Details for: Twist1

Gene ID: 22160

Symbol: Twist1

Ensembl ID: ENSMUSG00000035799

Description: twist basic helix-loop-helix transcription factor 1

Associated with

  • Aortic valve morphogenesis
    (GO:0003180)
  • Bhlh transcription factor binding
    (GO:0043425)
  • Cardiac neural crest cell development involved in outflow tract morphogenesis
    (GO:0061309)
  • Cardiac neural crest cell migration involved in outflow tract morphogenesis
    (GO:0003253)
  • Cell differentiation
    (GO:0030154)
  • Cell proliferation involved in heart valve development
    (GO:2000793)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Cranial suture morphogenesis
    (GO:0060363)
  • Developmental process
    (GO:0032502)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna-binding transcription repressor activity
    (GO:0001217)
  • Dna binding
    (GO:0003677)
  • E-box binding
    (GO:0070888)
  • Embryonic camera-type eye formation
    (GO:0060900)
  • Embryonic cranial skeleton morphogenesis
    (GO:0048701)
  • Embryonic digit morphogenesis
    (GO:0042733)
  • Embryonic forelimb morphogenesis
    (GO:0035115)
  • Embryonic hindlimb morphogenesis
    (GO:0035116)
  • Embryonic limb morphogenesis
    (GO:0030326)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Endocardial cushion morphogenesis
    (GO:0003203)
  • Energy homeostasis
    (GO:0097009)
  • Eyelid development in camera-type eye
    (GO:0061029)
  • Hindlimb morphogenesis
    (GO:0035137)
  • Histone deacetylase binding
    (GO:0042826)
  • Identical protein binding
    (GO:0042802)
  • In utero embryonic development
    (GO:0001701)
  • Macrophage cytokine production
    (GO:0010934)
  • Mitral valve morphogenesis
    (GO:0003183)
  • Multicellular organism development
    (GO:0007275)
  • Muscle organ development
    (GO:0007517)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cell differentiation
    (GO:0045596)
  • Negative regulation of cellular senescence
    (GO:2000773)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of dna damage response, signal transduction by p53 class mediator
    (GO:0043518)
  • Negative regulation of double-strand break repair
    (GO:2000780)
  • Negative regulation of macrophage cytokine production
    (GO:0010936)
  • Negative regulation of mirna transcription
    (GO:1902894)
  • Negative regulation of molecular function
    (GO:0044092)
  • Negative regulation of osteoblast differentiation
    (GO:0045668)
  • Negative regulation of peroxisome proliferator activated receptor signaling pathway
    (GO:0035359)
  • Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051898)
  • Negative regulation of skeletal muscle tissue development
    (GO:0048642)
  • Negative regulation of striated muscle tissue development
    (GO:0045843)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of tumor necrosis factor production
    (GO:0032720)
  • Neural tube closure
    (GO:0001843)
  • Neuron migration
    (GO:0001764)
  • Nucleus
    (GO:0005634)
  • Ossification
    (GO:0001503)
  • Osteoblast differentiation
    (GO:0001649)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell motility
    (GO:2000147)
  • Positive regulation of dna-templated transcription initiation
    (GO:2000144)
  • Positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
    (GO:2000802)
  • Positive regulation of epithelial cell proliferation
    (GO:0050679)
  • Positive regulation of epithelial to mesenchymal transition
    (GO:0010718)
  • Positive regulation of fatty acid beta-oxidation
    (GO:0032000)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of monocyte chemotactic protein-1 production
    (GO:0071639)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of transcription regulatory region dna binding
    (GO:2000679)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Protein domain specific binding
    (GO:0019904)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of bone mineralization
    (GO:0030500)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rhythmic process
    (GO:0048511)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Stem cell differentiation
    (GO:0048863)
  • Transcription coregulator binding
    (GO:0001221)
  • Tumor necrosis factor production
    (GO:0032640)

Other Information

Genular Protein ID: 1289613561

Symbol: TWST1_MOUSE

Name: Twist-related protein 1

UniProtKB Accession Codes:

P26687

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 4 Ensembl 1 GO 74 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 1840517

Title: The M-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist genes.

PubMed ID: 1840517

DOI: 10.1016/0012-1606(91)90086-i

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9343420

Title: The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, Twist.

PubMed ID: 9343420

DOI: 10.1128/mcb.17.11.6563

PubMed ID: 12553906

Title: Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity.

PubMed ID: 12553906

DOI: 10.1016/s0092-8674(03)00002-3

PubMed ID: 14645221

Title: Histone acetyltransferase-dependent chromatin remodeling and the vascular clock.

PubMed ID: 14645221

DOI: 10.1074/jbc.m311973200

PubMed ID: 16502419

Title: Twist1 dimer selection regulates cranial suture patterning and fusion.

PubMed ID: 16502419

DOI: 10.1002/dvdy.20717

PubMed ID: 17893140

Title: Mechanism of transcriptional activation by the proto-oncogene Twist1.

PubMed ID: 17893140

DOI: 10.1074/jbc.m707085200

PubMed ID: 23395635

Title: Tcf15 primes pluripotent cells for differentiation.

PubMed ID: 23395635

DOI: 10.1016/j.celrep.2013.01.017

Sequence Information:

  • Length: 206
  • Mass: 21198
  • Checksum: 618AD8E9BE87C555
  • Sequence:
    • MMQDVSSSPV SPADDSLSNS EEEPDRQQPA SGKRGARKRR SSRRSAGGSA GPGGATGGGI 
GGGDEPGSPA QGKRGKKSAG GGGGGGAGGG GGGGGGSSSG GGSPQSYEEL QTQRVMANVR 
ERQRTQSLNE AFAALRKIIP TLPSDKLSKI QTLKLAARYI DFLYQVLQSD ELDSKMASCS 
YVAHERLSYA FSVWRMEGAW SMSASH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.