Genular: Defining Cellular Identity and Function

Details for: Vdac1

Gene ID: 22333

Symbol: Vdac1

Ensembl ID: ENSMUSG00000020402

Description: voltage-dependent anion channel 1

Associated with

Autophagy
(R-MMU-9612973)
Deubiquitination
(R-MMU-5688426)
Macroautophagy
(R-MMU-1632852)
Metabolism
(R-MMU-1430728)
Metabolism of proteins
(R-MMU-392499)
Mitophagy
(R-MMU-5205647)
Pink1-prkn mediated mitophagy
(R-MMU-5205685)
Post-translational protein modification
(R-MMU-597592)
Pyruvate metabolism
(R-MMU-70268)
Pyruvate metabolism and citric acid (tca) cycle
(R-MMU-71406)
Selective autophagy
(R-MMU-9663891)
The citric acid (tca) cycle and respiratory electron transport
(R-MMU-1428517)
Ub-specific processing proteases
(R-MMU-5689880)
Acetyl-coa biosynthetic process from pyruvate
(GO:0006086)
Apoptotic process
(GO:0006915)
Behavioral fear response
(GO:0001662)
Ceramide binding
(GO:0097001)
Chemical synaptic transmission
(GO:0007268)
Cholesterol binding
(GO:0015485)
Identical protein binding
(GO:0042802)
Learning
(GO:0007612)
Lipid binding
(GO:0008289)
Membrane
(GO:0016020)
Mitochondrial calcium ion transmembrane transport
(GO:0006851)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial membrane
(GO:0031966)
Mitochondrial nucleoid
(GO:0042645)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrial permeability transition pore complex
(GO:0005757)
Mitochondrion
(GO:0005739)
Monoatomic anion channel activity
(GO:0005253)
Monoatomic anion transmembrane transport
(GO:0098656)
Monoatomic anion transport
(GO:0006820)
Monoatomic ion transport
(GO:0006811)
Myelin sheath
(GO:0043209)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of calcium import into the mitochondrion
(GO:0110099)
Negative regulation of reactive oxygen species metabolic process
(GO:2000378)
Neuron-neuron synaptic transmission
(GO:0007270)
Nucleotide binding
(GO:0000166)
Oxysterol binding
(GO:0008142)
Phosphatidylcholine binding
(GO:0031210)
Plasma membrane
(GO:0005886)
Pore complex
(GO:0046930)
Porin activity
(GO:0015288)
Positive regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
(GO:1905091)
Postsynaptic density membrane
(GO:0098839)
Presynaptic active zone membrane
(GO:0048787)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of mitophagy
(GO:1901524)
Synaptic vesicle
(GO:0008021)
Transmembrane transport
(GO:0055085)
Transmembrane transporter binding
(GO:0044325)
Voltage-gated monoatomic anion channel activity
(GO:0008308)

Other Information

Proteins

Voltage-dependent anion-selective channel protein 1

Genular Protein ID: 1560358237

Symbol: VDAC1_MOUSE

Name: Voltage-dependent anion-selective channel protein 1

UniProtKB Accession Codes:

Q60932 B1ASZ9 Q5SVC6

Database IDs:

Citations:

PubMed ID: 8660977

Title: Isolation, characterization, and mapping of two mouse mitochondrial voltage-dependent anion channel isoforms.

PubMed ID: 8660977

DOI: 10.1006/geno.1996.0193

PubMed ID: 10716730

Title: Evidence for secretory pathway localization of a voltage-dependent anion channel isoform.

PubMed ID: 10716730

DOI: 10.1073/pnas.97.7.3201

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15477379

Title: Voltage-dependent anion channel-1 (VDAC-1) contributes to ATP release and cell volume regulation in murine cells.

PubMed ID: 15477379

DOI: 10.1085/jgp.200409154

PubMed ID: 17208939

Title: Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.

PubMed ID: 17208939

DOI: 10.1074/mcp.m600218-mcp200

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 23576753

Title: Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

PubMed ID: 23576753

DOI: 10.1073/pnas.1302961110

PubMed ID: 25168729

Title: Abeta promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer's disease.

PubMed ID: 25168729

DOI: 10.1016/j.neuroscience.2014.07.079

PubMed ID: 32047033

Title: Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination.

PubMed ID: 32047033

DOI: 10.1073/pnas.1909814117

PubMed ID: 18988731

Title: The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating.

PubMed ID: 18988731

DOI: 10.1073/pnas.0809634105

Sequence Information:

Length: 296
Mass: 32351
Checksum: C0710C1717063B32
Sequence:

MCSFFLVLLL WQNMAVPPTY ADLGKSARDV FTKGYGFGLI KLDLKTKSEN GLEFTSSGSA 
NTETTKVNGS LETKYRWTEY GLTFTEKWNT DNTLGTEITV EDQLARGLKL TFDSSFSPNT 
GKKNAKIKTG YKREHINLGC DVDFDIAGPS IRGALVLGYE GWLAGYQMNF ETSKSRVTQS 
NFAVGYKTDE FQLHTNVNDG TEFGGSIYQK VNKKLETAVN LAWTAGNSNT RFGIAAKYQV 
DPDACFSAKV NNSSLIGLGY TQTLKPGIKL TLSALLDGKN VNAGGHKLGL GLEFQA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Vdac1

Associated with

Other Information

Isolation, characterization, and mapping of two mouse mitochondrial voltage-dependent anion channel isoforms. PubMed ID: 8660977

Evidence for secretory pathway localization of a voltage-dependent anion channel isoform. PubMed ID: 10716730

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Voltage-dependent anion channel-1 (VDAC-1) contributes to ATP release and cell volume regulation in murine cells. PubMed ID: 15477379

Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS. PubMed ID: 17208939

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways. PubMed ID: 23576753

Abeta promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer's disease. PubMed ID: 25168729

Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination. PubMed ID: 32047033

The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating. PubMed ID: 18988731