Genular: Defining Cellular Identity and Function

Details for: Vcl

Gene ID: 22330

Symbol: Vcl

Ensembl ID: ENSMUSG00000021823

Description: vinculin

Associated with

Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Map2k and mapk activation
(R-MMU-5674135)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Muscle contraction
(R-MMU-397014)
Neutrophil degranulation
(R-MMU-6798695)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Raf/map kinase cascade
(R-MMU-5673001)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Signal transduction
(R-MMU-162582)
Smooth muscle contraction
(R-MMU-445355)
Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin filament
(GO:0005884)
Actin filament binding
(GO:0051015)
Adherens junction
(GO:0005912)
Adherens junction assembly
(GO:0034333)
Alpha-catenin binding
(GO:0045294)
Anchoring junction
(GO:0070161)
Apical junction assembly
(GO:0043297)
Axon extension
(GO:0048675)
Beta-catenin binding
(GO:0008013)
Cell-cell contact zone
(GO:0044291)
Cell-cell junction
(GO:0005911)
Cell adhesion
(GO:0007155)
Cell projection
(GO:0042995)
Costamere
(GO:0043034)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Dystroglycan binding
(GO:0002162)
Epithelial cell-cell adhesion
(GO:0090136)
Fascia adherens
(GO:0005916)
Focal adhesion
(GO:0005925)
Intercalated disc
(GO:0014704)
Lamellipodium assembly
(GO:0030032)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Molecular adaptor activity
(GO:0060090)
Morphogenesis of an epithelium
(GO:0002009)
Plasma membrane
(GO:0005886)
Podosome
(GO:0002102)
Podosome ring
(GO:0061826)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein localization to cell surface
(GO:0034394)
Regulation of cell migration
(GO:0030334)
Regulation of establishment of endothelial barrier
(GO:1903140)
Regulation of focal adhesion assembly
(GO:0051893)
Regulation of protein localization to adherens junction
(GO:1904702)
Sarcolemma
(GO:0042383)
Small gtpase binding
(GO:0031267)
Stress fiber
(GO:0001725)
Structural molecule activity
(GO:0005198)
Ubiquitin protein ligase binding
(GO:0031625)
Z disc
(GO:0030018)

Other Information

Proteins

Vinculin

Genular Protein ID: 3816689992

Symbol: VINC_MOUSE

Name: Vinculin

UniProtKB Accession Codes:

Q64727 Q8BP32 Q8BS46 Q922C5 Q922D9

Database IDs:

Citations:

PubMed ID: 7568093

Title: Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion.

PubMed ID: 7568093

DOI: 10.1073/pnas.92.20.9161

PubMed ID: 9280281

Title: Vinculin gene is non-essential in Drosophila melanogaster.

PubMed ID: 9280281

DOI: 10.1016/s0014-5793(97)00901-0

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10085297

Title: Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions.

PubMed ID: 10085297

DOI: 10.1083/jcb.144.5.1001

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18630941

Title: Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.

PubMed ID: 18630941

DOI: 10.1021/pr800223m

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 20599708

Title: Vinculin's C-terminal region facilitates phospholipid membrane insertion.

PubMed ID: 20599708

DOI: 10.1016/j.bbrc.2010.06.094

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20610383

Title: Central region of talin has a unique fold that binds vinculin and actin.

PubMed ID: 20610383

DOI: 10.1074/jbc.m109.095455

PubMed ID: 26359501

Title: Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation.

PubMed ID: 26359501

DOI: 10.1074/jbc.m115.678433

PubMed ID: 27505886

Title: Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity.

PubMed ID: 27505886

DOI: 10.1242/jcs.184622

Sequence Information:

Length: 1066
Mass: 116717
Checksum: 067F1B16A5285859
Sequence:

MPVFHTRTIE SILEPVAQQI SHLVIMHEEG EVDGKAIPDL TAPVAAVQAA VSNLVRVGKE 
TVQTTEDQIL KRDMPPAFIK VENACTKLVQ AAQMLQSDPY SVPARDYLID GSRGILSGTS 
DLLLTFDEAE VRKIIRVCKG ILEYLTVAEV VETMEDLVTY TKNLGPGMTK MAKMIDERQQ 
ELTHQEHRVM LVNSMNTVKE LLPVLISAMK IFVTTKNSKN QGIEEALKNR NFTVEKMSAE 
INEIIRVLQL TSWDEDAWAS KDTEAMKRAL ASIDSKLNQA KGWLRDPNAS PGDAGEQAIR 
QILDEAGKVG ELCAGKERRE ILGTCKMLGQ MTDQVADLRA RGQGASPVAM QKAQQVSQGL 
DVLTAKVENA ARKLEAMTNS KQSIAKKIDA AQNWLADPNG GPEGEEQIRG ALAEARKIAE 
LCDDPKERDD ILRSLGEIAA LTSKLGDLRR QGKGDSPEAR ALAKQVATAL QNLQTKTNRA 
VANSRPAKAA VHLEGKIEQA QRWIDNPTVD DRGVGQAAIR GLVAEGHRLA NVMMGPYRQD 
LLAKCDRVDQ LTAQLADLAA RGEGESPQAR ALASQLQDSL KDLKAQMQEA MTQEVSDVFS 
DTTTPIKLLA VAATAPPDAP NREEVFDERA ANFENHSGRL GATAEKAAAV GTANKSTVEG 
IQASVKTARE LTPQVISAAR ILLRNPGNQA AYEHFETMKN QWIDNVEKMT GLVDEAIDTK 
SLLDASEEAI KKDLDKCKVA MANIQPQMLV AGATSIARRA NRILLVAKRE VENSEDPKFR 
EAVKAASDEL SKTISPMVMD AKAVAGNISD PGLQKSFLDS GYRILGAVAK VREAFQPQEP 
DFPPPPPDLE QLRLTDELAP PKPPLPEGEV PPPRPPPPEE KDEEFPEQKA GEVINQPMMM 
AARQLHDEAR KWSSKGNDII AAAKRMALLM AEMSRLVRGG SGTKRALIQC AKDIAKASDE 
VTRLAKEVAK QCTDKRIRTN LLQVCERIPT ISTQLKILST VKATMLGRTN ISDEESEQAT 
EMLVHNAQNL MQSVKETVRE AEAASIKIRT DAGFTLRWVR KTPWYQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Vcl

Associated with

Other Information

Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion. PubMed ID: 7568093

Vinculin gene is non-essential in Drosophila melanogaster. PubMed ID: 9280281

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Ponsin/SH3P12: an l-afadin- and vinculin-binding protein localized at cell-cell and cell-matrix adherens junctions. PubMed ID: 10085297

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis. PubMed ID: 18630941

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

Vinculin's C-terminal region facilitates phospholipid membrane insertion. PubMed ID: 20599708

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Central region of talin has a unique fold that binds vinculin and actin. PubMed ID: 20610383

Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. PubMed ID: 26359501

Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity. PubMed ID: 27505886