Genular: Defining Cellular Identity and Function

Details for: Uchl1

Gene ID: 22223

Symbol: Uchl1

Ensembl ID: ENSMUSG00000029223

Description: ubiquitin carboxy-terminal hydrolase L1

Associated with

Deubiquitination
(R-MMU-5688426)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Uch proteinases
(R-MMU-5689603)
Adult walking behavior
(GO:0007628)
Alpha-2a adrenergic receptor binding
(GO:0031694)
Axon
(GO:0030424)
Axonal transport of mitochondrion
(GO:0019896)
Axonogenesis
(GO:0007409)
Axon target recognition
(GO:0007412)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cysteine-type deubiquitinase activity
(GO:0004843)
Cysteine-type endopeptidase activity
(GO:0004197)
Cysteine-type peptidase activity
(GO:0008234)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Eating behavior
(GO:0042755)
Endoplasmic reticulum
(GO:0005783)
Hydrolase activity
(GO:0016787)
Male germ cell proliferation
(GO:0002176)
Membrane
(GO:0016020)
Muscle cell development
(GO:0055001)
Myelin sheath
(GO:0043209)
Negative regulation of map kinase activity
(GO:0043407)
Neuromuscular process
(GO:0050905)
Neuronal cell body
(GO:0043025)
Neuron projection terminus
(GO:0044306)
Nucleoplasm
(GO:0005654)
Omega peptidase activity
(GO:0008242)
Peptidase activity
(GO:0008233)
Plasma membrane
(GO:0005886)
Protein deubiquitination
(GO:0016579)
Proteolysis
(GO:0006508)
Response to ischemia
(GO:0002931)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin binding
(GO:0043130)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Ubiquitin carboxyl-terminal hydrolase isozyme L1

Genular Protein ID: 580288484

Symbol: UCHL1_MOUSE

Name: Ubiquitin carboxyl-terminal hydrolase isozyme L1

UniProtKB Accession Codes:

Q9R0P9 Q9R122

Database IDs:

Citations:

PubMed ID: 10471497

Title: Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice.

PubMed ID: 10471497

DOI: 10.1038/12647

PubMed ID: 12559414

Title: Age-related alterations in the protein expression profile of C57BL/6J mouse pituitaries.

PubMed ID: 12559414

DOI: 10.1016/s0531-5565(02)00117-1

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12913066

Title: Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron.

PubMed ID: 12913066

DOI: 10.1093/hmg/ddg211

PubMed ID: 14695319

Title: Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo.

PubMed ID: 14695319

DOI: 10.1016/s0002-9440(10)63096-9

PubMed ID: 15911766

Title: Replaceable neurons and neurodegenerative disease share depressed UCHL1 levels.

PubMed ID: 15911766

DOI: 10.1073/pnas.0503239102

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 31492742

Title: Deubiquitinating Enzyme UCH-L1 Promotes Dendritic Cell Antigen Cross-Presentation by Favoring Recycling of MHC Class I Molecules.

PubMed ID: 31492742

DOI: 10.4049/jimmunol.1801133

PubMed ID: 32494592

Title: The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor.

PubMed ID: 32494592

DOI: 10.1126/sciadv.aax4826

PubMed ID: 33137160

Title: UCHL1 regulates oxidative activity in skeletal muscle.

PubMed ID: 33137160

DOI: 10.1371/journal.pone.0241716

PubMed ID: 37215988

Title: The deubiquitinase UCHL1 negatively controls osteoclastogenesis by regulating TAZ/NFATC1 signalling.

PubMed ID: 37215988

DOI: 10.7150/ijbs.82152

Sequence Information:

Length: 223
Mass: 24838
Checksum: F1402BF7B0C077EA
Sequence:

MQLKPMEINP EMLNKVLAKL GVAGQWRFAD VLGLEEETLG SVPSPACALL LLFPLTAQHE 
NFRKKQIEEL KGQEVSPKVY FMKQTIGNSC GTIGLIHAVA NNQDKLEFED GSVLKQFLSE 
TEKLSPEDRA KCFEKNEAIQ AAHDSVAQEG QCRVDDKVNF HFILFNNVDG HLYELDGRMP 
FPVNHGASSE DSLLQDAAKV CREFTEREQG EVRFSAVALC KAA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Uchl1

Associated with

Other Information

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice. PubMed ID: 10471497

Age-related alterations in the protein expression profile of C57BL/6J mouse pituitaries. PubMed ID: 12559414

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. PubMed ID: 12913066

Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo. PubMed ID: 14695319

Replaceable neurons and neurodegenerative disease share depressed UCHL1 levels. PubMed ID: 15911766

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Deubiquitinating Enzyme UCH-L1 Promotes Dendritic Cell Antigen Cross-Presentation by Favoring Recycling of MHC Class I Molecules. PubMed ID: 31492742

The deubiquitinase UCHL1 regulates cardiac hypertrophy by stabilizing epidermal growth factor receptor. PubMed ID: 32494592

UCHL1 regulates oxidative activity in skeletal muscle. PubMed ID: 33137160

The deubiquitinase UCHL1 negatively controls osteoclastogenesis by regulating TAZ/NFATC1 signalling. PubMed ID: 37215988