Details for: Ucp2

Gene ID: 22228

Symbol: Ucp2

Ensembl ID: ENSMUSG00000033685

Description: uncoupling protein 2 (mitochondrial, proton carrier)

Associated with

Other Information

Genular Protein ID: 3372648141

Symbol: UCP2_MOUSE

Name: Mitochondrial uncoupling protein 2

UniProtKB Accession Codes:

P70406 O88285

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChEBI 20 ChiTaRS 1 DNASU 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 3 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 10 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 9133562

Title: Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis.

PubMed ID: 9133562

DOI: 10.2337/diab.46.5.900

PubMed ID: 9710252

Title: Genomic organization and promoter function of the mouse uncoupling protein 2 (UCP2) gene.

PubMed ID: 9710252

DOI: 10.1016/s0014-5793(98)00835-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11101840

Title: Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production.

PubMed ID: 11101840

DOI: 10.1038/82565

PubMed ID: 12011051

Title: No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria.

PubMed ID: 12011051

DOI: 10.1074/jbc.m202535200

PubMed ID: 11756659

Title: A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2.

PubMed ID: 11756659

DOI: 10.1073/pnas.012410699

PubMed ID: 26919426

Title: UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness.

PubMed ID: 26919426

DOI: 10.1016/j.cell.2016.02.010

PubMed ID: 33798544

Title: Mitochondrial proton leaks and uncoupling proteins.

PubMed ID: 33798544

DOI: 10.1016/j.bbabio.2021.148428

PubMed ID: 34644537

Title: IL-33-induced metabolic reprogramming controls the differentiation of alternatively activated macrophages and the resolution of inflammation.

PubMed ID: 34644537

DOI: 10.1016/j.immuni.2021.09.010

PubMed ID: 21785437

Title: Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching.

PubMed ID: 21785437

DOI: 10.1038/nature10257

Sequence Information:

  • Length: 309
  • Mass: 33374
  • Checksum: 329794EEA99810E5
  • Sequence:
    • MVGFKATDVP PTATVKFLGA GTAACIADLI TFPLDTAKVR LQIQGESQGL VRTAASAQYR 
GVLGTILTMV RTEGPRSLYN GLVAGLQRQM SFASVRIGLY DSVKQFYTKG SEHAGIGSRL 
LAGSTTGALA VAVAQPTDVV KVRFQAQARA GGGRRYQSTV EAYKTIAREE GIRGLWKGTS 
PNVARNAIVN CAELVTYDLI KDTLLKANLM TDDLPCHFTS AFGAGFCTTV IASPVDVVKT 
RYMNSALGQY HSAGHCALTM LRKEGPRAFY KGFMPSFLRL GSWNVVMFVT YEQLKRALMA 
AYQSREAPF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.