Details for: ALDH9A1

Gene ID: 223

Symbol: ALDH9A1

Ensembl ID: ENSG00000143149

Description: aldehyde dehydrogenase 9 family member A1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.17
    Marker Score: 18668
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.91
    Marker Score: 4343
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.88
    Marker Score: 14708.5
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.85
    Marker Score: 7172
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.77
    Marker Score: 10483.5
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.66
    Marker Score: 2298
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.65
    Marker Score: 1774
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.65
    Marker Score: 7099
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.53
    Marker Score: 9968
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.53
    Marker Score: 4159
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.5
    Marker Score: 5318
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.46
    Marker Score: 2389
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.43
    Marker Score: 14404.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.43
    Marker Score: 412
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.39
    Marker Score: 1741
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.37
    Marker Score: 912
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.35
    Marker Score: 3414
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.35
    Marker Score: 2393
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.35
    Marker Score: 502
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.35
    Marker Score: 537
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.34
    Marker Score: 1419
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.32
    Marker Score: 1104
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.31
    Marker Score: 4855
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.31
    Marker Score: 3512
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.31
    Marker Score: 2728
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.3
    Marker Score: 413
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.3
    Marker Score: 1190
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.24
    Marker Score: 1783
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.24
    Marker Score: 2936
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.23
    Marker Score: 355
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.22
    Marker Score: 286
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.22
    Marker Score: 4185
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.21
    Marker Score: 1285
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.21
    Marker Score: 362
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.2
    Marker Score: 698
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.2
    Marker Score: 13895
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.19
    Marker Score: 13361
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.18
    Marker Score: 1229
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.17
    Marker Score: 5594.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.14
    Marker Score: 1145
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.14
    Marker Score: 1686
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.14
    Marker Score: 2995
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.14
    Marker Score: 39594
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.13
    Marker Score: 9859
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.13
    Marker Score: 1805
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.13
    Marker Score: 529
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.12
    Marker Score: 879
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.12
    Marker Score: 4383
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.11
    Marker Score: 1835
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.11
    Marker Score: 28308
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.1
    Marker Score: 1870
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.1
    Marker Score: 252
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.09
    Marker Score: 269.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.09
    Marker Score: 8102
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.09
    Marker Score: 2174
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.09
    Marker Score: 2462.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.07
    Marker Score: 590
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.07
    Marker Score: 715
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.07
    Marker Score: 1318
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.06
    Marker Score: 1074
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.05
    Marker Score: 1689
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.05
    Marker Score: 18605
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.04
    Marker Score: 742
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.03
    Marker Score: 3969
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.03
    Marker Score: 968
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 1.03
    Marker Score: 375
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.01
    Marker Score: 1075
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.01
    Marker Score: 1985
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.01
    Marker Score: 347
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1
    Marker Score: 1054
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1
    Marker Score: 419
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1
    Marker Score: 6382
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1
    Marker Score: 728
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1
    Marker Score: 1412
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71602
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47826
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.99
    Marker Score: 699
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.98
    Marker Score: 235
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.98
    Marker Score: 473
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30370
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.97
    Marker Score: 665
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.96
    Marker Score: 9542
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.96
    Marker Score: 1243
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 0.96
    Marker Score: 929.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.96
    Marker Score: 12638
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.95
    Marker Score: 6212
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.95
    Marker Score: 1809
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.95
    Marker Score: 1262
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.94
    Marker Score: 843
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.94
    Marker Score: 705
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.94
    Marker Score: 637
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.94
    Marker Score: 378
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2382
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.93
    Marker Score: 844
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.93
    Marker Score: 5677
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.93
    Marker Score: 247
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.93
    Marker Score: 380
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.93
    Marker Score: 425
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.93
    Marker Score: 454

