Details for: ALDH3B1

Gene ID: 221

Symbol: ALDH3B1

Ensembl ID: ENSG00000006534

Description: aldehyde dehydrogenase 3 family member B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 72.8406
    Cell Significance Index: -11.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 43.9594
    Cell Significance Index: -11.1500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 22.2790
    Cell Significance Index: -11.4600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 17.6000
    Cell Significance Index: -11.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.5543
    Cell Significance Index: -11.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0385
    Cell Significance Index: -11.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.4853
    Cell Significance Index: 282.6700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1936
    Cell Significance Index: 22.0600
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.0804
    Cell Significance Index: 2.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9625
    Cell Significance Index: 57.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.9458
    Cell Significance Index: -2.0700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8612
    Cell Significance Index: 11.7500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5777
    Cell Significance Index: 62.8400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.5728
    Cell Significance Index: 3.8000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5100
    Cell Significance Index: 59.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4997
    Cell Significance Index: 451.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4020
    Cell Significance Index: 8.7100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3281
    Cell Significance Index: 22.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3141
    Cell Significance Index: 51.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2925
    Cell Significance Index: 7.8300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.2908
    Cell Significance Index: 3.0000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.2903
    Cell Significance Index: 2.8400
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.2363
    Cell Significance Index: 2.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2327
    Cell Significance Index: 15.0100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.2048
    Cell Significance Index: 1.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1659
    Cell Significance Index: 90.6000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1625
    Cell Significance Index: 16.0700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1554
    Cell Significance Index: 19.9200
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.1546
    Cell Significance Index: 1.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1519
    Cell Significance Index: 94.8700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1423
    Cell Significance Index: 1.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0909
    Cell Significance Index: 4.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0674
    Cell Significance Index: 3.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0312
    Cell Significance Index: 3.8400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0083
    Cell Significance Index: 1.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0070
    Cell Significance Index: 0.8000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0060
    Cell Significance Index: 0.0900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0059
    Cell Significance Index: 4.4600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0056
    Cell Significance Index: 0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0048
    Cell Significance Index: 9.1100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0046
    Cell Significance Index: 0.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0009
    Cell Significance Index: -0.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0016
    Cell Significance Index: -0.1000
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0035
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0042
    Cell Significance Index: -2.6700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0050
    Cell Significance Index: -0.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0074
    Cell Significance Index: -13.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0084
    Cell Significance Index: -6.2000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0090
    Cell Significance Index: -0.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0099
    Cell Significance Index: -15.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0110
    Cell Significance Index: -2.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0116
    Cell Significance Index: -15.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0117
    Cell Significance Index: -1.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0118
    Cell Significance Index: -6.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0118
    Cell Significance Index: -2.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0140
    Cell Significance Index: -10.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0158
    Cell Significance Index: -0.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0191
    Cell Significance Index: -5.5100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0200
    Cell Significance Index: -8.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0233
    Cell Significance Index: -8.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0238
    Cell Significance Index: -10.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0315
    Cell Significance Index: -6.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0340
    Cell Significance Index: -0.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0355
    Cell Significance Index: -7.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0446
    Cell Significance Index: -6.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0522
    Cell Significance Index: -5.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0744
    Cell Significance Index: -2.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0789
    Cell Significance Index: -10.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0813
    Cell Significance Index: -3.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0866
    Cell Significance Index: -5.4600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0934
    Cell Significance Index: -3.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0971
    Cell Significance Index: -11.4600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0994
    Cell Significance Index: -1.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1094
    Cell Significance Index: -11.3900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1247
    Cell Significance Index: -9.8800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1264
    Cell Significance Index: -8.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1274
    Cell Significance Index: -9.7800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1313
    Cell Significance Index: -9.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1364
    Cell Significance Index: -4.3700
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.1561
    Cell Significance Index: -1.6900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1753
    Cell Significance Index: -1.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1881
    Cell Significance Index: -12.6500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1973
    Cell Significance Index: -5.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2001
    Cell Significance Index: -9.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2073
    Cell Significance Index: -12.7400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2220
    Cell Significance Index: -12.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2420
    Cell Significance Index: -12.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2776
    Cell Significance Index: -10.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2856
    Cell Significance Index: -7.3400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.2878
    Cell Significance Index: -2.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2910
    Cell Significance Index: -12.8700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3002
    Cell Significance Index: -3.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3047
    Cell Significance Index: -7.0400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3050
    Cell Significance Index: -4.5700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3110
    Cell Significance Index: -10.9000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3147
    Cell Significance Index: -4.5100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3164
    Cell Significance Index: -5.0200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3186
    Cell Significance Index: -11.0700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.3210
    Cell Significance Index: -4.6600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3215
    Cell Significance Index: -13.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** ALDH3B1 catalyzes the conversion of aldehydes to their corresponding carboxylic acids, a process essential for removing toxic aldehydes from the cell. 2. **Cellular Expression:** ALDH3B1 is highly expressed in ciliated columnar cells of the tracheobronchial tree, as well as in immune cells, such as immature innate lymphoid cells. 3. **Metabolic Pathways:** The ALDH3B1 enzyme participates in multiple metabolic pathways, including alcohol metabolism, aldehyde catabolism, and sphingolipid metabolism. 4. **Antioxidant Properties:** ALDH3B1 has been shown to possess antioxidant properties, protecting cells from oxidative stress and damage. **Pathways and Functions:** 1. **Aldehyde Catabolism:** ALDH3B1 plays a crucial role in the catabolism of aldehydes, converting them into their corresponding carboxylic acids. 2. **Alcohol Metabolism:** The enzyme is involved in the metabolism of alcohols, facilitating the conversion of alcohols into their corresponding carboxylic acids. 3. **Sphingolipid Metabolism:** ALDH3B1 participates in the catabolism of sphingolipids, a process essential for maintaining cellular membrane structure and function. 4. **Immune System Regulation:** The enzyme has been implicated in the regulation of immune responses, particularly in the context of innate immunity. **Clinical Significance:** 1. **Cancer:** Dysregulation of ALDH3B1 has been linked to various cancers, including lung, breast, and colon cancer. 2. **Neurological Disorders:** ALDH3B1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Inflammatory Conditions:** The enzyme has been shown to play a role in the regulation of inflammatory responses, particularly in the context of innate immunity. 4. **Toxicity:** ALDH3B1 has been implicated in the detoxification of toxic compounds, including alcohols and aldehydes. In conclusion, ALDH3B1 is a multifaceted enzyme that plays a critical role in maintaining cellular homeostasis and regulating immune responses. Its dysregulation has been linked to various diseases, highlighting the importance of this enzyme in human health and disease. Further research is necessary to fully elucidate the mechanisms by which ALDH3B1 regulates cellular metabolism and immune responses.

