Details for: Tyr

Gene ID: 22173

Symbol: Tyr

Ensembl ID: ENSMUSG00000004651

Description: tyrosinase

Associated with

Other Information

Genular Protein ID: 2361999538

Symbol: TYRO_MOUSE

Name: Tyrosinase

UniProtKB Accession Codes:

P11344

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 DNASU 1 DrugCentral 1 EC 3 ELM 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 18 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 4 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 3134020

Title: Sequence analysis of mouse tyrosinase cDNA and the effect of melanotropin on its gene expression.

PubMed ID: 3134020

DOI: 10.1016/s0006-291x(88)81370-6

PubMed ID: 3141148

Title: Functional analysis of alternatively spliced tyrosinase gene transcripts.

PubMed ID: 3141148

DOI: 10.1002/j.1460-2075.1988.tb03126.x

PubMed ID: 2567165

Title: Molecular basis of mouse Himalayan mutation.

PubMed ID: 2567165

DOI: 10.1016/0006-291x(89)91588-x

PubMed ID: 2494997

Title: Isolation and characterization of variant cDNAs encoding mouse tyrosinase.

PubMed ID: 2494997

DOI: 10.1016/0006-291x(89)90072-7

PubMed ID: 2517217

Title: Melanin production in cultured albino melanocytes transfected with mouse tyrosinase cDNA.

PubMed ID: 2517217

DOI: 10.1266/jjg.64.121

PubMed ID: 2507645

Title: Isolation, chromosomal mapping, and expression of the mouse tyrosinase gene.

PubMed ID: 2507645

DOI: 10.1111/1523-1747.ep12319693

PubMed ID: 2110899

Title: A point mutation in the tyrosinase gene of BALB/c albino mouse causing the cysteine-->serine substitution at position 85.

PubMed ID: 2110899

DOI: 10.1111/j.1432-1033.1990.tb15510.x

PubMed ID: 1537333

Title: A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase.

PubMed ID: 1537333

DOI: 10.1002/j.1460-2075.1992.tb05082.x

PubMed ID: 26620560

Title: RUTBC1 functions as a GTPase-activating protein for Rab32/38 and regulates melanogenic enzyme trafficking in melanocytes.

PubMed ID: 26620560

DOI: 10.1074/jbc.m115.684043

PubMed ID: 35469906

Title: Ablation of H+/glucose Exporter SLC45A2 Enhances Melanosomal Glycolysis to Inhibit Melanin Biosynthesis and Promote Melanoma Metastasis.

PubMed ID: 35469906

DOI: 10.1016/j.jid.2022.04.008

PubMed ID: 2118105

Title: Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice.

PubMed ID: 2118105

DOI: 10.1002/j.1460-2075.1990.tb07470.x

Sequence Information:

  • Length: 533
  • Mass: 60606
  • Checksum: A4C109A97CBD5D6A
  • Sequence:
    • MFLAVLYCLL WSFQISDGHF PRACASSKNL LAKECCPPWM GDGSPCGQLS GRGSCQDILL 
SSAPSGPQFP FKGVDDRESW PSVFYNRTCQ CSGNFMGFNC GNCKFGFGGP NCTEKRVLIR 
RNIFDLSVSE KNKFFSYLTL AKHTISSVYV IPTGTYGQMN NGSTPMFNDI NIYDLFVWMH 
YYVSRDTLLG GSEIWRDIDF AHEAPGFLPW HRLFLLLWEQ EIRELTGDEN FTVPYWDWRD 
AENCDICTDE YLGGRHPENP NLLSPASFFS SWQIICSRSE EYNSHQVLCD GTPEGPLLRN 
PGNHDKAKTP RLPSSADVEF CLSLTQYESG SMDRTANFSF RNTLEGFASP LTGIADPSQS 
SMHNALHIFM NGTMSQVQGS ANDPIFLLHH AFVDSIFEQW LRRHRPLLEV YPEANAPIGH 
NRDSYMVPFI PLYRNGDFFI TSKDLGYDYS YLQESDPGFY RNYIEPYLEQ ASRIWPWLLG 
AALVGAVIAA ALSGLSSRLC LQKKKKKKQP QEERQPLLMD KDDYHSLLYQ SHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.