Details for: ALDH3B1

Gene ID: 221

Symbol: ALDH3B1

Ensembl ID: ENSG00000006534

Description: aldehyde dehydrogenase 3 family member B1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.74
    Marker Score: 23784
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.47
    Marker Score: 8480
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.81
    Marker Score: 1357
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.76
    Marker Score: 3348.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.74
    Marker Score: 2102
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.63
    Marker Score: 1092
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.3
    Marker Score: 617
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.29
    Marker Score: 2631
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.23
    Marker Score: 2905
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.18
    Marker Score: 538
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.14
    Marker Score: 2163
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.12
    Marker Score: 2180
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.06
    Marker Score: 59222
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 788
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.02
    Marker Score: 693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71802
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48027
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.95
    Marker Score: 446
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.95
    Marker Score: 2468
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5285
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2734
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.88
    Marker Score: 254
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.88
    Marker Score: 2115
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5281
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.84
    Marker Score: 2096
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.83
    Marker Score: 13043
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.82
    Marker Score: 561
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.79
    Marker Score: 353
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 311
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.76
    Marker Score: 244
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3150.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.74
    Marker Score: 4811
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.73
    Marker Score: 3852
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 657
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.71
    Marker Score: 18187
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.7
    Marker Score: 176
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.7
    Marker Score: 708
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.69
    Marker Score: 4386
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 449
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.68
    Marker Score: 10893
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.67
    Marker Score: 213
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.64
    Marker Score: 1177
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.64
    Marker Score: 306
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.62
    Marker Score: 339
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.61
    Marker Score: 696
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.61
    Marker Score: 300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.59
    Marker Score: 403
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.58
    Marker Score: 530
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.56
    Marker Score: 450
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.56
    Marker Score: 194
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.55
    Marker Score: 881
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.54
    Marker Score: 542
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.54
    Marker Score: 6271
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.53
    Marker Score: 319
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.52
    Marker Score: 606
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.51
    Marker Score: 3120
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.51
    Marker Score: 129
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.5
    Marker Score: 1783
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.47
    Marker Score: 751
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.47
    Marker Score: 449
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.46
    Marker Score: 2218
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.45
    Marker Score: 288
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.45
    Marker Score: 1936
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.44
    Marker Score: 999
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.43
    Marker Score: 1795
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.43
    Marker Score: 260
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.41
    Marker Score: 204
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4
    Marker Score: 4026
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.39
    Marker Score: 388
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.39
    Marker Score: 621
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.39
    Marker Score: 326
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.38
    Marker Score: 131
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.36
    Marker Score: 144
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.36
    Marker Score: 93
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.36
    Marker Score: 158
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.35
    Marker Score: 86
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.35
    Marker Score: 175
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.35
    Marker Score: 542
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 89
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.33
    Marker Score: 208
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.33
    Marker Score: 104
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.33
    Marker Score: 155
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.32
    Marker Score: 139
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.32
    Marker Score: 351
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.31
    Marker Score: 10908
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.31
    Marker Score: 327
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.31
    Marker Score: 88
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.31
    Marker Score: 164
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3
    Marker Score: 75
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.3
    Marker Score: 111

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Other Information

**Key characteristics:** * ALDH3B1 is a glycoprotein with a molecular weight of approximately 500 kDa. * It is a member of the aldehyde dehydrogenase (NAD+) superfamily. * It is expressed in high levels in the liver and kidney. **Pathways and functions:** * ALDH3B1 is involved in the metabolism of aldehydes through the following pathways: * The 3-chloroallyl aldehyde dehydrogenase activity * The alcohol metabolic process * The aldehyde dehydrogenase (NAD+) activity * The aldehyde dehydrogenase [nad(p)+] activity * The benzaldehyde dehydrogenase (NAD+) activity * The benzaldehyde dehydrogenase (nadp+) activity * It also plays a role in the cellular aldehyde metabolic process, the sphingolipid catabolism, and the sphingolipid metabolic process. **Clinical significance:** * Mutations in ALDH3B1 have been linked to several diseases, including liver disease, kidney disease, and cancer. * ALDH3B1 inhibitors are being investigated as potential treatments for these diseases. **Additional information:** * ALDH3B1 is a highly conserved protein, with similar sequences found in organisms from different species. * It is a regulated protein, and its expression is influenced by a variety of factors, including nutrients, hormones, and cytokines.

Genular Protein ID: 977941216

Symbol: AL3B1_HUMAN

Name: Aldehyde dehydrogenase family 3 member B1

UniProtKB Accession Codes:

P43353 A3FMP9 Q53XL5 Q8N515 Q96CK8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 67 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 4 EMBL 8 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 20 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 11 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7828891

Title: Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family.

PubMed ID: 7828891

DOI: 10.1016/0378-1119(94)90672-6

PubMed ID: 17382292

Title: Expression and initial characterization of human ALDH3B1.

PubMed ID: 17382292

DOI: 10.1016/j.bbrc.2007.03.046

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23721920

Title: Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1.

PubMed ID: 23721920

DOI: 10.1016/j.bbalip.2013.05.007

Sequence Information:

  • Length: 468
  • Mass: 51840
  • Checksum: 30BEEB982395D2F7
  • Sequence:
    • MDPLGDTLRR LREAFHAGRT RPAEFRAAQL QGLGRFLQEN KQLLHDALAQ DLHKSAFESE 
VSEVAISQGE VTLALRNLRA WMKDERVPKN LATQLDSAFI RKEPFGLVLI IAPWNYPLNL 
TLVPLVGALA AGNCVVLKPS EISKNVEKIL AEVLPQYVDQ SCFAVVLGGP QETGQLLEHR 
FDYIFFTGSP RVGKIVMTAA AKHLTPVTLE LGGKNPCYVD DNCDPQTVAN RVAWFRYFNA 
GQTCVAPDYV LCSPEMQERL LPALQSTITR FYGDDPQSSP NLGRIINQKQ FQRLRALLGC 
GRVAIGGQSD ESDRYIAPTV LVDVQEMEPV MQEEIFGPIL PIVNVQSLDE AIEFINRREK 
PLALYAFSNS SQVVKRVLTQ TSSGGFCGND GFMHMTLASL PFGGVGASGM GRYHGKFSFD 
TFSHHRACLL RSPGMEKLNA LRYPPQSPRR LRMLLVAMEA QGCSCTLL

Genular Protein ID: 3652505263

Symbol: A0A087X2D4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X2D4

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 EMBL 4 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 RefSeq 1 Rhea 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 351
  • Mass: 38881
  • Checksum: EE2D63858DA70607
  • Sequence:
    • MDPLGDTLRR LREAFHAGRT RPAEFRAAQL QGLGRFLQEN KQLLHDALAQ DLHKSAFESE 
VSEVAISQGE VTLALRNLRA WMKDERVPKN LATQLDSAFI RKEPFGLVLI IAPWNYPLNL 
TLVPLVGALA AGNCVVLKPS EISKNVEKIL AEVLPQYVDQ SSPNLGRIIN QKQFQRLRAL 
LGCGRVAIGG QSDESDRYIA PTVLVDVQEM EPVMQEEIFG PILPIVNVQS LDEAIEFINR 
REKPLALYAF SNSSQVVKRV LTQTSSGGFC GNDGFMHMTL ASLPFGGVGA SGMGRYHGKF 
SFDTFSHHRA CLLRSPGMEK LNALRYPPQS PRRLRMLLVA MEAQGCSCTL L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.