Genular: Defining Cellular Identity and Function

Details for: Ube2i

Gene ID: 22196

Symbol: Ube2i

Ensembl ID: ENSMUSG00000015120

Description: ubiquitin-conjugating enzyme E2I

Associated with

Cell cycle, mitotic
(R-MMU-69278)
Dna double-strand break repair
(R-MMU-5693532)
Dna double strand break response
(R-MMU-5693606)
Dna repair
(R-MMU-73894)
Formation of incision complex in gg-ner
(R-MMU-5696395)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Global genome nucleotide excision repair (gg-ner)
(R-MMU-5696399)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Homology directed repair
(R-MMU-5693538)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of proteins
(R-MMU-392499)
Metabolism of steroids
(R-MMU-8957322)
Mitotic anaphase
(R-MMU-68882)
Mitotic metaphase and anaphase
(R-MMU-2555396)
M phase
(R-MMU-68886)
Negative regulation of activity of tfap2 (ap-2) family transcription factors
(R-MMU-8866904)
Nuclear envelope (ne) reassembly
(R-MMU-2995410)
Nucleotide excision repair
(R-MMU-5696398)
Post-translational protein modification
(R-MMU-597592)
Postmitotic nuclear pore complex (npc) reformation
(R-MMU-9615933)
Processing and activation of sumo
(R-MMU-3215018)
Processing of dna double-strand break ends
(R-MMU-5693607)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-MMU-5693565)
Rna polymerase ii transcription
(R-MMU-73857)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumo is transferred from e1 to e2 (ube2i, ubc9)
(R-MMU-3065678)
Sumoylation
(R-MMU-2990846)
Sumoylation of chromatin organization proteins
(R-MMU-4551638)
Sumoylation of dna damage response and repair proteins
(R-MMU-3108214)
Sumoylation of dna methylation proteins
(R-MMU-4655427)
Sumoylation of dna replication proteins
(R-MMU-4615885)
Sumoylation of immune response proteins
(R-MMU-4755510)
Sumoylation of intracellular receptors
(R-MMU-4090294)
Sumoylation of nuclear envelope proteins
(R-MMU-9793242)
Sumoylation of rna binding proteins
(R-MMU-4570464)
Sumoylation of sumoylation proteins
(R-MMU-4085377)
Sumoylation of transcription cofactors
(R-MMU-3899300)
Sumoylation of transcription factors
(R-MMU-3232118)
Sumoylation of ubiquitinylation proteins
(R-MMU-3232142)
Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
(R-MMU-8864260)
Vitamin d (calciferol) metabolism
(R-MMU-196791)
Atp binding
(GO:0005524)
Bhlh transcription factor binding
(GO:0043425)
Cell cycle
(GO:0007049)
Cell division
(GO:0051301)
Chromosome segregation
(GO:0007059)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Enzyme binding
(GO:0019899)
Fibrillar center
(GO:0001650)
Hlh domain binding
(GO:0043398)
Ionotropic glutamate receptor binding
(GO:0035255)
Multicellular organism development
(GO:0007275)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear body
(GO:0016604)
Nuclear envelope
(GO:0005635)
Nuclear export
(GO:0051168)
Nuclear pore
(GO:0005643)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Pml body
(GO:0016605)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of sumo transferase activity
(GO:1903755)
Protein binding
(GO:0005515)
Protein modification process
(GO:0036211)
Protein sumoylation
(GO:0016925)
Ring-like zinc finger domain binding
(GO:0071535)
Small protein activating enzyme binding
(GO:0044388)
Sumo conjugating enzyme activity
(GO:0061656)
Sumo ligase complex
(GO:0106068)
Sumo transferase activity
(GO:0019789)
Transcription coregulator binding
(GO:0001221)
Transcription factor binding
(GO:0008134)
Transferase activity
(GO:0016740)
Transferase complex
(GO:1990234)
Ubiquitin-protein transferase activity
(GO:0004842)

Other Information

Proteins

SUMO-conjugating enzyme UBC9

Genular Protein ID: 509181539

Symbol: UBC9_MOUSE

Name: SUMO-conjugating enzyme UBC9

UniProtKB Accession Codes:

P63280 P50550 Q15698 Q6RUT3 Q86VB3

Database IDs:

Citations:

PubMed ID: 8839844

Title: E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha.

