Genular: Defining Cellular Identity and Function

Details for: Tuba1c

Gene ID: 22146

Symbol: Tuba1c

Ensembl ID: ENSMUSG00000043091

Description: tubulin, alpha 1C

Associated with

Adaptive immune system
(R-MMU-1280218)
Aggrephagy
(R-MMU-9646399)
Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Asparagine n-linked glycosylation
(R-MMU-446203)
Autophagy
(R-MMU-9612973)
Axon guidance
(R-MMU-422475)
Carboxyterminal post-translational modifications of tubulin
(R-MMU-8955332)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cilium assembly
(R-MMU-5617833)
Copi-dependent golgi-to-er retrograde traffic
(R-MMU-6811434)
Copi-independent golgi-to-er retrograde traffic
(R-MMU-6811436)
Copi-mediated anterograde transport
(R-MMU-6807878)
Cytokine signaling in immune system
(R-MMU-1280215)
Developmental biology
(R-MMU-1266738)
Eml4 and nudc in mitotic spindle formation
(R-MMU-9648025)
Er to golgi anterograde transport
(R-MMU-199977)
Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
G2/m transition
(R-MMU-69275)
Gap junction assembly
(R-MMU-190861)
Gap junction trafficking
(R-MMU-190828)
Gap junction trafficking and regulation
(R-MMU-157858)
Golgi-to-er retrograde transport
(R-MMU-8856688)
Hedgehog 'off' state
(R-MMU-5610787)
Hemostasis
(R-MMU-109582)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-MMU-3371497)
Immune system
(R-MMU-168256)
Interferon signaling
(R-MMU-913531)
Intra-golgi and retrograde golgi-to-er traffic
(R-MMU-6811442)
Intraflagellar transport
(R-MMU-5620924)
Kinesins
(R-MMU-983189)
L1cam interactions
(R-MMU-373760)
Macroautophagy
(R-MMU-1632852)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Mhc class ii antigen presentation
(R-MMU-2132295)
Microtubule-dependent trafficking of connexons from golgi to the plasma membrane
(R-MMU-190840)
Mitotic anaphase
(R-MMU-68882)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic metaphase and anaphase
(R-MMU-2555396)
Mitotic prometaphase
(R-MMU-68877)
M phase
(R-MMU-68886)
Nervous system development
(R-MMU-9675108)
Nuclear envelope (ne) reassembly
(R-MMU-2995410)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Pkr-mediated signaling
(R-MMU-9833482)
Post-translational protein modification
(R-MMU-597592)
Recruitment of numa to mitotic centrosomes
(R-MMU-380320)
Recycling pathway of l1
(R-MMU-437239)
Resolution of sister chromatid cohesion
(R-MMU-2500257)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Rho gtpases activate iqgaps
(R-MMU-5626467)
Sealing of the nuclear envelope (ne) by escrt-iii
(R-MMU-9668328)
Selective autophagy
(R-MMU-9663891)
Separation of sister chromatids
(R-MMU-2467813)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-MMU-8852276)
Transport of connexons to the plasma membrane
(R-MMU-190872)
Transport to the golgi and subsequent modification
(R-MMU-948021)
Vesicle-mediated transport
(R-MMU-5653656)
Cytoplasm
(GO:0005737)
Cytoplasmic microtubule
(GO:0005881)
Cytoskeleton
(GO:0005856)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Microtubule
(GO:0005874)
Microtubule-based process
(GO:0007017)
Microtubule cytoskeleton
(GO:0015630)
Microtubule cytoskeleton organization
(GO:0000226)
Mitotic cell cycle
(GO:0000278)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Structural constituent of cytoskeleton
(GO:0005200)

Other Information

Proteins

Tubulin alpha-1C chain

Genular Protein ID: 2145897790

Symbol: TBA1C_MOUSE

Name: Tubulin alpha-1C chain

UniProtKB Accession Codes:

P68373 P05216 Q9CSE9

Database IDs:

Citations:

PubMed ID: 3785200

Title: Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes.

PubMed ID: 3785200

DOI: 10.1128/mcb.6.7.2409-2419.1986

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15890843

Title: Tubulin polyglutamylase enzymes are members of the TTL domain protein family.

PubMed ID: 15890843

DOI: 10.1126/science.1113010

PubMed ID: 16800626

Title: Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease.

PubMed ID: 16800626

DOI: 10.1021/bi060474w

PubMed ID: 19524510

Title: Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.

PubMed ID: 19524510

DOI: 10.1016/j.cell.2009.05.020

PubMed ID: 16954346

Title: Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends.

PubMed ID: 16954346

DOI: 10.1083/jcb.200512058

PubMed ID: 19564401

Title: Motor-dependent microtubule disassembly driven by tubulin tyrosination.

PubMed ID: 19564401

DOI: 10.1083/jcb.200902142

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23897886

Title: Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.

PubMed ID: 23897886

DOI: 10.1083/jcb.201305041

PubMed ID: 26446751

Title: Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle.

PubMed ID: 26446751

DOI: 10.1038/ncomms9526

PubMed ID: 27102488

Title: Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes.

PubMed ID: 27102488

DOI: 10.1126/science.aaf0659

PubMed ID: 29146868

Title: Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.

PubMed ID: 29146868

DOI: 10.1126/science.aao4165

PubMed ID: 33414192

Title: Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility.

PubMed ID: 33414192

DOI: 10.1126/science.abd4914

Sequence Information:

Length: 449
Mass: 49909
Checksum: 0DA9F082D9DC8549
Sequence:

MRECISIHVG QAGVQIGNAC WELYCLEHGI QPDGQMPSDK TIGGGDDSFN TFFSETGAGK 
HVPRAVFVDL EPTVIDEVRT GTYRQLFHPE QLITGKEDAA NNYARGHYTI GKEIIDLVLD 
RIRKLADQCT GLQGFLVFHS FGGGTGSGFT SLLMERLSVD YGKKSKLEFS IYPAPQVSTA 
VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL ISQIVSSITA 
SLRFDGALNV DLTEFQTNLV PYPRIHFPLA TYAPVISAEK AYHEQLTVAE ITNACFEPAN 
QMVKCDPRHG KYMACCLLYR GDVVPKDVNA AIATIKTKRT IQFVDWCPTG FKVGINYQPP 
TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE 
AREDMAALEK DYEEVGADSA EGDDEGEEY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tuba1c

Associated with

Other Information

Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes. PubMed ID: 3785200

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Tubulin polyglutamylase enzymes are members of the TTL domain protein family. PubMed ID: 15890843

Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease. PubMed ID: 16800626

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. PubMed ID: 19524510

Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends. PubMed ID: 16954346

Motor-dependent microtubule disassembly driven by tubulin tyrosination. PubMed ID: 19564401

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. PubMed ID: 23897886

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle. PubMed ID: 26446751

Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes. PubMed ID: 27102488

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. PubMed ID: 29146868

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. PubMed ID: 33414192