Genular: Defining Cellular Identity and Function

Details for: Tulp3

Gene ID: 22158

Symbol: Tulp3

Ensembl ID: ENSMUSG00000001521

Description: TUB like protein 3

Associated with

Hedgehog 'off' state
(R-MMU-5610787)
Signaling by hedgehog
(R-MMU-5358351)
Signal transduction
(R-MMU-162582)
9+0 non-motile cilium
(GO:0097731)
Anterior/posterior pattern specification
(GO:0009952)
Axoneme
(GO:0005930)
Bone development
(GO:0060348)
Brain development
(GO:0007420)
Bronchus morphogenesis
(GO:0060434)
Cell projection
(GO:0042995)
Central nervous system neuron differentiation
(GO:0021953)
Ciliary base
(GO:0097546)
Cilium
(GO:0005929)
Cytoplasm
(GO:0005737)
Dorsal/ventral neural tube patterning
(GO:0021904)
Embryonic camera-type eye development
(GO:0031076)
Embryonic digit morphogenesis
(GO:0042733)
Embryonic neurocranium morphogenesis
(GO:0048702)
Enzyme binding
(GO:0019899)
Extracellular region
(GO:0005576)
Ganglion development
(GO:0061548)
G protein-coupled receptor binding
(GO:0001664)
Intraciliary transport particle a binding
(GO:0120160)
Limb development
(GO:0060173)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Neural tube closure
(GO:0001843)
Neural tube development
(GO:0021915)
Neural tube formation
(GO:0001841)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatidylinositol binding
(GO:0035091)
Plasma membrane
(GO:0005886)
Protein-containing complex binding
(GO:0044877)
Protein localization to cilium
(GO:0061512)
Regulation of g protein-coupled receptor signaling pathway
(GO:0008277)
Regulation of smoothened signaling pathway
(GO:0008589)
Smoothened signaling pathway
(GO:0007224)
Smoothened signaling pathway involved in dorsal/ventral neural tube patterning
(GO:0060831)

Other Information

Proteins

Tubby-like protein 3

Genular Protein ID: 2230997180

Symbol: TULP3_MOUSE

Name: Tubby-like protein 3

UniProtKB Accession Codes:

O88413

Database IDs:

Citations:

PubMed ID: 9828123

Title: Molecular characterization of a novel tubby gene family member, TULP3, in mouse and humans.

PubMed ID: 9828123

DOI: 10.1006/geno.1998.5567

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11406614

Title: Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice.

PubMed ID: 11406614

DOI: 10.1093/hmg/10.12.1325

PubMed ID: 19334287

Title: Tulp3 is a critical repressor of mouse hedgehog signaling.

PubMed ID: 19334287

DOI: 10.1002/dvdy.21926

PubMed ID: 19695251

Title: Unconventional secretion of tubby and tubby-like protein 1.

PubMed ID: 19695251

DOI: 10.1016/j.febslet.2009.08.015

PubMed ID: 19286674

Title: Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling.

PubMed ID: 19286674

DOI: 10.1093/hmg/ddp113

PubMed ID: 21209331

Title: Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components.

PubMed ID: 21209331

DOI: 10.1073/pnas.1011410108

PubMed ID: 31761534

Title: Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis.

PubMed ID: 31761534

DOI: 10.1016/j.cell.2019.11.005

Sequence Information:

Length: 460
Mass: 51231
Checksum: 02EBC62899BB8B3B
Sequence:

MEAARCAPGP RGDSAFDDET LRLRQLKLDN QRALLEKKQR KKRLEPLMVQ PNPEARLRRL 
KPRGSEEHTP LVDPQMPRSD VILHGIDGPA AFLKPEAQDL ESKPQVLSVG SPAPEEGTEG 
SADGESPEET APKPDLQEIL QKHGILSSVN YDEEPDKEED EGGNLSSPSA RSEESAAASQ 
KAASETGASG VTAQQGDAQL GEVENLEDFA YSPAPRGVTV KCKVTRDKKG MDRGLFPTYY 
MHLEREENRK IFLLAGRKRK KSKTSNYLVS TDPTDLSREG ESYIGKLRSN LMGTKFTVYD 
HGVNPVKAQG LVEKAHTRQE LAAICYETNV LGFKGPRKMS VIIPGMNMNH ERIPFRPRNE 
HESLLSKWQN KSMENLIELH NKAPVWNDDT QSYVLNFHGR VTQASVKNFQ IVHGNDPDYI 
VMQFGRVADD VFTLDYNYPL CALQAFAIGL SSFDSKLACE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tulp3

Associated with

Other Information

Molecular characterization of a novel tubby gene family member, TULP3, in mouse and humans. PubMed ID: 9828123

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice. PubMed ID: 11406614

Tulp3 is a critical repressor of mouse hedgehog signaling. PubMed ID: 19334287

Unconventional secretion of tubby and tubby-like protein 1. PubMed ID: 19695251

Tubby-like protein 3 (TULP3) regulates patterning in the mouse embryo through inhibition of Hedgehog signaling. PubMed ID: 19286674

Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components. PubMed ID: 21209331

Omega-3 Fatty Acids Activate Ciliary FFAR4 to Control Adipogenesis. PubMed ID: 31761534