Genular: Defining Cellular Identity and Function

Details for: Vamp2

Gene ID: 22318

Symbol: Vamp2

Ensembl ID: ENSMUSG00000020894

Description: vesicle-associated membrane protein 2

Associated with

Acetylcholine neurotransmitter release cycle
(R-MMU-264642)
Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Cytokine signaling in immune system
(R-MMU-1280215)
Dopamine neurotransmitter release cycle
(R-MMU-212676)
Gaba synthesis, release, reuptake and degradation
(R-MMU-888590)
Glutamate neurotransmitter release cycle
(R-MMU-210500)
Golgi associated vesicle biogenesis
(R-MMU-432722)
Immune system
(R-MMU-168256)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
(R-MMU-9609523)
Lysosome vesicle biogenesis
(R-MMU-432720)
Membrane trafficking
(R-MMU-199991)
Neuronal system
(R-MMU-112316)
Neurotransmitter release cycle
(R-MMU-112310)
Norepinephrine neurotransmitter release cycle
(R-MMU-181430)
Other interleukin signaling
(R-MMU-449836)
Protein localization
(R-MMU-9609507)
Serotonin neurotransmitter release cycle
(R-MMU-181429)
Signaling by interleukins
(R-MMU-449147)
Trans-golgi network vesicle budding
(R-MMU-199992)
Transmission across chemical synapses
(R-MMU-112315)
Calcium-dependent protein binding
(GO:0048306)
Calcium-ion regulated exocytosis
(GO:0017156)
Calmodulin binding
(GO:0005516)
Cellular response to insulin stimulus
(GO:0032869)
Clathrin-coated vesicle
(GO:0030136)
Clathrin-sculpted glutamate transport vesicle membrane
(GO:0060203)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Cytoplasmic vesicle membrane
(GO:0030659)
Eosinophil degranulation
(GO:0043308)
Establishment of localization in cell
(GO:0051649)
Exocytic insertion of neurotransmitter receptor to postsynaptic membrane
(GO:0098967)
Golgi to plasma membrane protein transport
(GO:0043001)
Hormone secretion
(GO:0046879)
Identical protein binding
(GO:0042802)
Lipid binding
(GO:0008289)
Long-term synaptic potentiation
(GO:0060291)
Membrane
(GO:0016020)
Membrane fusion
(GO:0061025)
Molecular adaptor activity
(GO:0060090)
Myosin binding
(GO:0017022)
Neuron projection terminus
(GO:0044306)
Perinuclear region of cytoplasm
(GO:0048471)
Phospholipid binding
(GO:0005543)
Plasma membrane
(GO:0005886)
Positive regulation of intracellular protein transport
(GO:0090316)
Protein-containing complex assembly
(GO:0065003)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Regulated exocytosis
(GO:0045055)
Regulation of calcium ion-dependent exocytosis
(GO:0017158)
Regulation of exocytosis
(GO:0017157)
Regulation of synaptic vesicle recycling
(GO:1903421)
Regulation of vesicle-mediated transport
(GO:0060627)
Response to glucose
(GO:0009749)
Secretory granule
(GO:0030141)
Secretory granule membrane
(GO:0030667)
Snap receptor activity
(GO:0005484)
Snare binding
(GO:0000149)
Snare complex
(GO:0031201)
Snare complex assembly
(GO:0035493)
Storage vacuole
(GO:0000322)
Synapse
(GO:0045202)
Synaptic vesicle
(GO:0008021)
Synaptic vesicle docking
(GO:0016081)
Synaptic vesicle endocytosis
(GO:0048488)
Synaptic vesicle exocytosis
(GO:0016079)
Synaptic vesicle membrane
(GO:0030672)
Synaptobrevin 2-snap-25-syntaxin-1a-complexin i complex
(GO:0070032)
Synaptobrevin 2-snap-25-syntaxin-1a-complexin ii complex
(GO:0070033)
Synaptobrevin 2-snap-25-syntaxin-1a complex
(GO:0070044)
Syntaxin-1 binding
(GO:0017075)
Syntaxin binding
(GO:0019905)
Trans-golgi network
(GO:0005802)
Transmembrane transporter binding
(GO:0044325)
Vesicle
(GO:0031982)
Vesicle-mediated transport
(GO:0016192)
Vesicle fusion
(GO:0006906)
Voltage-gated potassium channel complex
(GO:0008076)
Zymogen granule membrane
(GO:0042589)

