Genular: Defining Cellular Identity and Function

Details for: Nr1h2

Gene ID: 22260

Symbol: Nr1h2

Ensembl ID: ENSMUSG00000060601

Description: nuclear receptor subfamily 1, group H, member 2

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Nr1h2 & nr1h3 regulate gene expression to control bile acid homeostasis
(R-MMU-9623433)
Nr1h2 and nr1h3-mediated signaling
(R-MMU-9024446)
Nr1h3 & nr1h2 regulate gene expression linked to cholesterol transport and efflux
(R-MMU-9029569)
Nuclear receptor transcription pathway
(R-MMU-383280)
Plasma lipoprotein assembly, remodeling, and clearance
(R-MMU-174824)
Plasma lipoprotein clearance
(R-MMU-8964043)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by nuclear receptors
(R-MMU-9006931)
Signal transduction
(R-MMU-162582)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of intracellular receptors
(R-MMU-4090294)
Transport of small molecules
(R-MMU-382551)
Vldlr internalisation and degradation
(R-MMU-8866427)
Apolipoprotein a-i receptor binding
(GO:0034191)
Atpase binding
(GO:0051117)
Cell differentiation
(GO:0030154)
Cellular lipid metabolic process
(GO:0044255)
Cholesterol homeostasis
(GO:0042632)
Chromatin dna binding
(GO:0031490)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Lipid homeostasis
(GO:0055088)
Lipid metabolic process
(GO:0006629)
Metal ion binding
(GO:0046872)
Negative regulation of cholesterol storage
(GO:0010887)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of lipid transport
(GO:0032369)
Negative regulation of pinocytosis
(GO:0048550)
Negative regulation of proteolysis
(GO:0045861)
Negative regulation of response to endoplasmic reticulum stress
(GO:1903573)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear receptor activity
(GO:0004879)
Nuclear retinoid x receptor binding
(GO:0046965)
Nucleus
(GO:0005634)
Phosphatidylcholine acyl-chain remodeling
(GO:0036151)
Positive regulation of cholesterol efflux
(GO:0010875)
Positive regulation of cholesterol transport
(GO:0032376)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of fatty acid biosynthetic process
(GO:0045723)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of high-density lipoprotein particle assembly
(GO:0090108)
Positive regulation of lipid storage
(GO:0010884)
Positive regulation of lipoprotein lipase activity
(GO:0051006)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of pancreatic juice secretion
(GO:0090187)
Positive regulation of protein metabolic process
(GO:0051247)
Positive regulation of secretion of lysosomal enzymes
(GO:0090340)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of triglyceride biosynthetic process
(GO:0010867)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Retinoic acid receptor signaling pathway
(GO:0048384)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sequence-specific dna binding
(GO:0043565)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Oxysterols receptor LXR-beta
Q8BP65_MOUSE

Genular Protein ID: 660896204

Symbol: NR1H2_MOUSE

Name: Oxysterols receptor LXR-beta

UniProtKB Accession Codes:

Q60644

Database IDs:

Citations:

PubMed ID: 7760852

Title: Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors.

PubMed ID: 7760852

DOI: 10.1210/mend.9.1.7760852

PubMed ID: 10675617

Title: Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta.

PubMed ID: 10675617

DOI: 10.1016/s0378-1119(99)00555-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18055760

Title: Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3).

PubMed ID: 18055760

DOI: 10.1124/mol.107.040741

PubMed ID: 19520913

Title: LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor.

PubMed ID: 19520913

DOI: 10.1126/science.1168974

PubMed ID: 20427281

Title: The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2.

PubMed ID: 20427281

DOI: 10.1074/jbc.m110.123729

PubMed ID: 24206663

Title: LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition.

PubMed ID: 24206663

DOI: 10.1016/j.cmet.2013.10.002

PubMed ID: 25806685

Title: Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion.

PubMed ID: 25806685

DOI: 10.7554/elife.06557

PubMed ID: 28846071

Title: ER phospholipid composition modulates lipogenesis during feeding and in obesity.

PubMed ID: 28846071

DOI: 10.1172/jci93616

Sequence Information:

Length: 446
Mass: 49720
Checksum: 73153E635302C9DF
Sequence:

MSSPTSSLDT PVPGNGSPQP STSATSPTIK EEGQETDPPP GSEGSSSAYI VVILEPEDEP 
ERKRKKGPAP KMLGHELCRV CGDKASGFHY NVLSCEGCKG FFRRSVVHGG AGRYACRGSG 
TCQMDAFMRR KCQLCRLRKC KEAGMREQCV LSEEQIRKKR IQKQQQQQPP PPSEPAASSS 
GRPAASPGTS EASSQGSGEG EGIQLTAAQE LMIQQLVAAQ LQCNKRSFSD QPKVTPWPLG 
ADPQSRDARQ QRFAHFTELA IISVQEIVDF AKQVPGFLQL GREDQIALLK ASTIEIMLLE 
TARRYNHETE CITFLKDFTY SKDDFHRAGL QVEFINPIFE FSRAMRRLGL DDAEYALLIA 
INIFSADRPN VQEPSRVEAL QQPYVEALLS YTRIKRPQDQ LRFPRMLMKL VSLRTLSSVH 
SEQVFALRLQ DKKLPPLLSE IWDVHE

Genular Protein ID: 3128902207

Symbol: Q8BP65_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BP65

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 443
Mass: 49394
Checksum: 362DCB2D21034F29
Sequence:

MSSPTSSLDT PVPGNGSPQP STSATSPTIK EEGQETDPPP GSEGSSSAYI VEPEDEPERK 
RKKGPAPKML GHELCRVCGD KASGFHYNVL SCEGCKGFFR RSVVHGGAGR YACRGSGTCQ 
MDAFMRRKCQ LCRLRKCKEA GMREQCVLSE EQIRKKRIQK QQQQQPPPPS EPAASSSGRP 
AASPGTSEAS SQGSGEGEGI QLTAAQELMI QQLVAAQLQC NKRSFSDQPK VTPWPLGADP 
QSRDARQQRF AHFTELAIIS VQEIVDFAKQ VPGFLQLGRE DQIALLKAST IEIMLLETAR 
RYNHETECIT FLKDFTYSKD DFHRAGLQVE FINPIFEFSR AMRRLGLDDA EYALLIAINI 
FSADRPNVQE PSRVEALQQP YVEALLSYTR IKRPQDQLRF PRMLMKLVSL RTLSSVHSEQ 
VFALRLQDKK LPPLLSEIWD VHE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nr1h2

Associated with

Other Information

Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. PubMed ID: 7760852

Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta. PubMed ID: 10675617

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). PubMed ID: 18055760

LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. PubMed ID: 19520913

The E3 ubiquitin ligase IDOL induces the degradation of the low density lipoprotein receptor family members VLDLR and ApoER2. PubMed ID: 20427281

LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. PubMed ID: 24206663

Lpcat3-dependent production of arachidonoyl phospholipids is a key determinant of triglyceride secretion. PubMed ID: 25806685

ER phospholipid composition modulates lipogenesis during feeding and in obesity. PubMed ID: 28846071

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303