Genular: Defining Cellular Identity and Function

Details for: Umod

Gene ID: 22242

Symbol: Umod

Ensembl ID: ENSMUSG00000030963

Description: uromodulin

Associated with

Asparagine n-linked glycosylation
(R-MMU-446203)
Metabolism of proteins
(R-MMU-392499)
Post-translational protein modification
(R-MMU-597592)
Antibacterial innate immune response
(GO:0140367)
Apical part of cell
(GO:0045177)
Apical plasma membrane
(GO:0016324)
Apoptotic process
(GO:0006915)
Apoptotic signaling pathway
(GO:0097190)
Autophagy
(GO:0006914)
Basolateral plasma membrane
(GO:0016323)
Calcium ion binding
(GO:0005509)
Calcium ion homeostasis
(GO:0055074)
Cell projection
(GO:0042995)
Cell surface
(GO:0009986)
Cellular response to stress
(GO:0033554)
Cellular response to unfolded protein
(GO:0034620)
Chaperone-mediated protein folding
(GO:0061077)
Chemical homeostasis
(GO:0048878)
Chemokine production
(GO:0032602)
Chloride ion homeostasis
(GO:0055064)
Cilium
(GO:0005929)
Citric acid secretion
(GO:0046720)
Collecting duct development
(GO:0072044)
Connective tissue replacement
(GO:0097709)
Defense response to gram-negative bacterium
(GO:0050829)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum organization
(GO:0007029)
Erad pathway
(GO:0036503)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Gene expression
(GO:0010467)
Glomerular filtration
(GO:0003094)
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
(GO:0007157)
Igg binding
(GO:0019864)
Immune system process
(GO:0002376)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Intracellular calcium ion homeostasis
(GO:0006874)
Intracellular chloride ion homeostasis
(GO:0030644)
Intracellular phosphate ion homeostasis
(GO:0030643)
Intracellular sodium ion homeostasis
(GO:0006883)
Juxtaglomerular apparatus development
(GO:0072051)
Kidney development
(GO:0001822)
Leukocyte cell-cell adhesion
(GO:0007159)
Lipid metabolic process
(GO:0006629)
Loop of henle development
(GO:0072070)
Membrane
(GO:0016020)
Metanephric ascending thin limb development
(GO:0072218)
Metanephric distal convoluted tubule development
(GO:0072221)
Metanephric thick ascending limb development
(GO:0072233)
Micturition
(GO:0060073)
Monoatomic ion homeostasis
(GO:0050801)
Multicellular organismal-level homeostasis
(GO:0048871)
Multicellular organismal-level water homeostasis
(GO:0050891)
Multicellular organismal response to stress
(GO:0033555)
Neutrophil migration
(GO:1990266)
Organ or tissue specific immune response
(GO:0002251)
Peptidyl-threonine phosphorylation
(GO:0018107)
Phosphate ion homeostasis
(GO:0055062)
Plasma membrane
(GO:0005886)
Potassium ion homeostasis
(GO:0055075)
Protein binding
(GO:0005515)
Protein localization to vacuole
(GO:0072665)
Protein phosphorylation
(GO:0006468)
Protein transport into plasma membrane raft
(GO:0044861)
Regulation of blood pressure
(GO:0008217)
Regulation of protein transport
(GO:0051223)
Regulation of urine volume
(GO:0035809)
Renal sodium ion absorption
(GO:0070294)
Renal urate salt excretion
(GO:0097744)
Renal water homeostasis
(GO:0003091)
Response to diuretic
(GO:0036270)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to lipopolysaccharide
(GO:0032496)
Response to unfolded protein
(GO:0006986)
Response to water deprivation
(GO:0009414)
Response to xenobiotic stimulus
(GO:0009410)
Rna splicing
(GO:0008380)
Side of membrane
(GO:0098552)
Sodium ion homeostasis
(GO:0055078)
Spindle pole
(GO:0000922)
Tumor necrosis factor-mediated signaling pathway
(GO:0033209)
Urate transport
(GO:0015747)
Urea transmembrane transport
(GO:0071918)

Other Information

Proteins

Uromodulin

Genular Protein ID: 2977824058

Symbol: UROM_MOUSE

Name: Uromodulin

UniProtKB Accession Codes:

Q91X17 Q3TN64 Q3TP60 Q62285

Database IDs:

Citations:

PubMed ID: 7873609

Title: Nucleotide sequence and peptide motifs of mouse uromodulin (Tamm-Horsfall protein) -- the most abundant protein in mammalian urine.