Genular Protein ID: 977941216

Symbol: AL3B1_HUMAN

Name: Aldehyde dehydrogenase family 3 member B1

UniProtKB Accession Codes:

P43353 A3FMP9 Q53XL5 Q8N515 Q96CK8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 67 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 4 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 20 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 11 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7828891

Title: Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family.

PubMed ID: 7828891

DOI: 10.1016/0378-1119(94)90672-6

PubMed ID: 17382292

Title: Expression and initial characterization of human ALDH3B1.

PubMed ID: 17382292

DOI: 10.1016/j.bbrc.2007.03.046

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23721920

Title: Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1.

PubMed ID: 23721920

DOI: 10.1016/j.bbalip.2013.05.007

Sequence Information:

  • Length: 468
  • Mass: 51840
  • Checksum: 30BEEB982395D2F7
  • Sequence:
    • MDPLGDTLRR LREAFHAGRT RPAEFRAAQL QGLGRFLQEN KQLLHDALAQ DLHKSAFESE 
VSEVAISQGE VTLALRNLRA WMKDERVPKN LATQLDSAFI RKEPFGLVLI IAPWNYPLNL 
TLVPLVGALA AGNCVVLKPS EISKNVEKIL AEVLPQYVDQ SCFAVVLGGP QETGQLLEHR 
FDYIFFTGSP RVGKIVMTAA AKHLTPVTLE LGGKNPCYVD DNCDPQTVAN RVAWFRYFNA 
GQTCVAPDYV LCSPEMQERL LPALQSTITR FYGDDPQSSP NLGRIINQKQ FQRLRALLGC 
GRVAIGGQSD ESDRYIAPTV LVDVQEMEPV MQEEIFGPIL PIVNVQSLDE AIEFINRREK 
PLALYAFSNS SQVVKRVLTQ TSSGGFCGND GFMHMTLASL PFGGVGASGM GRYHGKFSFD 
TFSHHRACLL RSPGMEKLNA LRYPPQSPRR LRMLLVAMEA QGCSCTLL

Genular Protein ID: 3652505263

Symbol: A0A087X2D4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X2D4

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 HGNC 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 351
  • Mass: 38881
  • Checksum: EE2D63858DA70607
  • Sequence:
    • MDPLGDTLRR LREAFHAGRT RPAEFRAAQL QGLGRFLQEN KQLLHDALAQ DLHKSAFESE 
VSEVAISQGE VTLALRNLRA WMKDERVPKN LATQLDSAFI RKEPFGLVLI IAPWNYPLNL 
TLVPLVGALA AGNCVVLKPS EISKNVEKIL AEVLPQYVDQ SSPNLGRIIN QKQFQRLRAL 
LGCGRVAIGG QSDESDRYIA PTVLVDVQEM EPVMQEEIFG PILPIVNVQS LDEAIEFINR 
REKPLALYAF SNSSQVVKRV LTQTSSGGFC GNDGFMHMTL ASLPFGGVGA SGMGRYHGKF 
SFDTFSHHRA CLLRSPGMEK LNALRYPPQS PRRLRMLLVA MEAQGCSCTL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.