Genular: Defining Cellular Identity and Function

Details for: Tubb5

Gene ID: 22154

Symbol: Tubb5

Ensembl ID: ENSMUSG00000001525

Description: tubulin, beta 5 class I

Associated with

Anchoring of the basal body to the plasma membrane
(R-MMU-5620912)
Aurka activation by tpx2
(R-MMU-8854518)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Centrosome maturation
(R-MMU-380287)
Cilium assembly
(R-MMU-5617833)
G2/m transition
(R-MMU-69275)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Loss of nlp from mitotic centrosomes
(R-MMU-380259)
Loss of proteins required for interphase microtubule organization from the centrosome
(R-MMU-380284)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic prometaphase
(R-MMU-68877)
M phase
(R-MMU-68886)
Neutrophil degranulation
(R-MMU-6798695)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Recruitment of mitotic centrosome proteins and complexes
(R-MMU-380270)
Recruitment of numa to mitotic centrosomes
(R-MMU-380320)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Cell body
(GO:0044297)
Cytoplasm
(GO:0005737)
Cytoplasmic ribonucleoprotein granule
(GO:0036464)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Gtpase activating protein binding
(GO:0032794)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Intercellular bridge
(GO:0045171)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Mhc class i protein binding
(GO:0042288)
Microtubule
(GO:0005874)
Microtubule-based process
(GO:0007017)
Microtubule cytoskeleton
(GO:0015630)
Microtubule cytoskeleton organization
(GO:0000226)
Mitotic cell cycle
(GO:0000278)
Mitotic spindle
(GO:0072686)
Nuclear envelope lumen
(GO:0005641)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Odontoblast differentiation
(GO:0071895)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein domain specific binding
(GO:0019904)
Regulation of synapse organization
(GO:0050807)
Spindle assembly
(GO:0051225)
Structural constituent of cytoskeleton
(GO:0005200)
Tubulin complex
(GO:0045298)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Tubulin beta-5 chain

Genular Protein ID: 2781228871

Symbol: TBB5_MOUSE

Name: Tubulin beta-5 chain

UniProtKB Accession Codes:

P99024 B1B178 P05218 Q3TFB6 Q3THH9 Q3TIL1 Q3UAV4 Q3UF52 Q8WUC1 Q9CY33

Database IDs:

Citations:

PubMed ID: 3782288

Title: The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype.

PubMed ID: 3782288

DOI: 10.1083/jcb.103.5.1903

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3839797

Title: Five mouse tubulin isotypes and their regulated expression during development.

PubMed ID: 3839797

DOI: 10.1083/jcb.101.3.852

PubMed ID: 15890843

Title: Tubulin polyglutamylase enzymes are members of the TTL domain protein family.

PubMed ID: 15890843

DOI: 10.1126/science.1113010

PubMed ID: 16371510

Title: Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1.

PubMed ID: 16371510

DOI: 10.1091/mbc.e05-07-0621

PubMed ID: 18347012

Title: RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules.

PubMed ID: 18347012

DOI: 10.1074/jbc.m709397200

PubMed ID: 19524510

Title: Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.

PubMed ID: 19524510

DOI: 10.1016/j.cell.2009.05.020

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20643351

Title: Pitchfork regulates primary cilia disassembly and left-right asymmetry.

PubMed ID: 20643351

DOI: 10.1016/j.devcel.2010.06.005

PubMed ID: 23246003

Title: Mutations in the beta-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities.

PubMed ID: 23246003

DOI: 10.1016/j.celrep.2012.11.017

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 26637975

Title: Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type.

PubMed ID: 26637975

DOI: 10.1016/j.ajhg.2015.10.014

PubMed ID: 23897886

Title: Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.

PubMed ID: 23897886

DOI: 10.1083/jcb.201305041

PubMed ID: 27965440

Title: CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility.

PubMed ID: 27965440

DOI: 10.1242/dev.139626

PubMed ID: 33414192

Title: Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility.

PubMed ID: 33414192

DOI: 10.1126/science.abd4914

Sequence Information:

Length: 444
Mass: 49671
Checksum: 1E6CD0A36773A103
Sequence:

MREIVHIQAG QCGNQIGAKF WEVISDEHGI DPTGTYHGDS DLQLDRISVY YNEATGGKYV 
PRAILVDLEP GTMDSVRSGP FGQIFRPDNF VFGQSGAGNN WAKGHYTEGA ELVDSVLDVV 
RKEAESCDCL QGFQLTHSLG GGTGSGMGTL LISKIREEYP DRIMNTFSVV PSPKVSDTVV 
EPYNATLSVH QLVENTDETY CIDNEALYDI CFRTLKLTTP TYGDLNHLVS ATMSGVTTCL 
RFPGQLNADL RKLAVNMVPF PRLHFFMPGF APLTSRGSQQ YRALTVPELT QQVFDAKNMM 
AACDPRHGRY LTVAAVFRGR MSMKEVDEQM LNVQNKNSSY FVEWIPNNVK TAVCDIPPRG 
LKMAVTFIGN STAIQELFKR ISEQFTAMFR RKAFLHWYTG EGMDEMEFTE AESNMNDLVS 
EYQQYQDATA EEEEDFGEEA EEEA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tubb5

Associated with

Other Information

The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. PubMed ID: 3782288

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Five mouse tubulin isotypes and their regulated expression during development. PubMed ID: 3839797

Tubulin polyglutamylase enzymes are members of the TTL domain protein family. PubMed ID: 15890843

Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1. PubMed ID: 16371510

RanBP10 is a cytoplasmic guanine nucleotide exchange factor that modulates noncentrosomal microtubules. PubMed ID: 18347012

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. PubMed ID: 19524510

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Pitchfork regulates primary cilia disassembly and left-right asymmetry. PubMed ID: 20643351

Mutations in the beta-tubulin gene TUBB5 cause microcephaly with structural brain abnormalities. PubMed ID: 23246003

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Mutations in Either TUBB or MAPRE2 Cause Circumferential Skin Creases Kunze Type. PubMed ID: 26637975

Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. PubMed ID: 23897886

CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility. PubMed ID: 27965440

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. PubMed ID: 33414192