Genular: Defining Cellular Identity and Function

Details for: Ttf1

Gene ID: 22130

Symbol: Ttf1

Ensembl ID: ENSMUSG00000026803

Description: transcription termination factor, RNA polymerase I

Associated with

Gene expression (transcription)
(R-MMU-74160)
Metabolism of proteins
(R-MMU-392499)
Rna polymerase i promoter clearance
(R-MMU-73854)
Rna polymerase i transcription
(R-MMU-73864)
Rna polymerase i transcription initiation
(R-MMU-73762)
Rna polymerase i transcription termination
(R-MMU-73863)
Surfactant metabolism
(R-MMU-5683826)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Dna-templated transcription termination
(GO:0006353)
Dna binding
(GO:0003677)
Fibrillar center
(GO:0001650)
Negative regulation of dna replication
(GO:0008156)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Termination of rna polymerase i transcription
(GO:0006363)
Transcription by rna polymerase i
(GO:0006360)
Transcription initiation at rna polymerase i promoter
(GO:0006361)

Other Information

Proteins

Transcription termination factor 1
Q3TQG6_MOUSE

Genular Protein ID: 4157970688

Symbol: TTF1_MOUSE

Name: Transcription termination factor 1

UniProtKB Accession Codes:

Q62187 Q9JKK5

Database IDs:

Citations:

PubMed ID: 7720715

Title: Different domains of the murine RNA polymerase I-specific termination factor mTTF-I serve distinct functions in transcription termination.

PubMed ID: 7720715

DOI: 10.1002/j.1460-2075.1995.tb07108.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9092622

Title: Oligomerization of the transcription termination factor TTF-I: implications for the structural organization of ribosomal transcription units.

PubMed ID: 9092622

DOI: 10.1093/nar/25.6.1142

PubMed ID: 9267035

Title: Termination of mammalian rDNA replication: polar arrest of replication fork movement by transcription termination factor TTF-I.

PubMed ID: 9267035

DOI: 10.1016/s0092-8674(00)80515-2

PubMed ID: 9049305

Title: RNA polymerase I transcription on nucleosomal templates: the transcription termination factor TTF-I induces chromatin remodeling and relieves transcriptional repression.

PubMed ID: 9049305

DOI: 10.1093/emboj/16.4.760

PubMed ID: 9582279

Title: Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes.

PubMed ID: 9582279

DOI: 10.1093/emboj/17.10.2855

PubMed ID: 15292447

Title: The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo.

PubMed ID: 15292447

DOI: 10.1093/nar/gkh732

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20513429

Title: The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I.

PubMed ID: 20513429

DOI: 10.1016/j.molcel.2010.03.015

PubMed ID: 27528195

Title: PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges.

PubMed ID: 27528195

DOI: 10.7554/elife.17508

Sequence Information:

Length: 859
Mass: 97723
Checksum: D47950ECB3A08DCD
Sequence:

MKGGTSKFKT HTETLYKKKK WSSVSEKRPQ KCPSQCLESK QPQVSVLGKR RRASQTPAQE 
TLESEWPQKA KRKKRRREPQ TPAQETLESE WPQKAKKKKR RGEPQTPTQE SLESEQPPVS 
LLGKRRRESQ TPAQENSESE QPRKAKRRRK KRKGSQQPTS SLLKTPETFL KAKKTTSAHK 
KKKNSVLEVD METGIILVDK ENMENLLETS RKDVDIVYVD MSKGQRSAKV RETGELPAAK 
PQEHGCRELL GDVRSRKKQK HLQKVAPWDV VQGSQPESIS LPPSEPLSSE DLEGKSTEAA 
VFCKKKSKKN VFRSQELEPI PDSLDDSETI SERLDSTHHG GAVGAGEECE STKESHSIKK 
KSKKKKHKSV ALATSSDSAS VTDSKAKNAL VDSSEGSGAV REEDVDHRPA EAEAQACSTE 
KHREAMQRLE PTHEEESNSE SASNSAARHI SEDRRESDDS DVDLGSAVRQ LREFIPDIQE 
RAATTIRRMY RDDLGRFKEF KAQGVAIRFG KFSAKENKQI EKNVQDFLSL TGIESADKLL 
YTDRYPEEKT LITNLKRKHA FRLHIGKGIA RPWKLVYYRA KKIFDVNNYK GRYNEEDTKK 
LKAYHSLHGN DWKKIGAMVA RSSLSVALKF SQIGGTRNQG AWSKAETQRL IKAVEDVILK 
KMSPQELREL DSKLQEDPEG RLSIVREKLY KGISWVEVEA RVETRNWMQC KSKWTEILTK 
RMTHGGFVYR GVNALQAKIT LIERLYELNV NDANEIDWED LASAIGDVPP PFVQAKFYKL 
KAACVPFWQK KTFPEIIDYL YKNSLPLLKE KLDKKMKKKD GQIQTPAAPK QDFLFKDIFH 
CDDDSDEGSP EEPSASDVQ

Genular Protein ID: 4222402989

Symbol: Q3TQG6_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TQG6

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 446
Mass: 49913
Checksum: 1AA98DB69AB2BED0
Sequence:

MKGGTSKFKT HTETLYKKKK WSSVSEKRPQ KCPSQCLESK QPQVSVLGKR RRASQTPAQE 
TLESEWPQKA KRKKRRREPQ TPAQETLESE WPQKAKKKKR RGEPQTPTQE SLESEQPRKA 
KRRRKKRKGS QQPTSSLLKT PETFLKAKKT TSAHKKKKNS VLEVDMETGI ILVDKENMEN 
LLETSRKDVD IVYVDMSKGQ RSAKVRETGE LPAAKPQEHG CRELLGDVRS RKKQKHLQKV 
APWDVVQGSQ PESISLPPSE PLSSEDLEGK STEAAVFCKK KSKKNVFRSQ ELEPIPDSLD 
DSETISERLD STHHGGAVGA GEECESTKES HSIKKKSKKK KHKSVALATS SDSASVTDSK 
AKNALVDSSE GSGAVREEDV DHRPAEAEAQ ACSTEKHREA MQRLEPTHEE ESNSESASNS 
AARHISEDRR ESDDSDVDLG SAVRQL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ttf1

Associated with

Other Information

Different domains of the murine RNA polymerase I-specific termination factor mTTF-I serve distinct functions in transcription termination. PubMed ID: 7720715

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Oligomerization of the transcription termination factor TTF-I: implications for the structural organization of ribosomal transcription units. PubMed ID: 9092622

Termination of mammalian rDNA replication: polar arrest of replication fork movement by transcription termination factor TTF-I. PubMed ID: 9267035

RNA polymerase I transcription on nucleosomal templates: the transcription termination factor TTF-I induces chromatin remodeling and relieves transcriptional repression. PubMed ID: 9049305

Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes. PubMed ID: 9582279

The chromatin remodeling complex NoRC and TTF-I cooperate in the regulation of the mammalian rRNA genes in vivo. PubMed ID: 15292447

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The ARF tumor suppressor controls ribosome biogenesis by regulating the RNA polymerase I transcription factor TTF-I. PubMed ID: 20513429

PTRF/Cavin-1 promotes efficient ribosomal RNA transcription in response to metabolic challenges. PubMed ID: 27528195

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073