Genular: Defining Cellular Identity and Function

Details for: Uncx

Gene ID: 22255

Symbol: Uncx

Ensembl ID: ENSMUSG00000029546

Description: UNC homeobox

Associated with

Cartilage condensation
(GO:0001502)
Cell differentiation
(GO:0030154)
Common myeloid progenitor cell proliferation
(GO:0035726)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Dorsal spinal cord development
(GO:0021516)
Multicellular organism development
(GO:0007275)
Nervous system development
(GO:0007399)
Nucleus
(GO:0005634)
Olfactory bulb interneuron differentiation
(GO:0021889)
Pattern specification process
(GO:0007389)
Regulation of cell differentiation
(GO:0045595)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Sequence-specific double-stranded dna binding
(GO:1990837)

Other Information

Proteins

Homeobox protein unc-4 homolog

Genular Protein ID: 4043232859

Symbol: UNC4_MOUSE

Name: Homeobox protein unc-4 homolog

UniProtKB Accession Codes:

O08934 P70457 Q78DU3

Database IDs:

Citations:

PubMed ID: 10804169

Title: The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column.

PubMed ID: 10804169

DOI: 10.1242/dev.127.11.2259

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9286595

Title: Paired-related murine homeobox gene expressed in the developing sclerotome, kidney, and nervous system.

PubMed ID: 9286595

DOI: 10.1002/(sici)1097-0177(199709)210:1<53::aid-aja6>3.0.co;2-0

PubMed ID: 8855241

Title: Cloning and characterization of four murine homeobox genes.

PubMed ID: 8855241

DOI: 10.1073/pnas.93.20.10691

PubMed ID: 10330372

Title: Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse.

PubMed ID: 10330372

DOI: 10.1016/s0960-9822(99)80212-7

PubMed ID: 10545229

Title: Adhesive subdivisions intrinsic to the epithelial somites.

PubMed ID: 10545229

DOI: 10.1006/dbio.1999.9463

PubMed ID: 10804168

Title: Uncx4.1 is required for the formation of the pedicles and proximal ribs and acts upstream of Pax9.

PubMed ID: 10804168

DOI: 10.1242/dev.127.11.2251

PubMed ID: 11747084

Title: Early mesodermal phenotypes in splotch suggest a role for Pax3 in the formation of epithelial somites.

PubMed ID: 11747084

DOI: 10.1002/dvdy.1211

PubMed ID: 11973278

Title: Hypomorphic Mesp allele distinguishes establishment of rostrocaudal polarity and segment border formation in somitogenesis.

PubMed ID: 11973278

DOI: 10.1242/dev.129.10.2473

PubMed ID: 16728472

Title: Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2.

PubMed ID: 16728472

DOI: 10.1242/dev.02422

PubMed ID: 16461927

Title: Neurohypophysial dysmorphogenesis in mice lacking the homeobox gene Uncx4.1.

PubMed ID: 16461927

DOI: 10.1677/jme.1.01831

PubMed ID: 17477400

Title: Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formation.

PubMed ID: 17477400

DOI: 10.1002/dvdy.21178

PubMed ID: 17531978

Title: Ripply2 is essential for precise somite formation during mouse early development.

PubMed ID: 17531978

DOI: 10.1016/j.febslet.2007.05.017

Sequence Information:

Length: 530
Mass: 53936
Checksum: 2E3A4DE98428E381
Sequence:

MMDGRLLEHP HAQFGGSLGG VVGFPYPLGH HHVYELAGHQ LQSAAAAAAA ASVPFSIDGL 
LSGSCAAAAA SVVNPTPLLP AACGVAGESQ PFKLADSGDP DKESPGCKRR RTRTNFTGWQ 
LEELEKAFNE SHYPDVFMRE ALALRLDLVE SRVQVWFQNR RAKWRKKENT KKGPGRPAHN 
SHPTTCSGEP MDPEEIARKE LEKMEKKKRK HEKKLLKSQS RHLHSPGGLS LHSAPSSDSD 
SGGGGLSPEP PEPPPPTAAA KGPGAHGSGI AGSAPVPPGE PPAPGTCDPA FYPSQRSGAG 
SQPRLGRPAD KDTVPCGPGA AATAGLPKAS PFSVESLLSD SPPRRKATPA NAAATAGLDF 
TPGLPCAPRT LIGKGHFLLY PITQPLGFLV PQAALKGGAG PELVPKDAPP APPAPPAPPA 
QASFGTFPGP GGAADPAFAR RSPEVVASPG PPAPASFRDL TAAAAESGAG DCADVGTVCP 
AASPPPPLET SPGPGPRAPS PPGEPATCGA AEPGAATGPS PPEGEEVDMD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Uncx

Associated with

Other Information

The paired homeobox gene Uncx4.1 specifies pedicles, transverse processes and proximal ribs of the vertebral column. PubMed ID: 10804169

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Paired-related murine homeobox gene expressed in the developing sclerotome, kidney, and nervous system. PubMed ID: 9286595

Cloning and characterization of four murine homeobox genes. PubMed ID: 8855241

Interaction between Notch signalling and Lunatic fringe during somite boundary formation in the mouse. PubMed ID: 10330372

Adhesive subdivisions intrinsic to the epithelial somites. PubMed ID: 10545229

Uncx4.1 is required for the formation of the pedicles and proximal ribs and acts upstream of Pax9. PubMed ID: 10804168

Early mesodermal phenotypes in splotch suggest a role for Pax3 in the formation of epithelial somites. PubMed ID: 11747084

Hypomorphic Mesp allele distinguishes establishment of rostrocaudal polarity and segment border formation in somitogenesis. PubMed ID: 11973278

Identification of Epha4 enhancer required for segmental expression and the regulation by Mesp2. PubMed ID: 16728472

Neurohypophysial dysmorphogenesis in mice lacking the homeobox gene Uncx4.1. PubMed ID: 16461927

Transcription factors Mesp2 and Paraxis have critical roles in axial musculoskeletal formation. PubMed ID: 17477400

Ripply2 is essential for precise somite formation during mouse early development. PubMed ID: 17531978