Details for: ALDH3B2

Gene ID: 222

Symbol: ALDH3B2

Ensembl ID: ENSG00000132746

Description: aldehyde dehydrogenase 3 family member B2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 8.6186
    Cell Significance Index: 11.1500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 8.2956
    Cell Significance Index: 172.0900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 3.4817
    Cell Significance Index: 7.8500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 3.3409
    Cell Significance Index: 107.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0323
    Cell Significance Index: 44.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.9124
    Cell Significance Index: 47.8100
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1.7345
    Cell Significance Index: 1.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1950
    Cell Significance Index: 62.0800
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 1.0685
    Cell Significance Index: 1.2300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.7054
    Cell Significance Index: 8.2000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.6661
    Cell Significance Index: -1.4600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5817
    Cell Significance Index: 16.2600
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.4948
    Cell Significance Index: 3.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4817
    Cell Significance Index: 91.6700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3014
    Cell Significance Index: 7.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3007
    Cell Significance Index: 22.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2767
    Cell Significance Index: 16.9700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2539
    Cell Significance Index: 15.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2507
    Cell Significance Index: 3.4200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2373
    Cell Significance Index: 2.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1637
    Cell Significance Index: 72.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1051
    Cell Significance Index: 7.4300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1036
    Cell Significance Index: 11.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0936
    Cell Significance Index: 16.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0546
    Cell Significance Index: 6.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0229
    Cell Significance Index: 1.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0185
    Cell Significance Index: 10.1200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0132
    Cell Significance Index: 11.8900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0074
    Cell Significance Index: 0.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0025
    Cell Significance Index: 0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0090
    Cell Significance Index: -16.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0108
    Cell Significance Index: -19.8800
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0113
    Cell Significance Index: -0.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0127
    Cell Significance Index: -2.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0130
    Cell Significance Index: -20.0300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0147
    Cell Significance Index: -19.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0164
    Cell Significance Index: -12.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0179
    Cell Significance Index: -11.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0189
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0191
    Cell Significance Index: -14.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0225
    Cell Significance Index: -17.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0227
    Cell Significance Index: -1.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0240
    Cell Significance Index: -13.5200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0251
    Cell Significance Index: -0.6700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0262
    Cell Significance Index: -1.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0333
    Cell Significance Index: -15.1000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0389
    Cell Significance Index: -13.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0457
    Cell Significance Index: -13.1400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.0582
    Cell Significance Index: -0.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0589
    Cell Significance Index: -2.0700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0598
    Cell Significance Index: -0.7800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0639
    Cell Significance Index: -1.8400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0659
    Cell Significance Index: -13.0800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0678
    Cell Significance Index: -14.2700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0688
    Cell Significance Index: -0.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0743
    Cell Significance Index: -14.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0765
    Cell Significance Index: -8.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0768
    Cell Significance Index: -11.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0786
    Cell Significance Index: -13.4200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0813
    Cell Significance Index: -1.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0855
    Cell Significance Index: -11.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0863
    Cell Significance Index: -8.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0893
    Cell Significance Index: -4.0500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0918
    Cell Significance Index: -1.5700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0945
    Cell Significance Index: -1.0700
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0950
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0967
    Cell Significance Index: -11.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0993
    Cell Significance Index: -13.6300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1126
    Cell Significance Index: -2.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1152
    Cell Significance Index: -13.5900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1217
    Cell Significance Index: -0.8200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1223
    Cell Significance Index: -1.3400
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -0.1236
    Cell Significance Index: -0.9700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1548
    Cell Significance Index: -12.2600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1607
    Cell Significance Index: -1.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1717
    Cell Significance Index: -17.8800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.1917
    Cell Significance Index: -1.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2158
    Cell Significance Index: -14.5100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2176
    Cell Significance Index: -3.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2240
    Cell Significance Index: -14.1200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2316
    Cell Significance Index: -3.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2334
    Cell Significance Index: -10.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2354
    Cell Significance Index: -14.4700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2434
    Cell Significance Index: -6.0800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2463
    Cell Significance Index: -3.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2518
    Cell Significance Index: -16.2500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2523
    Cell Significance Index: -7.4300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2695
    Cell Significance Index: -3.4700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2763
    Cell Significance Index: -5.8900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3028
    Cell Significance Index: -5.9100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3096
    Cell Significance Index: -7.7200
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.3242
    Cell Significance Index: -3.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3267
    Cell Significance Index: -18.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3413
    Cell Significance Index: -12.5300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3828
    Cell Significance Index: -13.4100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3867
    Cell Significance Index: -9.8800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4571
    Cell Significance Index: -10.5600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4623
    Cell Significance Index: -15.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4685
    Cell Significance Index: -14.9200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.4748
    Cell Significance Index: -7.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ALDH3B2 is a member of the aldehyde dehydrogenase (ALDH) family, which plays a crucial role in detoxifying aldehydes and maintaining cellular redox balance. The enzyme exhibits high specificity for 3-chloroallyl aldehyde and ethanol, indicating its ability to efficiently metabolize these compounds. Additionally, its involvement in the cellular aldehyde metabolic process and lipid droplet formation highlights its role in regulating lipid homeostasis. The gene's expression in various cell types, including immune cells, underscores its importance in maintaining immune function and preventing oxidative stress. **Pathways and Functions:** ALDH3B2 is involved in several key metabolic pathways, including: 1. **Aldehyde Dehydrogenase (NAD+) Activity**: ALDH3B2 catalyzes the conversion of 3-chloroallyl aldehyde to 3-chloroallyl alcohol, thereby protecting cells from oxidative damage. 2. **Alcohol Metabolic Process**: The enzyme participates in the catabolism of ethanol, facilitating its detoxification and metabolism. 3. **Cellular Aldehyde Metabolic Process**: ALDH3B2 plays a crucial role in regulating the levels of aldehydes within cells, which is essential for maintaining cellular homeostasis. 4. **Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (Non-Phosphorylating) Activity**: This activity highlights the enzyme's role in regulating glycolysis and lipid metabolism. 5. **Lipid Droplet Formation**: ALDH3B2 contributes to the formation of lipid droplets, which are essential for lipid storage and metabolism. **Clinical Significance:** The dysregulation of ALDH3B2 has been implicated in various diseases, including: 1. **Alcoholic Liver Disease**: Impaired ALDH3B2 activity has been linked to the development of alcoholic liver disease, highlighting the enzyme's role in protecting the liver from ethanol-induced damage. 2. **Immune System Dysfunction**: ALDH3B2 expression in immune cells suggests its importance in maintaining immune function and preventing oxidative stress. 3. **Cancer**: The enzyme's role in regulating lipid metabolism and cellular homeostasis makes it a potential target for cancer therapy. In conclusion, ALDH3B2 plays a critical role in maintaining cellular homeostasis and immune function through its involvement in aldehyde metabolism and lipid droplet formation. Further investigation into the mechanisms of ALDH3B2 and its dysregulation is essential for understanding the pathogenesis of various diseases and developing novel therapeutic strategies.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.