Details for: Ucp1

Gene ID: 22227

Symbol: Ucp1

Ensembl ID: ENSMUSG00000031710

Description: uncoupling protein 1 (mitochondrial, proton carrier)

Associated with

Other Information

Genular Protein ID: 878260516

Symbol: UCP1_MOUSE

Name: N/A

UniProtKB Accession Codes:

P12242

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChEBI 3 ChiTaRS 1 DNASU 1 EMBL 8 Ensembl 1 GO 28 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 3 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 3410843

Title: The mitochondrial uncoupling protein gene. Correlation of exon structure to transmembrane domains.

PubMed ID: 3410843

DOI: 10.1016/s0021-9258(18)37751-2

PubMed ID: 8264627

Title: An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene.

PubMed ID: 8264627

DOI: 10.1128/mcb.14.1.59-67.1994

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9139827

Title: Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese.

PubMed ID: 9139827

DOI: 10.1038/387090a0

PubMed ID: 19187776

Title: UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.

PubMed ID: 19187776

DOI: 10.1016/j.cmet.2008.12.014

PubMed ID: 20416274

Title: The role of UCP 1 in production of reactive oxygen species by mitochondria isolated from brown adipose tissue.

PubMed ID: 20416274

DOI: 10.1016/j.bbabio.2010.04.008

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20466728

Title: Uncoupling protein 1 decreases superoxide production in brown adipose tissue mitochondria.

PubMed ID: 20466728

DOI: 10.1074/jbc.m110.122861

PubMed ID: 23063128

Title: Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria.

PubMed ID: 23063128

DOI: 10.1016/j.cell.2012.09.010

PubMed ID: 25578880

Title: Cold-inducible Zfp516 activates UCP1 transcription to promote browning of white fat and development of brown fat.

PubMed ID: 25578880

DOI: 10.1016/j.molcel.2014.12.005

PubMed ID: 27027295

Title: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.

PubMed ID: 27027295

DOI: 10.1038/nature17399

PubMed ID: 32358195

Title: Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity.

PubMed ID: 32358195

DOI: 10.1073/pnas.2001387117

Sequence Information:

  • Length: 307
  • Mass: 33248
  • Checksum: 33D107EDF04BD1AF
  • Sequence:
    • MVNPTTSEVQ PTMGVKIFSA GVSACLADII TFPLDTAKVR LQIQGEGQAS STIRYKGVLG 
TITTLAKTEG LPKLYSGLPA GIQRQISFAS LRIGLYDSVQ EYFSSGRETP ASLGNKISAG 
LMTGGVAVFI GQPTEVVKVR MQAQSHLHGI KPRYTGTYNA YRVIATTESL STLWKGTTPN 
LMRNVIINCT ELVTYDLMKG ALVNNKILAD DVPCHLLSAL VAGFCTTLLA SPVDVVKTRF 
INSLPGQYPS VPSCAMSMYT KEGPTAFFKG FVASFLRLGS WNVIMFVCFE QLKKELMKSR 
QTVDCTT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.