Defining Cellular Identity and Function

Details for: Tsg101

Gene ID: 22088

Symbol: Tsg101

Ensembl ID: ENSMUSG00000014402

Description: tumor susceptibility gene 101

Associated with

Endosomal sorting complex required for transport (escrt)
(R-MMU-917729)
Membrane trafficking
(R-MMU-199991)
Vesicle-mediated transport
(R-MMU-5653656)
Calcium-dependent protein binding
(GO:0048306)
Cell cycle
(GO:0007049)
Cell differentiation
(GO:0030154)
Cell division
(GO:0051301)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Early endosome
(GO:0005769)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Endosome to lysosome transport
(GO:0008333)
Escrt i complex
(GO:0000813)
Exosomal secretion
(GO:1990182)
Extracellular exosome
(GO:0070062)
Extracellular transport
(GO:0006858)
Keratinocyte differentiation
(GO:0030216)
Late endosome
(GO:0005770)
Membrane
(GO:0016020)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epidermal growth factor-activated receptor activity
(GO:0007175)
Negative regulation of epidermal growth factor receptor signaling pathway
(GO:0042059)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear receptor coactivator activity
(GO:0030374)
Nucleolus
(GO:0005730)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of exosomal secretion
(GO:1903543)
Positive regulation of ubiquitin-dependent endocytosis
(GO:2000397)
Positive regulation of viral budding via host escrt complex
(GO:1903774)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein modification process
(GO:0036211)
Protein monoubiquitination
(GO:0006513)
Protein transport
(GO:0015031)
Regulation of cell cycle
(GO:0051726)
Regulation of cell growth
(GO:0001558)
Regulation of extracellular exosome assembly
(GO:1903551)
Regulation of map kinase activity
(GO:0043405)
Transcription corepressor activity
(GO:0003714)
Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
(GO:0043162)
Ubiquitin binding
(GO:0043130)
Ubiquitin protein ligase binding
(GO:0031625)
Viral budding
(GO:0046755)
Viral release from host cell
(GO:0019076)
Virion binding
(GO:0046790)

Other Information

Proteins

Tumor susceptibility gene 101 protein

Genular Protein ID: 4267348878

Symbol: TS101_MOUSE

Name: Tumor susceptibility gene 101 protein

UniProtKB Accession Codes:

Q61187

Database IDs:

Citations:

PubMed ID: 8616888

Title: Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells.

PubMed ID: 8616888

DOI: 10.1016/s0092-8674(00)81111-3

PubMed ID: 9840940

Title: Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: common types of shorter transcripts are true alternative splice variants.

PubMed ID: 9840940

DOI: 10.1038/sj.onc.1202529

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10888872

Title: DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.

PubMed ID: 10888872

DOI: 10.1038/77023

PubMed ID: 12927808

Title: Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less.

PubMed ID: 12927808

DOI: 10.1016/s0006-291x(03)01497-9

PubMed ID: 12802020

Title: TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation.

PubMed ID: 12802020

DOI: 10.1073/pnas.0932599100

PubMed ID: 15908698

Title: Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding.

PubMed ID: 15908698

DOI: 10.1074/jbc.m413735200

PubMed ID: 19703557

Title: Abnormal regulation of TSG101 in mice with spongiform neurodegeneration.

PubMed ID: 19703557

DOI: 10.1016/j.bbadis.2009.08.009

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 391
Mass: 44124
Checksum: 79558EC535093492
Sequence:

MAVSESQLKK MMSKYKYRDL TVRQTVNVIA MYKDLKPVLD SYVFNDGSSR ELVNLTGTIP 
VRYRGNIYNI PICLWLLDTY PYNPPICFVK PTSSMTIKTG KHVDANGKIY LPYLHDWKHP 
RSELLELIQI MIVIFGEEPP VFSRPTVSAS YPPYTATGPP NTSYMPGMPS GISAYPSGYP 
PNPSGYPGCP YPPAGPYPAT TSSQYPSQPP VTTVGPSRDG TISEDTIRAS LISAVSDKLR 
WRMKEEMDGA QAELNALKRT EEDLKKGHQK LEEMVTRLDQ EVAEVDKNIE LLKKKDEELS 
SALEKMENQS ENNDIDEVII PTAPLYKQIL NLYAEENAIE DTIFYLGEAL RRGVIDLDVF 
LKHVRLLSRK QFQLRALMQK ARKTAGLSDL Y

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tsg101

Associated with

Other Information

Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells. PubMed ID: 8616888

Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: common types of shorter transcripts are true alternative splice variants. PubMed ID: 9840940

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. PubMed ID: 10888872

Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less. PubMed ID: 12927808

TSG101 interaction with HRS mediates endosomal trafficking and receptor down-regulation. PubMed ID: 12802020

Tsg101 and Alix interact with murine leukemia virus Gag and cooperate with Nedd4 ubiquitin ligases during budding. PubMed ID: 15908698

Abnormal regulation of TSG101 in mice with spongiform neurodegeneration. PubMed ID: 19703557

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079