Genular: Defining Cellular Identity and Function

Details for: Nr1h3

Gene ID: 22259

Symbol: Nr1h3

Ensembl ID: ENSMUSG00000002108

Description: nuclear receptor subfamily 1, group H, member 3

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Nr1h2 & nr1h3 regulate gene expression to control bile acid homeostasis
(R-MMU-9623433)
Nr1h2 and nr1h3-mediated signaling
(R-MMU-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-MMU-9029569)
Nuclear receptor transcription pathway
(R-MMU-383280)
Plasma lipoprotein assembly, remodeling, and clearance
(R-MMU-174824)
Plasma lipoprotein clearance
(R-MMU-8964043)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by nuclear receptors
(R-MMU-9006931)
Signal transduction
(R-MMU-162582)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of intracellular receptors
(R-MMU-4090294)
Transport of small molecules
(R-MMU-382551)
Vldlr internalisation and degradation
(R-MMU-8866427)
Apoptotic cell clearance
(GO:0043277)
Cell differentiation
(GO:0030154)
Cellular lipid metabolic process
(GO:0044255)
Cellular response to lipopolysaccharide
(GO:0071222)
Cholesterol homeostasis
(GO:0042632)
Chromatin
(GO:0000785)
Chromatin dna binding
(GO:0031490)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna binding
(GO:0003677)
Fatty acid biosynthetic process
(GO:0006633)
Hormone-mediated signaling pathway
(GO:0009755)
Lipid homeostasis
(GO:0055088)
Lipid metabolic process
(GO:0006629)
Metal ion binding
(GO:0046872)
Mrna transcription by rna polymerase ii
(GO:0042789)
Negative regulation of cholesterol storage
(GO:0010887)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of lipid transport
(GO:0032369)
Negative regulation of macrophage activation
(GO:0043031)
Negative regulation of pancreatic juice secretion
(GO:0090188)
Negative regulation of pinocytosis
(GO:0048550)
Negative regulation of proteolysis
(GO:0045861)
Negative regulation of response to endoplasmic reticulum stress
(GO:1903573)
Negative regulation of secretion of lysosomal enzymes
(GO:0090341)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear receptor activity
(GO:0004879)
Nuclear retinoid x receptor binding
(GO:0046965)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphatidylcholine acyl-chain remodeling
(GO:0036151)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of cholesterol transport
(GO:0032376)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fatty acid biosynthetic process
(GO:0045723)
Positive regulation of lipid biosynthetic process
(GO:0046889)
Positive regulation of lipoprotein lipase activity
(GO:0051006)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of toll-like receptor 4 signaling pathway
(GO:0034145)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of triglyceride biosynthetic process
(GO:0010867)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of fatty acid metabolic process
(GO:0019217)
Response to progesterone
(GO:0032570)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sequence-specific dna binding
(GO:0043565)
Sterol homeostasis
(GO:0055092)
Sterol response element binding
(GO:0032810)
Transcription cis-regulatory region binding
(GO:0000976)
Triglyceride homeostasis
(GO:0070328)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Oxysterols receptor LXR-alpha

Genular Protein ID: 2436871799

Symbol: NR1H3_MOUSE

Name: Oxysterols receptor LXR-alpha

UniProtKB Accession Codes:

Q9Z0Y9 Q9QUH7

Database IDs:

Citations:

PubMed ID: 10675617

Title: Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta.

PubMed ID: 10675617

DOI: 10.1016/s0378-1119(99)00555-7

PubMed ID: 10890879

Title: LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression.

PubMed ID: 10890879

DOI: 10.1073/pnas.100519097

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 18055760

Title: Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3).

PubMed ID: 18055760

DOI: 10.1124/mol.107.040741

PubMed ID: 19520913

Title: LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.

PubMed ID: 19520913

DOI: 10.1126/science.1168974

PubMed ID: 20427281

Title: The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.

PubMed ID: 20427281

DOI: 10.1074/jbc.m110.123729

PubMed ID: 24206663

Title: LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition.

PubMed ID: 24206663

DOI: 10.1016/j.cmet.2013.10.002

PubMed ID: 25806685

Title: Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion.

PubMed ID: 25806685

DOI: 10.7554/elife.06557

PubMed ID: 27383786

Title: TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis.

PubMed ID: 27383786

DOI: 10.1038/nature18628

PubMed ID: 28846071

Title: ER phospholipid composition modulates lipogenesis during feeding and in obesity.

PubMed ID: 28846071

DOI: 10.1172/jci93616

PubMed ID: 16107141

Title: Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.

PubMed ID: 16107141

DOI: 10.1021/jm050532w

PubMed ID: 18800767

Title: Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.

PubMed ID: 18800767

DOI: 10.1021/jm800612u

PubMed ID: 19167885

Title: Synthesis and SAR of potent LXR agonists containing an indole pharmacophore.

PubMed ID: 19167885

DOI: 10.1016/j.bmcl.2009.01.004

Sequence Information:

Length: 445
Mass: 50418
Checksum: 1A426DF38D935731
Sequence:

MSLWLEASMP DVSPDSATEL WKTEPQDAGD QGGNTCILRE EARMPQSTGV ALGIGLESAE 
PTALLPRAET LPEPTELRPQ KRKKGPAPKM LGNELCSVCG DKASGFHYNV LSCEGCKGFF 
RRSVIKGARY VCHSGGHCPM DTYMRRKCQE CRLRKCRQAG MREECVLSEE QIRLKKLKRQ 
EEEQAQATSV SPRVSSPPQV LPQLSPEQLG MIEKLVAAQQ QCNRRSFSDR LRVTPWPIAP 
DPQSREARQQ RFAHFTELAI VSVQEIVDFA KQLPGFLQLS REDQIALLKT SAIEVMLLET 
SRRYNPGSES ITFLKDFSYN REDFAKAGLQ VEFINPIFEF SRAMNELQLN DAEFALLIAI 
SIFSADRPNV QDQLQVERLQ HTYVEALHAY VSINHPHDPL MFPRMLMKLV SLRTLSSVHS 
EQVFALRLQD KKLPPLLSEI WDVHE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nr1h3

Associated with

Other Information

Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta. PubMed ID: 10675617

LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression. PubMed ID: 10890879

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). PubMed ID: 18055760

LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. PubMed ID: 19520913

The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. PubMed ID: 20427281

LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. PubMed ID: 24206663

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. PubMed ID: 25806685

TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis. PubMed ID: 27383786

ER phospholipid composition modulates lipogenesis during feeding and in obesity. PubMed ID: 28846071

Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure. PubMed ID: 16107141

Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. PubMed ID: 18800767

Synthesis and SAR of potent LXR agonists containing an indole pharmacophore. PubMed ID: 19167885