Genular: Defining Cellular Identity and Function

Details for: Tuba4a

Gene ID: 22145

Symbol: Tuba4a

Ensembl ID: ENSMUSG00000026202

Description: tubulin, alpha 4A

Associated with

Adaptive immune system
(R-MMU-1280218)
Aggrephagy
(R-MMU-9646399)
Anchoring of the basal body to the plasma membrane
(R-MMU-5620912)
Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Asparagine n-linked glycosylation
(R-MMU-446203)
Aurka activation by tpx2
(R-MMU-8854518)
Autophagy
(R-MMU-9612973)
Axon guidance
(R-MMU-422475)
Carboxyterminal post-translational modifications of tubulin
(R-MMU-8955332)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Centrosome maturation
(R-MMU-380287)
Cilium assembly
(R-MMU-5617833)
Copi-dependent golgi-to-er retrograde traffic
(R-MMU-6811434)
Copi-independent golgi-to-er retrograde traffic
(R-MMU-6811436)
Copi-mediated anterograde transport
(R-MMU-6807878)
Cytokine signaling in immune system
(R-MMU-1280215)
Developmental biology
(R-MMU-1266738)
Eml4 and nudc in mitotic spindle formation
(R-MMU-9648025)
Er to golgi anterograde transport
(R-MMU-199977)
Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
G2/m transition
(R-MMU-69275)
Gap junction assembly
(R-MMU-190861)
Gap junction trafficking
(R-MMU-190828)
Gap junction trafficking and regulation
(R-MMU-157858)
Golgi-to-er retrograde transport
(R-MMU-8856688)
Hedgehog 'off' state
(R-MMU-5610787)
Hemostasis
(R-MMU-109582)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-MMU-3371497)
Immune system
(R-MMU-168256)
Interferon signaling
(R-MMU-913531)
Intra-golgi and retrograde golgi-to-er traffic
(R-MMU-6811442)
Intraflagellar transport
(R-MMU-5620924)
Kinesins
(R-MMU-983189)
L1cam interactions
(R-MMU-373760)
Loss of nlp from mitotic centrosomes
(R-MMU-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-MMU-380284)
Macroautophagy
(R-MMU-1632852)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Mhc class ii antigen presentation
(R-MMU-2132295)
Microtubule-dependent trafficking of connexons from golgi to the plasma membrane
(R-MMU-190840)
Mitotic anaphase
(R-MMU-68882)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic metaphase and anaphase
(R-MMU-2555396)
Mitotic prometaphase
(R-MMU-68877)
M phase
(R-MMU-68886)
Nervous system development
(R-MMU-9675108)
Nuclear envelope (ne) reassembly
(R-MMU-2995410)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Pkr-mediated signaling
(R-MMU-9833482)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Post-translational protein modification
(R-MMU-597592)
Recruitment of mitotic centrosome proteins and complexes
(R-MMU-380270)
Recruitment of numa to mitotic centrosomes
(R-MMU-380320)
Recycling pathway of l1
(R-MMU-437239)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Resolution of sister chromatid cohesion
(R-MMU-2500257)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Rho gtpases activate iqgaps
(R-MMU-5626467)
Sealing of the nuclear envelope (ne) by escrt-iii
(R-MMU-9668328)
Selective autophagy
(R-MMU-9663891)
Separation of sister chromatids
(R-MMU-2467813)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-MMU-8852276)
Transport of connexons to the plasma membrane
(R-MMU-190872)
Transport to the golgi and subsequent modification
(R-MMU-948021)
Vesicle-mediated transport
(R-MMU-5653656)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Enzyme binding
(GO:0019899)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Metal ion binding
(GO:0046872)
Microtubule
(GO:0005874)
Microtubule-based process
(GO:0007017)
Microtubule cytoskeleton
(GO:0015630)
Microtubule cytoskeleton organization
(GO:0000226)
Mitotic cell cycle
(GO:0000278)
Nucleotide binding
(GO:0000166)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Structural constituent of cytoskeleton
(GO:0005200)

Other Information

Proteins

Tubulin alpha-4A chain

Genular Protein ID: 2285137530

Symbol: TBA4A_MOUSE

Name: Tubulin alpha-4A chain

UniProtKB Accession Codes:

P68368 P05215 Q3TY31

Database IDs:

Citations:

PubMed ID: 3785200

Title: Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes.

PubMed ID: 3785200

DOI: 10.1128/mcb.6.7.2409-2419.1986

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15890843

Title: Tubulin polyglutamylase enzymes are members of the TTL domain protein family.

PubMed ID: 15890843

DOI: 10.1126/science.1113010

PubMed ID: 16800626

Title: Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease.

PubMed ID: 16800626

DOI: 10.1021/bi060474w

PubMed ID: 19524510

Title: Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.

PubMed ID: 19524510

DOI: 10.1016/j.cell.2009.05.020

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23897886

Title: Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.

PubMed ID: 23897886

DOI: 10.1083/jcb.201305041

PubMed ID: 27965440

Title: CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility.

PubMed ID: 27965440

DOI: 10.1242/dev.139626

PubMed ID: 33414192

Title: Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility.

PubMed ID: 33414192

DOI: 10.1126/science.abd4914

Sequence Information:

Length: 448
Mass: 49924
Checksum: C00ED90A183FE8F2
Sequence:

MRECISVHVG QAGVQMGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFT TFFCETGAGK 
HVPRAVFVDL EPTVIDEIRN GPYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDPVLD 
RIRKLSDQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA 
VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL ISQIVSSITA 
SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLSVAE ITNACFEPAN 
QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIAAIKTKRS IQFVDWCPTG FKVGINYQPP 
TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE 
AREDMAALEK DYEEVGIDSY EDEDEGEE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tuba4a

Associated with

Other Information

Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. PubMed ID: 3785200

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Tubulin polyglutamylase enzymes are members of the TTL domain protein family. PubMed ID: 15890843

Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease. PubMed ID: 16800626

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. PubMed ID: 19524510

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. PubMed ID: 23897886

CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility. PubMed ID: 27965440

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. PubMed ID: 33414192