Details for: Unc5c

Gene ID: 22253

Symbol: Unc5c

Ensembl ID: ENSMUSG00000059921

Description: unc-5 netrin receptor C

Associated with

Other Information

Genular Protein ID: 2303265960

Symbol: UNC5C_MOUSE

Name: Netrin receptor UNC5C

UniProtKB Accession Codes:

O08747 Q8CD16

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 3 ExpressionAtlas 1 GO 26 Gene3D 4 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 14 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PaxDb 1 Pfam 5 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SMART 5 SMR 1 STRING 1 SUPFAM 3 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9126743

Title: The mouse rostral cerebellar malformation gene encodes an UNC-5-like protein.

PubMed ID: 9126743

DOI: 10.1038/386838a0

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 9389662

Title: Embryonic phenotype of Unc5h3 mutant mice suggests chemorepulsion during the formation of the rostral cerebellar boundary.

PubMed ID: 9389662

DOI: 10.1242/dev.125.1.41

PubMed ID: 10399920

Title: A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion.

PubMed ID: 10399920

DOI: 10.1016/s0092-8674(00)80804-1

PubMed ID: 11533026

Title: Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.

PubMed ID: 11533026

DOI: 10.1074/jbc.m103872200

PubMed ID: 12451134

Title: The netrin 1 receptors Unc5h3 and Dcc are necessary at multiple choice points for the guidance of corticospinal tract axons.

PubMed ID: 12451134

DOI: 10.1523/jneurosci.22-23-10346.2002

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22685302

Title: Down syndrome cell adhesion molecule (DSCAM) associates with uncoordinated-5C (UNC5C) in netrin-1-mediated growth cone collapse.

PubMed ID: 22685302

DOI: 10.1074/jbc.m112.340174

PubMed ID: 22405201

Title: FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development.

PubMed ID: 22405201

DOI: 10.1016/j.neuron.2012.01.018

PubMed ID: 25419706

Title: A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death.

PubMed ID: 25419706

DOI: 10.1038/nm.3736

PubMed ID: 28483977

Title: Uncoupling of UNC5C with Polymerized TUBB3 in Microtubules Mediates Netrin-1 Repulsion.

PubMed ID: 28483977

DOI: 10.1523/jneurosci.2617-16.2017

Sequence Information:

  • Length: 931
  • Mass: 103063
  • Checksum: 8A5D951A4EECA179
  • Sequence:
    • MRKGLRATAA RCGLGLGYLL QMLVLPALAL LSASGTGSAA QDDEFFHELP ETFPSDPPEP 
LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHVVDER VDETSGLIVR 
EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL 
EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP AEDRNFYITI DHNLIIKQAR LSDTANYTCV 
AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE 
GQSVQKIACT TLCPVDGRWT SWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK 
NCTDGLCMQA APDSDDVALY VGIVIAVTVC LAITVVVALF VYRKNHRDFE SDIIDSSALN 
GGFQPVNIKA ARQDLLAVPP DLTSAAAMYR GPVYALHDVS DKIPMTNSPI LDPLPNLKIK 
VYNSSGAVTP QDDLAEFSSK LSPQMTQSLL ENEALNLKNQ SLARQTDPSC TAFGTFNSLG 
GHLIIPNSGV SLLIPAGAIP QGRVYEMYVT VHRKENMRPP MEDSQTLLTP VVSCGPPGAL 
LTRPVILTLH HCADPSTEDW KIQLKNQAVQ GQWEDVVVVG EENFTTPCYI QLDAEACHIL 
TENLSTYALV GQSTTKAAAK RLKLAIFGPL CCSSLEYSIR VYCLDDTQDA LKEVLQLERQ 
MGGQLLEEPK ALHFKGSIHN LRLSIHDIAH SLWKSKLLAK YQEIPFYHIW SGSQRNLHCT 
FTLERLSLNT VELVCKLCVR QVEGEGQIFQ LNCTVSEEPT GIDLPLLDPA STITTVTGPS 
AFSIPLPIRQ KLCSSLDAPQ TRGHDWRMLA HKLNLDRYLN YFATKSSPTG VILDLWEAQN 
FPDGNLSMLA AVLEEMGRHE TVVSLAAEGQ Y

Genular Protein ID: 3759559103

Symbol: Q3URW2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3URW2

Database IDs:

AGR 1 ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 4 InterPro 14 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 Pfam 5 RefSeq 1 RuleBase 1 SAM 1 SMART 5 SUPFAM 3