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - Gene name: ALDH9A1 - Ensembl ID: ENSG00000143149 - Pathway ontology: 1-pyrroline dehydrogenase activity, 4-trimethylammoniobutyraldehyde dehydrogenase activity, Aldehyde dehydrogenase (nad+) activity, Aminobutyraldehyde dehydrogenase activity, Carnitine biosynthetic process, Carnitine synthesis, Cellular aldehyde metabolic process, Cytoplasm, Cytosol, Extracellular exosome, Formaldehyde dehydrogenase activity, Glyceraldehyde-3-phosphate dehydrogenase (nad+) (non-phosphorylating) activity, Metabolism, Metabolism of amino acids and derivatives, Protein homotetramerization, Small molecule binding **Pathways and functions:** - ALDH9A1 is involved in the metabolism of aldehydes, which are produced by various metabolic pathways. - It is involved in the detoxification of aldehydes by converting them to less reactive forms. - It is also involved in the synthesis of carnitine, which is an important molecule for energy metabolism. - It is involved in the cellular response to injury by promoting the production of anti-inflammatory cytokines. **Clinical significance:** - Mutations in the ALDH9A1 gene have been linked to several human diseases, including liver disease, cancer, and metabolic disorders. - These mutations can lead to the accumulation of aldehydes in the body, which can damage cells and tissues. - Research on ALDH9A1 is therefore an active area of investigation, with potential implications for the development of new therapies for these diseases.

Genular Protein ID: 3421475646

Symbol: AL9A1_HUMAN

Name: 4-trimethylaminobutyraldehyde dehydrogenase

UniProtKB Accession Codes:

P49189 B2R6X1 B4DXY7 B9EKV4 Q5VV90 Q6LCL1 Q9NZT7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CTD 1 ChEBI 87 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EC 5 EMBL 11 EPD 1 Ensembl 1 GO 13 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 5 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 14 SABIO-RK 1 SASBDB 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8786138

Title: Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression.

PubMed ID: 8786138

DOI: 10.1006/geno.1996.0300

PubMed ID: 10702312

Title: Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis.

PubMed ID: 10702312

DOI: 10.1074/jbc.275.10.7390

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8645224

Title: Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution.

PubMed ID: 8645224

DOI: 10.1042/bj3160317

PubMed ID: 8269919

Title: Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde.

PubMed ID: 8269919

DOI: 10.1111/j.1432-1033.1993.tb18379.x

PubMed ID: 2925663

Title: Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde.

PubMed ID: 2925663

DOI: 10.1016/s0021-9258(18)83802-9

PubMed ID: 1799975

Title: Aldehyde dehydrogenase (EC 1.2.1.3): comparison of subcellular localization of the third isozyme that dehydrogenates gamma-aminobutyraldehyde in rat, guinea pig and human liver.

PubMed ID: 1799975

DOI: 10.1016/0305-0491(91)90382-n

PubMed ID: 2071588

Title: Human aldehyde dehydrogenase. Activity with aldehyde metabolites of monoamines, diamines, and polyamines.

PubMed ID: 2071588

DOI: 10.1016/s0021-9258(18)98796-x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30914451

Title: Kinetic and structural analysis of human ALDH9A1.

PubMed ID: 30914451

DOI: 10.1042/bsr20190558

Sequence Information:

  • Length: 494
  • Mass: 53802
  • Checksum: 1E1CDF910D763BA1
  • Sequence:
    • MSTGTFVVSQ PLNYRGGARV EPADASGTEK AFEPATGRVI ATFTCSGEKE VNLAVQNAKA 
AFKIWSQKSG MERCRILLEA ARIIREREDE IATMECINNG KSIFEARLDI DISWQCLEYY 
AGLAASMAGE HIQLPGGSFG YTRREPLGVC VGIGAWNYPF QIASWKSAPA LACGNAMVFK 
PSPFTPVSAL LLAEIYSEAG VPPGLFNVVQ GGAATGQFLC QHPDVAKVSF TGSVPTGMKI 
MEMSAKGIKP VTLELGGKSP LIIFSDCDMN NAVKGALMAN FLTQGQVCCN GTRVFVQKEI 
LDKFTEEVVK QTQRIKIGDP LLEDTRMGPL INRPHLERVL GFVKVAKEQG AKVLCGGDIY 
VPEDPKLKDG YYMRPCVLTN CRDDMTCVKE EIFGPVMSIL SFDTEAEVLE RANDTTFGLA 
AGVFTRDIQR AHRVVAELQA GTCFINNYNV SPVELPFGGY KKSGFGRENG RVTIEYYSQL 
KTVCVEMGDV ESAF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.