PubMed ID: 8839844

PubMed ID: 8824223

Title: mUBC9, a novel adenovirus E1A-interacting protein that complements a yeast cell cycle defect.

PubMed ID: 8824223

DOI: 10.1074/jbc.271.42.25906

PubMed ID: 8610150

Title: Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes.

PubMed ID: 8610150

DOI: 10.1073/pnas.93.7.2958

PubMed ID: 9409784

Title: The mUBC9 murine ubiquitin conjugating enzyme interacts with the E2A transcription factors.

PubMed ID: 9409784

DOI: 10.1016/s0378-1119(97)00444-7

PubMed ID: 9223278

Title: Direct involvement of the ubiquitin-conjugating enzyme Ubc9/Hus5 in the degradation of IkappaBalpha.

PubMed ID: 9223278

DOI: 10.1073/pnas.94.15.7862

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 10535925

Title: Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1.

PubMed ID: 10535925

DOI: 10.1073/pnas.96.22.12350

PubMed ID: 16326389

Title: The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice.

PubMed ID: 16326389

DOI: 10.1016/j.devcel.2005.10.007

PubMed ID: 12633878

Title: A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9.

PubMed ID: 12633878

DOI: 10.1016/s0014-5793(03)00153-4

PubMed ID: 16352559

Title: Interaction of moloney murine leukemia virus capsid with Ubc9 and PIASy mediates SUMO-1 addition required early in infection.

PubMed ID: 16352559

DOI: 10.1128/jvi.80.1.342-352.2006

PubMed ID: 17187077

Title: SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells.

PubMed ID: 17187077

DOI: 10.1038/nsmb1185

PubMed ID: 18681895

Title: BCL11A is a SUMOylated protein and recruits SUMO-conjugation enzymes in its nuclear body.

PubMed ID: 18681895

DOI: 10.1111/j.1365-2443.2008.01216.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22214662

Title: The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G(1) arrest.

PubMed ID: 22214662

DOI: 10.4161/cc.11.2.18999

PubMed ID: 26074071

Title: SUMOylation is an inhibitory constraint that regulates the prion-like aggregation and activity of CPEB3.

PubMed ID: 26074071

DOI: 10.1016/j.celrep.2015.04.061

PubMed ID: 9261152

Title: Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system.

PubMed ID: 9261152

DOI: 10.1074/jbc.272.34.21381

Sequence Information:

Length: 158
Mass: 18007
Checksum: E2C826E9C8D0683D
Sequence:

MSGIALSRLA QERKAWRKDH PFGFVAVPTK NPDGTMNLMN WECAIPGKKG TPWEGGLFKL 
RMLFKDDYPS SPPKCKFEPP LFHPNVYPSG TVCLSILEED KDWRPAITIK QILLGIQELL 
NEPNIQDPAQ AEAYTIYCQN RVEYEKRVRA QAKKFAPS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ube2i

Associated with

Other Information

E3, a hematopoietic-specific transcript directly regulated by the retinoic acid receptor alpha. PubMed ID: 8839844

mUBC9, a novel adenovirus E1A-interacting protein that complements a yeast cell cycle defect. PubMed ID: 8824223

Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes. PubMed ID: 8610150

The mUBC9 murine ubiquitin conjugating enzyme interacts with the E2A transcription factors. PubMed ID: 9409784

Direct involvement of the ubiquitin-conjugating enzyme Ubc9/Hus5 in the degradation of IkappaBalpha. PubMed ID: 9223278

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Covalent modification of the homeodomain-interacting protein kinase 2 (HIPK2) by the ubiquitin-like protein SUMO-1. PubMed ID: 10535925

The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice. PubMed ID: 16326389

A novel protein phosphatase 2C family member (PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9. PubMed ID: 12633878

Interaction of moloney murine leukemia virus capsid with Ubc9 and PIASy mediates SUMO-1 addition required early in infection. PubMed ID: 16352559

SUMOylation of Tr2 orphan receptor involves Pml and fine-tunes Oct4 expression in stem cells. PubMed ID: 17187077

BCL11A is a SUMOylated protein and recruits SUMO-conjugation enzymes in its nuclear body. PubMed ID: 18681895

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G(1) arrest. PubMed ID: 22214662

SUMOylation is an inhibitory constraint that regulates the prion-like aggregation and activity of CPEB3. PubMed ID: 26074071

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system. PubMed ID: 9261152