Genular: Defining Cellular Identity and Function

Details for: Tubb4a

Gene ID: 22153

Symbol: Tubb4a

Ensembl ID: ENSMUSG00000062591

Description: tubulin, beta 4A class IVA

Associated with

Adaptive immune system
(R-MMU-1280218)
Aggrephagy
(R-MMU-9646399)
Anchoring of the basal body to the plasma membrane
(R-MMU-5620912)
Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Asparagine n-linked glycosylation
(R-MMU-446203)
Aurka activation by tpx2
(R-MMU-8854518)
Autophagy
(R-MMU-9612973)
Axon guidance
(R-MMU-422475)
Carboxyterminal post-translational modifications of tubulin
(R-MMU-8955332)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Centrosome maturation
(R-MMU-380287)
Cilium assembly
(R-MMU-5617833)
Copi-dependent golgi-to-er retrograde traffic
(R-MMU-6811434)
Copi-independent golgi-to-er retrograde traffic
(R-MMU-6811436)
Copi-mediated anterograde transport
(R-MMU-6807878)
Cytokine signaling in immune system
(R-MMU-1280215)
Developmental biology
(R-MMU-1266738)
Eml4 and nudc in mitotic spindle formation
(R-MMU-9648025)
Er to golgi anterograde transport
(R-MMU-199977)
Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
G2/m transition
(R-MMU-69275)
Gap junction assembly
(R-MMU-190861)
Gap junction trafficking
(R-MMU-190828)
Gap junction trafficking and regulation
(R-MMU-157858)
Golgi-to-er retrograde transport
(R-MMU-8856688)
Hedgehog 'off' state
(R-MMU-5610787)
Hemostasis
(R-MMU-109582)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-MMU-3371497)
Immune system
(R-MMU-168256)
Interferon signaling
(R-MMU-913531)
Intra-golgi and retrograde golgi-to-er traffic
(R-MMU-6811442)
Intraflagellar transport
(R-MMU-5620924)
Kinesins
(R-MMU-983189)
L1cam interactions
(R-MMU-373760)
Loss of nlp from mitotic centrosomes
(R-MMU-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-MMU-380284)
Macroautophagy
(R-MMU-1632852)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Mhc class ii antigen presentation
(R-MMU-2132295)
Microtubule-dependent trafficking of connexons from golgi to the plasma membrane
(R-MMU-190840)
Mitotic anaphase
(R-MMU-68882)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic metaphase and anaphase
(R-MMU-2555396)
Mitotic prometaphase
(R-MMU-68877)
M phase
(R-MMU-68886)
Nervous system development
(R-MMU-9675108)
Nuclear envelope (ne) reassembly
(R-MMU-2995410)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Pkr-mediated signaling
(R-MMU-9833482)
Post-translational protein modification
(R-MMU-597592)
Recruitment of mitotic centrosome proteins and complexes
(R-MMU-380270)
Recruitment of numa to mitotic centrosomes
(R-MMU-380320)
Recycling pathway of l1
(R-MMU-437239)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Resolution of sister chromatid cohesion
(R-MMU-2500257)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Rho gtpases activate iqgaps
(R-MMU-5626467)
Sealing of the nuclear envelope (ne) by escrt-iii
(R-MMU-9668328)
Selective autophagy
(R-MMU-9663891)
Separation of sister chromatids
(R-MMU-2467813)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-MMU-8852276)
Transport of connexons to the plasma membrane
(R-MMU-190872)
Transport to the golgi and subsequent modification
(R-MMU-948021)
Vesicle-mediated transport
(R-MMU-5653656)
Axoneme
(GO:0005930)
Calcium ion binding
(GO:0005509)
Cell projection
(GO:0042995)
Cell projection organization
(GO:0030030)
Cilium
(GO:0005929)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Intercellular bridge
(GO:0045171)
Internode region of axon
(GO:0033269)
Metal ion binding
(GO:0046872)
Microtubule
(GO:0005874)
Microtubule-based process
(GO:0007017)
Microtubule cytoskeleton
(GO:0015630)
Microtubule cytoskeleton organization
(GO:0000226)
Mitotic cell cycle
(GO:0000278)
Mitotic spindle
(GO:0072686)
Myelin sheath
(GO:0043209)
Negative regulation of microtubule polymerization
(GO:0031115)
Neuronal cell body
(GO:0043025)
Nucleotide binding
(GO:0000166)
Structural constituent of cytoskeleton
(GO:0005200)

Other Information

Proteins

Tubulin beta-4A chain

Genular Protein ID: 899358554

Symbol: TBB4A_MOUSE

Name: Tubulin beta-4A chain

UniProtKB Accession Codes:

Q9D6F9 Q62364 Q80Y54

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3839797

Title: Five mouse tubulin isotypes and their regulated expression during development.

PubMed ID: 3839797

DOI: 10.1083/jcb.101.3.852

PubMed ID: 15890843

Title: Tubulin polyglutamylase enzymes are members of the TTL domain protein family.

PubMed ID: 15890843

DOI: 10.1126/science.1113010

PubMed ID: 19524510

Title: Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.

PubMed ID: 19524510

DOI: 10.1016/j.cell.2009.05.020

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23897886

Title: Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.

PubMed ID: 23897886

DOI: 10.1083/jcb.201305041

PubMed ID: 33414192

Title: Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility.

PubMed ID: 33414192

DOI: 10.1126/science.abd4914

Sequence Information:

Length: 444
Mass: 49586
Checksum: F7429D057C11A3F5
Sequence:

MREIVHLQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLERINVY YNEATGGNYV 
PRAVLVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDAVLDVV 
RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEFP DRIMNTFSVV PSPKVSDTVV 
EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL 
RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQMFDAKNMM 
AACDPRHGRY LTVAAVFRGR MSMKEVDEQM LSVQSKNSSY FVEWIPNNVK TAVCDIPPRG 
LKMAATFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS 
EYQQYQDATA EEGEFEEEAE EEVA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tubb4a

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Five mouse tubulin isotypes and their regulated expression during development. PubMed ID: 3839797

Tubulin polyglutamylase enzymes are members of the TTL domain protein family. PubMed ID: 15890843

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. PubMed ID: 19524510

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. PubMed ID: 23897886

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. PubMed ID: 33414192