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 950
  • Mass: 105245
  • Checksum: 20A6A83359A36503
  • Sequence:
    • MRKGLRATAA RCGLGLGYLL QMLVLPALAL LSASGTGSAA QDDEFFHELP ETFPSDPPEP 
LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHVVDER VDETSGLIVR 
EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL 
EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP AEDRNFYITI DHNLIIKQAR LSDTANYTCV 
AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE 
GQSVQKIACT TLCPVGGRWT SWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK 
NCTDGLCMQG FIYPISTEHR PQNEYGFSSA PDSDDVALYV GIVIAVTVCL AITVVVALFV 
YRKNHRDFES DIIDSSALNG GFQPVNIKAA RQDLLAVPPD LTSAAAMYRG PVYALHDVSD 
KIPMTNSPIL DPLPNLKIKV YNSSGAVTPQ DDLAEFSSKL SPQMTQSLLE NEALNLKNQS 
LARQTDPSCT AFGTFNSLGG HLIIPNSGVS LLIPAGAIPQ GRVYEMYVTV HRKENMRPPM 
EDSQTLLTPV VSCGPPGALL TRPVILTLHH CADPSTEDWK IQLKNQAVQG QWEDVVVVGE 
ENFTTPCYIQ LDAEACHILT ENLSTYALVG QSTTKAAAKR LKLAIFGPLC CSSLEYSIRV 
YCLDDTQDAL KEVLQLERQM GGQLLEEPKA LHFKGSIHNL RLSIHDIAHS LWKSKLLAKY 
QEIPFYHIWS GSQRNLHCTF TLERLSLNTV ELVCKLCVRQ VEGEGQIFQL NCTVSEEPTG 
IDLPLLDPAS TITTVTGPSA FSIPLPIRQK LCSSLDAPQT RGHDWRMLAH KLNLDRYLNY 
FATKSSPTGV ILDLWEAQNF PDGNLSMLAA VLEEMGRHET VVSLAAEGQY

Genular Protein ID: 564846539

Symbol: Q3UQ08_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UQ08

Database IDs:

AGR 1 ARBA 10 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 ExpressionAtlas 1 GO 7 Gene3D 4 InterPro 14 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 5 Pfam 5 RefSeq 1 RuleBase 1 SAM 1 SMART 5 SMR 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 950
  • Mass: 105303
  • Checksum: 2074B4BCE6FEC603
  • Sequence:
    • MRKGLRATAA RCGLGLGYLL QMLVLPALAL LSASGTGSAA QDDEFFHELP ETFPSDPPEP 
LPHFLIEPEE AYIVKNKPVN LYCKASPATQ IYFKCNSEWV HQKDHVVDER VDETSGLIVR 
EVSIEISRQQ VEELFGPEDY WCQCVAWSSA GTTKSRKAYV RIAYLRKTFE QEPLGKEVSL 
EQEVLLQCRP PEGIPVAEVE WLKNEDIIDP AEDRNFYITI DHNLIIKQAR LSDTANYTCV 
AKNIVAKRKS TTATVIVYVN GGWSTWTEWS VCNSRCGRGY QKRTRTCTNP APLNGGAFCE 
GQSVQKIACT TLCPVDGRWT SWSKWSTCGT ECTHWRRREC TAPAPKNGGK DCDGLVLQSK 
NCTDGLCMQG FIYPISTEHR PQNEYGFSSA PDSDDVALYV GIVIAVTVCL AITVVVALFV 
YRKNHRDFES DIIDSSALNG GFQPVNIKAA RQDLLAVPPD LTSAAAMYRG PVYALHDVSD 
KIPMTNSPIL DPLPNLKIKV YNSSGAVTPQ DDLAEFSSKL SPQMTQSLLE NEALNLKNQS 
LARQTDPSCT AFGTFNSLGG HLIIPNSGVS LLIPAGAIPQ GRVYEMYVTV HRKENMRPPM 
EDSQTLLTPV VSCGPPGALL TRPVILTLHH CADPSTEDWK IQLKNQAVQG QWEDVVVVGE 
ENFTTPCYIQ LDAEACHILT ENLSTYALVG QSTTKAAAKR LKLAIFGPLC CSSLEYSIRV 
YCLDDTQDAL KEVLQLERQM GGQLLEEPKA LHFKGSIHNL RLSIHDIAHS LWKSKLLAKY 
QEIPFYHIWS GSQRNLHCTF TLERLSLNTV ELVCKLCVRQ VEGEGQIFQL NCTVSEEPTG 
IDLPLLDPAS TITTVTGPSA FSIPLPIRQK LCSSLDAPQT RGHDWRMLAH KLNLDRYLNY 
FATKSSPTGV ILDLWEAQNF PDGNLSMLAA VLEEMGRHET VVSLAAEGQY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.