Genular: Defining Cellular Identity and Function

Details for: Vdr

Gene ID: 22337

Symbol: Vdr

Ensembl ID: ENSMUSG00000022479

Description: vitamin D (1,25-dihydroxyvitamin D3) receptor

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Metabolism of proteins
(R-MMU-392499)
Metabolism of steroids
(R-MMU-8957322)
Nuclear receptor transcription pathway
(R-MMU-383280)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of intracellular receptors
(R-MMU-4090294)
Vitamin d (calciferol) metabolism
(R-MMU-196791)
Animal organ morphogenesis
(GO:0009887)
Apoptotic process involved in mammary gland involution
(GO:0060057)
Apoptotic signaling pathway
(GO:0097190)
Bile acid signaling pathway
(GO:0038183)
Calcitriol binding
(GO:1902098)
Calcium ion transport
(GO:0006816)
Caveola
(GO:0005901)
Cell differentiation
(GO:0030154)
Cell morphogenesis
(GO:0000902)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dense fibrillar component
(GO:0001651)
Dna-binding transcription factor activity
(GO:0003700)
Dna binding
(GO:0003677)
Euchromatin
(GO:0000791)
Heterochromatin
(GO:0000792)
Intestinal absorption
(GO:0050892)
Intracellular calcium ion homeostasis
(GO:0006874)
Lactation
(GO:0007595)
Lithocholic acid binding
(GO:1902121)
Lithocholic acid receptor activity
(GO:0038186)
Mammary gland branching involved in pregnancy
(GO:0060745)
Metal ion binding
(GO:0046872)
Mrna transcription by rna polymerase ii
(GO:0042789)
Multicellular organism development
(GO:0007275)
Negative regulation of bone trabecula formation
(GO:1900155)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of keratinocyte proliferation
(GO:0010839)
Negative regulation of ossification
(GO:0030279)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear matrix
(GO:0016363)
Nuclear receptor activity
(GO:0004879)
Nuclear retinoid x receptor binding
(GO:0046965)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphate ion transmembrane transport
(GO:0035435)
Positive regulation of apoptotic process involved in mammary gland involution
(GO:0060058)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of keratinocyte differentiation
(GO:0045618)
Positive regulation of parathyroid hormone secretion
(GO:2000830)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of vitamin d 24-hydroxylase activity
(GO:0010980)
Positive regulation of vitamin d receptor signaling pathway
(GO:0070564)
Protein binding
(GO:0005515)
Receptor complex
(GO:0043235)
Regulation of calcidiol 1-monooxygenase activity
(GO:0060558)
Regulation of calcium ion transport
(GO:0051924)
Regulation of dna-templated transcription
(GO:0006355)
Response to bile acid
(GO:1903412)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Sequence-specific dna binding
(GO:0043565)
Skeletal system development
(GO:0001501)
T-tubule
(GO:0030315)
Vitamin d binding
(GO:0005499)
Vitamin d receptor signaling pathway
(GO:0070561)
Vitamin d response element binding
(GO:0070644)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Vitamin D3 receptor

Genular Protein ID: 2043375662

Symbol: VDR_MOUSE

Name: Vitamin D3 receptor

UniProtKB Accession Codes:

P48281 Q922X0

Database IDs:

Citations:

PubMed ID: 7835717

Title: Cloning and sequencing of the gene encoding the mouse vitamin D receptor.

PubMed ID: 7835717

DOI: 10.1016/0378-1119(94)00735-b

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12016314

Title: Vitamin D receptor as an intestinal bile acid sensor.

PubMed ID: 12016314

DOI: 10.1126/science.1070477

PubMed ID: 14528024

Title: Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system.

PubMed ID: 14528024

DOI: 10.1210/me.2003-0048

PubMed ID: 28751364

Title: Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity.

PubMed ID: 28751364

DOI: 10.1073/pnas.1704955114

PubMed ID: 32354638

Title: Lithocholic acid increases intestinal phosphate and calcium absorption in a vitamin D receptor dependent but transcellular pathway independent manner.

PubMed ID: 32354638

DOI: 10.1016/j.kint.2020.01.032

Sequence Information:

Length: 422
Mass: 47834
Checksum: 4614DD4A129F2732
Sequence:

MEAMAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR SMKRKALFTC 
PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV QRKREMIMKR KEEEALKDSL 
RPKLSEEQQH IIAILLDAHH KTYDPTYADF RDFRPPIRAD VSTGSYSPRP TLSFSGDSSS 
NSDLYTPSLD MMEPASFSTM DLNEEGSDDP SVTLDLSPLS MLPHLADLVS YSIQKVIGFA 
KMIPGFRDLT SDDQIVLLKS SAIEVIMLRS NQSFTLDDMS WDCGSQDYKY DITDVSRAGH 
TLELIEPLIK FQVGLKKLNL HEEEHVLLMA ICIVSPDRPG VQDAKLVEAI QDRLSNTLQT 
YIRCRHPPPG SHQLYAKMIQ KLADLRSLNE EHSKQYRSLS FQPENSMKLT PLVLEVFGNE 
IS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Vdr

Associated with

Other Information

Cloning and sequencing of the gene encoding the mouse vitamin D receptor. PubMed ID: 7835717

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Vitamin D receptor as an intestinal bile acid sensor. PubMed ID: 12016314

Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system. PubMed ID: 14528024

Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity. PubMed ID: 28751364

Lithocholic acid increases intestinal phosphate and calcium absorption in a vitamin D receptor dependent but transcellular pathway independent manner. PubMed ID: 32354638