Details for: Tnfsf4

Gene ID: 22164

Symbol: Tnfsf4

Ensembl ID: ENSMUSG00000026700

Description: tumor necrosis factor (ligand) superfamily, member 4

Associated with

  • Cytokine signaling in immune system
    (R-MMU-1280215)
  • Immune system
    (R-MMU-168256)
  • Tnfr2 non-canonical nf-kb pathway
    (R-MMU-5668541)
  • Tnfs bind their physiological receptors
    (R-MMU-5669034)
  • Acute inflammatory response
    (GO:0002526)
  • Blood vessel development
    (GO:0001568)
  • Cd4-positive, alpha-beta t cell costimulation
    (GO:0035783)
  • Cell surface
    (GO:0009986)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to nitrogen dioxide
    (GO:0035714)
  • Cellular response to prostaglandin e stimulus
    (GO:0071380)
  • Cholesterol metabolic process
    (GO:0008203)
  • Cytokine activity
    (GO:0005125)
  • Defense response to nematode
    (GO:0002215)
  • Extracellular space
    (GO:0005615)
  • Immune response
    (GO:0006955)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Membrane
    (GO:0016020)
  • Memory t cell activation
    (GO:0035709)
  • Negative regulation of activation-induced cell death of t cells
    (GO:0070236)
  • Negative regulation of cytokine production
    (GO:0001818)
  • Negative regulation of dna-binding transcription factor activity
    (GO:0043433)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of extrinsic apoptotic signaling pathway
    (GO:2001237)
  • Negative regulation of interleukin-17 production
    (GO:0032700)
  • Negative regulation of regulatory t cell differentiation
    (GO:0045590)
  • Negative regulation of t-helper 1 cell differentiation
    (GO:0045626)
  • Negative regulation of t cell apoptotic process
    (GO:0070233)
  • Negative regulation of type ii interferon production
    (GO:0032689)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of alpha-beta t cell proliferation
    (GO:0046641)
  • Positive regulation of b cell activation
    (GO:0050871)
  • Positive regulation of cd4-positive, alpha-beta t cell costimulation
    (GO:1900281)
  • Positive regulation of cd4-positive, alpha-beta t cell differentiation
    (GO:0043372)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of immune effector process
    (GO:0002699)
  • Positive regulation of immunoglobulin mediated immune response
    (GO:0002891)
  • Positive regulation of immunoglobulin production
    (GO:0002639)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-2 production
    (GO:0032743)
  • Positive regulation of interleukin-4 production
    (GO:0032753)
  • Positive regulation of interleukin-4-dependent isotype switching to ige isotypes
    (GO:2000572)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of interleukin-12 production
    (GO:0032735)
  • Positive regulation of interleukin-13 production
    (GO:0032736)
  • Positive regulation of memory t cell activation
    (GO:2000568)
  • Positive regulation of memory t cell differentiation
    (GO:0043382)
  • Positive regulation of t-helper 2 cell activation
    (GO:2000570)
  • Positive regulation of t-helper 2 cell differentiation
    (GO:0045630)
  • Positive regulation of t cell costimulation
    (GO:2000525)
  • Positive regulation of t cell cytokine production
    (GO:0002726)
  • Positive regulation of t cell migration
    (GO:2000406)
  • Positive regulation of t cell proliferation
    (GO:0042102)
  • Positive regulation of type 2 immune response
    (GO:0002830)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Protein binding
    (GO:0005515)
  • Regulation of adaptive immune response
    (GO:0002819)
  • Regulation of inflammatory response
    (GO:0050727)
  • Response to nitrogen dioxide
    (GO:0035713)
  • Response to virus
    (GO:0009615)
  • T-helper 2 cell activation
    (GO:0035712)
  • T cell proliferation
    (GO:0042098)
  • Tumor necrosis factor receptor binding
    (GO:0005164)
  • Tumor necrosis factor receptor superfamily binding
    (GO:0032813)

Other Information

Genular Protein ID: 3840727753

Symbol: TNFL4_MOUSE

Name: Tumor necrosis factor ligand superfamily member 4

UniProtKB Accession Codes:

P43488

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DIP 1 DNASU 1 EMBL 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 61 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PaxDb 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8076595

Title: Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34.

PubMed ID: 8076595

DOI: 10.1002/j.1460-2075.1994.tb06715.x

PubMed ID: 16905106

Title: The crystal structure of the costimulatory OX40-OX40L complex.

PubMed ID: 16905106

DOI: 10.1016/j.str.2006.06.015

Sequence Information:

  • Length: 198
  • Mass: 22255
  • Checksum: F4B23A7CC0590459
  • Sequence:
    • MEGEGVQPLD ENLENGSRPR FKWKKTLRLV VSGIKGAGML LCFIYVCLQL SSSPAKDPPI 
QRLRGAVTRC EDGQLFISSY KNEYQTMEVQ NNSVVIKCDG LYIIYLKGSF FQEVKIDLHF 
REDHNPISIP MLNDGRRIVF TVVASLAFKD KVYLTVNAPD TLCEHLQIND GELIVVQLTP 
GYCAPEGSYH STVNQVPL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.