PubMed ID: 7873609

DOI: 10.1016/0167-4781(94)00240-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11134021

Title: Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors.

PubMed ID: 11134021

DOI: 10.1074/jbc.m008610200

PubMed ID: 12021773

Title: The ZP domain is a conserved module for polymerization of extracellular proteins.

PubMed ID: 12021773

DOI: 10.1038/ncb802

PubMed ID: 14871399

Title: Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication.

PubMed ID: 14871399

DOI: 10.1111/j.1523-1755.2004.00452.x

PubMed ID: 15327412

Title: Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation.

PubMed ID: 15327412

DOI: 10.1111/j.1523-1755.2004.00867.x

PubMed ID: 18375198

Title: Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage.

PubMed ID: 18375198

DOI: 10.1016/j.bbrc.2008.03.099

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 26673890

Title: The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin.

PubMed ID: 26673890

DOI: 10.7554/elife.08887

Sequence Information:

Length: 642
Mass: 70845
Checksum: 31B1461B4DCAE927
Sequence:

MGIPLTWMLL VMMVTSWFTL AEASNSTEAR RCSECHNNAT CTVDGVVTTC SCQTGFTGDG 
LVCEDMDECA TPWTHNCSNS SCVNTPGSFK CSCQDGFRLT PELSCTDVDE CSEQGLSNCH 
ALATCVNTEG DYLCVCPEGF TGDGWYCECS PGSCEPGLDC LPQGPDGKLV CQDPCNTYET 
LTEYWRSTEY GVGYSCDAGL HGWYRFTGQG GVRMAETCVP VLRCNTAAPM WLNGSHPSSS 
EGIVSRTACA HWSDQCCRWS TEIQVKACPG GFYIYNLTAP PECNLAYCTD PSSVEGTCEE 
CRVDEDCISD NGRWRCQCKQ DSNITDVSQL EYRLECGAND IKMSLRKCQL QSLGFMNVFM 
YLNDRQCSGF SESDERDWMS IVTPARNGPC GTVLRRNETH ATYSNTLYLA NAIIIRDIII 
RMNFECSYPL DMKVSLKTSL QPMVSALNIS LGGTGKFTVR MALFQSPTYT QPHQGPSVML 
STEAFLYVGT MLDGGDLSRF VLLMTNCYAT PSSNSTDPVK YFIIQDSCPR TEDTTIQVTE 
NGESSQARFS VQMFRFAGNY DLVYLHCEVY LCDSTSEQCK PTCSGTRFRS GNFIDQTRVL 
NLGPITRQGV QASVSKAASS NLRLLSIWLL LFPSATLIFM VQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Umod

Associated with

Other Information

Nucleotide sequence and peptide motifs of mouse uromodulin (Tamm-Horsfall protein) -- the most abundant protein in mammalian urine. PubMed ID: 7873609

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E. coli from binding to uroplakin Ia and Ib receptors. PubMed ID: 11134021

The ZP domain is a conserved module for polymerization of extracellular proteins. PubMed ID: 12021773

Tamm-Horsfall protein knockout mice are more prone to urinary tract infection: rapid communication. PubMed ID: 14871399

Tamm-Horsfall protein is a critical renal defense factor protecting against calcium oxalate crystal formation. PubMed ID: 15327412

Urinary uromodulin carries an intact ZP domain generated by a conserved C-terminal proteolytic cleavage. PubMed ID: 18375198

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin. PubMed ID: 26673890