Genular: Defining Cellular Identity and Function

Details for: Tyro3

Gene ID: 22174

Symbol: Tyro3

Ensembl ID: ENSMUSG00000027298

Description: TYRO3 protein tyrosine kinase 3

Associated with

Apoptotic cell clearance
(GO:0043277)
Atp binding
(GO:0005524)
Cell adhesion
(GO:0007155)
Cell migration
(GO:0016477)
Cell surface
(GO:0009986)
Endoplasmic reticulum membrane
(GO:0005789)
Establishment of localization in cell
(GO:0051649)
Forebrain cell migration
(GO:0021885)
Kinase activity
(GO:0016301)
Lymphocyte activation
(GO:0046649)
Membrane
(GO:0016020)
Multicellular organism development
(GO:0007275)
Natural killer cell differentiation
(GO:0001779)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of innate immune response
(GO:0045824)
Negative regulation of lymphocyte activation
(GO:0051250)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of toll-like receptor signaling pathway
(GO:0034122)
Nervous system development
(GO:0007399)
Neuron apoptotic process
(GO:0051402)
Neuron cellular homeostasis
(GO:0070050)
Neuron migration
(GO:0001764)
Neuropeptide signaling pathway
(GO:0007218)
Nuclear envelope
(GO:0005635)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Ovulation cycle
(GO:0042698)
Phagocytosis
(GO:0006909)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Platelet aggregation
(GO:0070527)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of viral life cycle
(GO:1903902)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Receptor complex
(GO:0043235)
Secretion by cell
(GO:0032940)
Spermatogenesis
(GO:0007283)
Substrate adhesion-dependent cell spreading
(GO:0034446)
Transferase activity
(GO:0016740)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Vagina development
(GO:0060068)
Virus receptor activity
(GO:0001618)

Other Information

Proteins

Tyrosine-protein kinase receptor TYRO3

Genular Protein ID: 986608106

Symbol: TYRO3_MOUSE

Name: Tyrosine-protein kinase receptor TYRO3

UniProtKB Accession Codes:

P55144 O09070 O09080 P70285 Q60752 Q62482 Q62483 Q62484 Q6NZM6 Q78E85 Q78E87

Database IDs:

Citations:

PubMed ID: 7511603

Title: RSE, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain.

PubMed ID: 7511603

DOI: 10.1016/s0021-9258(17)34118-2

PubMed ID: 7857657

Title: Isolation of a receptor tyrosine kinase (DTK) from embryonic stem cells: structure, genetic mapping and analysis of expression.

PubMed ID: 7857657

DOI: 10.3109/08977199409001054

PubMed ID: 8058320

Title: Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase.

PubMed ID: 8058320

PubMed ID: 8108111

Title: brt, a mouse gene encoding a novel receptor-type protein-tyrosine kinase, is preferentially expressed in the brain.

PubMed ID: 8108111

PubMed ID: 8108112

Title: Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain.

PubMed ID: 8108112

PubMed ID: 7723626

Title: Isolation and expression analysis of tyro3, a murine growth factor receptor tyrosine kinase preferentially expressed in adult brain.

PubMed ID: 7723626

DOI: 10.1016/0169-328x(94)00216-2

PubMed ID: 8889809

Title: Structure and expression of a murine homologue of sky receptor tyrosine kinase.

PubMed ID: 8889809

DOI: 10.1093/oxfordjournals.jbchem.a021408

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7784069

Title: Identification of alternative exons, including a novel exon, in the tyrosine kinase receptor gene Etk2/tyro3 that explain differences in 5' cDNA sequences.

PubMed ID: 7784069

PubMed ID: 10227296

Title: Tyro-3 family receptors are essential regulators of mammalian spermatogenesis.

PubMed ID: 10227296

DOI: 10.1038/19554

PubMed ID: 10627473

Title: Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway.

PubMed ID: 10627473

PubMed ID: 15650770

Title: Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy.

PubMed ID: 15650770

DOI: 10.1172/jci22079

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20978472

Title: Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis.

PubMed ID: 20978472

DOI: 10.1038/emboj.2010.265

PubMed ID: 21084607

Title: Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region.

PubMed ID: 21084607

DOI: 10.1523/jneurosci.4437-10.2010

PubMed ID: 20363878

Title: Sertoli cell-initiated testicular innate immune response through toll-like receptor-3 activation is negatively regulated by Tyro3, Axl, and mer receptors.

