Genular: Defining Cellular Identity and Function

Details for: Ucp3

Gene ID: 22229

Symbol: Ucp3

Ensembl ID: ENSMUSG00000032942

Description: uncoupling protein 3 (mitochondrial, proton carrier)

Associated with

Metabolism
(R-MMU-1430728)
Mitochondrial uncoupling
(R-MMU-166187)
Respiratory electron transport, atp synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
(R-MMU-163200)
The citric acid (tca) cycle and respiratory electron transport
(R-MMU-1428517)
The fatty acid cycling model
(R-MMU-167826)
The proton buffering model
(R-MMU-167827)
Adaptive thermogenesis
(GO:1990845)
Fatty acid metabolic process
(GO:0006631)
Lipid hydroperoxide transport
(GO:1901373)
Membrane
(GO:0016020)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial membrane
(GO:0031966)
Mitochondrial transmembrane transport
(GO:1990542)
Mitochondrial transport
(GO:0006839)
Mitochondrion
(GO:0005739)
Oxidative phosphorylation uncoupler activity
(GO:0017077)
Protein binding
(GO:0005515)
Proton transmembrane transport
(GO:1902600)
Proton transmembrane transporter activity
(GO:0015078)
Response to cold
(GO:0009409)
Response to hypoxia
(GO:0001666)
Response to superoxide
(GO:0000303)

Other Information

Proteins

Solute carrier family 25 member 9

Genular Protein ID: 875852226

Symbol: UCP3_MOUSE

Name: Solute carrier family 25 member 9

UniProtKB Accession Codes:

P56501 O88293

Database IDs:

Citations:

PubMed ID: 9666083

Title: Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region, and its genetic map.

PubMed ID: 9666083

DOI: 10.1016/s0378-1119(98)00279-0

PubMed ID: 10066417

Title: Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes.

PubMed ID: 10066417

DOI: 10.1006/bbrc.1999.0239

PubMed ID: 9600108

Title: Transcriptional regulation of muscle-specific genes during myoblast differentiation.

PubMed ID: 9600108

DOI: 10.1006/bbrc.1998.8600

PubMed ID: 10748195

Title: Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3.

PubMed ID: 10748195

DOI: 10.1074/jbc.m910177199

PubMed ID: 10748196

Title: Energy metabolism in uncoupling protein 3 gene knockout mice.

PubMed ID: 10748196

DOI: 10.1074/jbc.m910179199

PubMed ID: 11707458

Title: The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3.

PubMed ID: 11707458

DOI: 10.1074/jbc.m109736200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20363757

Title: UCP3 translocates lipid hydroperoxide and mediates lipid hydroperoxide-dependent mitochondrial uncoupling.

PubMed ID: 20363757

DOI: 10.1074/jbc.m110.102699

PubMed ID: 26915802

Title: UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion.

PubMed ID: 26915802

DOI: 10.1016/j.bbrc.2016.02.075

PubMed ID: 29212043

Title: Inhibition of mitochondrial UCP1 and UCP3 by purine nucleotides and phosphate.

PubMed ID: 29212043

DOI: 10.1016/j.bbamem.2017.12.001

Sequence Information:

Length: 308
Mass: 33911
Checksum: 12CAD7674DF7D0C3
Sequence:

MVGLQPSEVP PTTVVKFLGA GTAACFADLL TFPLDTAKVR LQIQGENPGA QSVQYRGVLG 
TILTMVRTEG PRSPYSGLVA GLHRQMSFAS IRIGLYDSVK QFYTPKGADH SSVAIRILAG 
CTTGAMAVTC AQPTDVVKVR FQAMIRLGTG GERKYRGTMD AYRTIAREEG VRGLWKGTWP 
NITRNAIVNC AEMVTYDIIK EKLLESHLFT DNFPCHFVSA FGAGFCATVV ASPVDVVKTR 
YMNAPLGRYR SPLHCMLKMV AQEGPTAFYK GFVPSFLRLG AWNVMMFVTY EQLKRALMKV 
QVLRESPF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ucp3

Associated with

Other Information

Cloning of mouse uncoupling protein 3 cDNA and 5'-flanking region, and its genetic map. PubMed ID: 9666083

Genomic organization and regulation by dietary fat of the uncoupling protein 3 and 2 genes. PubMed ID: 10066417

Transcriptional regulation of muscle-specific genes during myoblast differentiation. PubMed ID: 9600108

Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. PubMed ID: 10748195

Energy metabolism in uncoupling protein 3 gene knockout mice. PubMed ID: 10748196

The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3. PubMed ID: 11707458

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

UCP3 translocates lipid hydroperoxide and mediates lipid hydroperoxide-dependent mitochondrial uncoupling. PubMed ID: 20363757

UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion. PubMed ID: 26915802

Inhibition of mitochondrial UCP1 and UCP3 by purine nucleotides and phosphate. PubMed ID: 29212043