Other Information

Proteins

Vesicle-associated membrane protein 2

Genular Protein ID: 1027711428

Symbol: VAMP2_MOUSE

Name: Vesicle-associated membrane protein 2

UniProtKB Accession Codes:

P63044 Q64357

Database IDs:

Citations:

PubMed ID: 9430681

Title: Vesicle-associated membrane protein 2 plays a specific role in the insulin-dependent trafficking of the facilitative glucose transporter GLUT4 in 3T3-L1 adipocytes.

PubMed ID: 9430681

DOI: 10.1074/jbc.273.3.1444

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10413679

Title: Functional characterisation of tetanus and botulinum neurotoxins binding domains.

PubMed ID: 10413679

DOI: 10.1242/jcs.112.16.2715

PubMed ID: 15475946

Title: Synaptobrevin is essential for fast synaptic-vesicle endocytosis.

PubMed ID: 15475946

DOI: 10.1038/ncb1185

PubMed ID: 17313651

Title: WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta.

PubMed ID: 17313651

DOI: 10.1111/j.1742-4658.2007.05702.x

PubMed ID: 17548353

Title: Doc2beta is a novel Munc18c-interacting partner and positive effector of syntaxin 4-mediated exocytosis.

PubMed ID: 17548353

DOI: 10.1074/jbc.m701661200

PubMed ID: 19196426

Title: Sept8 controls the binding of vesicle-associated membrane protein 2 to synaptophysin.

PubMed ID: 19196426

DOI: 10.1111/j.1471-4159.2008.05849.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20057356

Title: Identification of a novel Bves function: regulation of vesicular transport.

PubMed ID: 20057356

DOI: 10.1038/emboj.2009.379

PubMed ID: 20798282

Title: Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.

PubMed ID: 20798282

DOI: 10.1126/science.1195227

PubMed ID: 26406599

Title: SNAREs Interact with Retinal Degeneration Slow and Rod Outer Segment Membrane Protein-1 during Conventional and Unconventional Outer Segment Targeting.

PubMed ID: 26406599

DOI: 10.1371/journal.pone.0138508

PubMed ID: 28821673

Title: UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.

PubMed ID: 28821673

DOI: 10.1523/jneurosci.0338-17.2017

Sequence Information:

Length: 116
Mass: 12691
Checksum: 4A0D0D56B5409D0A
Sequence:

MSATAATVPP AAPAGEGGPP APPPNLTSNR RLQQTQAQVD EVVDIMRVNV DKVLERDQKL 
SELDDRADAL QAGASQFETS AAKLKRKYWW KNLKMMIILG VICAIILIII IVYFST

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Vamp2

Associated with

Other Information

Vesicle-associated membrane protein 2 plays a specific role in the insulin-dependent trafficking of the facilitative glucose transporter GLUT4 in 3T3-L1 adipocytes. PubMed ID: 9430681

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Functional characterisation of tetanus and botulinum neurotoxins binding domains. PubMed ID: 10413679

Synaptobrevin is essential for fast synaptic-vesicle endocytosis. PubMed ID: 15475946

WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta. PubMed ID: 17313651

Doc2beta is a novel Munc18c-interacting partner and positive effector of syntaxin 4-mediated exocytosis. PubMed ID: 17548353

Sept8 controls the binding of vesicle-associated membrane protein 2 to synaptophysin. PubMed ID: 19196426

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Identification of a novel Bves function: regulation of vesicular transport. PubMed ID: 20057356

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro. PubMed ID: 20798282

SNAREs Interact with Retinal Degeneration Slow and Rod Outer Segment Membrane Protein-1 during Conventional and Unconventional Outer Segment Targeting. PubMed ID: 26406599

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans. PubMed ID: 28821673