PubMed ID: 20363878

DOI: 10.1210/en.2009-1498

PubMed ID: 21291561

Title: Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway.

PubMed ID: 21291561

DOI: 10.1186/1750-1326-6-13

Sequence Information:

Length: 880
Mass: 96208
Checksum: 2794316CB0034617
Sequence:

MALRRSMGWP GLRPLLLAGL ASLLLPGSAA AGLKLMGAPV KMTVSQGQPV KLNCSVEGME 
DPDIHWMKDG TVVQNASQVS ISISEHSWIG LLSLKSVERS DAGLYWCQVK DGEETKISQS 
VWLTVEGVPF FTVEPKDLAV PPNAPFQLSC EAVGPPEPVT IYWWRGLTKV GGPAPSPSVL 
NVTGVTQRTE FSCEARNIKG LATSRPAIVR LQAPPAAPFN TTVTTISSYN ASVAWVPGAD 
GLALLHSCTV QVAHAPGEWE ALAVVVPVPP FTCLLRNLAP ATNYSLRVRC ANALGPSPYG 
DWVPFQTKGL APARAPQNFH AIRTDSGLIL EWEEVIPEDP GEGPLGPYKL SWVQENGTQD 
ELMVEGTRAN LTDWDPQKDL ILRVCASNAI GDGPWSQPLV VSSHDHAGRQ GPPHSRTSWV 
PVVLGVLTAL ITAAALALIL LRKRRKETRF GQAFDSVMAR GEPAVHFRAA RSFNRERPER 
IEATLDSLGI SDELKEKLED VLIPEQQFTL GRMLGKGEFG SVREAQLKQE DGSFVKVAVK 
MLKADIIASS DIEEFLREAA CMKEFDHPHV AKLVGVSLRS RAKGRLPIPM VILPFMKHGD 
LHAFLLASRI GENPFNLPLQ TLVRFMVDIA CGMEYLSSRN FIHRDLAARN CMLAEDMTVC 
VADFGLSRKI YSGDYYRQGC ASKLPVKWLA LESLADNLYT VHSDVWAFGV TMWEIMTRGQ 
TPYAGIENAE IYNYLIGGNR LKQPPECMEE VYDLMYQCWS ADPKQRPSFT CLRMELENIL 
GHLSVLSTSQ DPLYINIERA EQPTESGSPE VHCGERSSSE AGDGSGVGAV GGIPSDSRYI 
FSPGGLSESP GQLEQQPESP LNENQRLLLL QQGLLPHSSC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tyro3

Associated with

Other Information

RSE, a novel receptor-type tyrosine kinase with homology to Axl/Ufo, is expressed at high levels in the brain. PubMed ID: 7511603

Isolation of a receptor tyrosine kinase (DTK) from embryonic stem cells: structure, genetic mapping and analysis of expression. PubMed ID: 7857657

Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase. PubMed ID: 8058320

brt, a mouse gene encoding a novel receptor-type protein-tyrosine kinase, is preferentially expressed in the brain. PubMed ID: 8108111

Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain. PubMed ID: 8108112

Isolation and expression analysis of tyro3, a murine growth factor receptor tyrosine kinase preferentially expressed in adult brain. PubMed ID: 7723626

Structure and expression of a murine homologue of sky receptor tyrosine kinase. PubMed ID: 8889809

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of alternative exons, including a novel exon, in the tyrosine kinase receptor gene Etk2/tyro3 that explain differences in 5' cDNA sequences. PubMed ID: 7784069

Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. PubMed ID: 10227296

Transforming activity of receptor tyrosine kinase tyro3 is mediated, at least in part, by the PI3 kinase-signaling pathway. PubMed ID: 10627473

Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. PubMed ID: 15650770

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Tubby and tubby-like protein 1 are new MerTK ligands for phagocytosis. PubMed ID: 20978472

Protein S protects neurons from excitotoxic injury by activating the TAM receptor Tyro3-phosphatidylinositol 3-kinase-Akt pathway through its sex hormone-binding globulin-like region. PubMed ID: 21084607

Sertoli cell-initiated testicular innate immune response through toll-like receptor-3 activation is negatively regulated by Tyro3, Axl, and mer receptors. PubMed ID: 20363878

Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl D-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. PubMed ID: 21291561