Genular: Defining Cellular Identity and Function

Details for: Vegfa

Gene ID: 22339

Symbol: Vegfa

Ensembl ID: ENSMUSG00000023951

Description: vascular endothelial growth factor A

Associated with

Hemostasis
(R-MMU-109582)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by vegf
(R-MMU-194138)
Signal transduction
(R-MMU-162582)
Vegfa-vegfr2 pathway
(R-MMU-4420097)
Vegf binds to vegfr leading to receptor dimerization
(R-MMU-195399)
Vegf ligand-receptor interactions
(R-MMU-194313)
Vegfr2 mediated cell proliferation
(R-MMU-5218921)
Activation of protein kinase activity
(GO:0032147)
Angiogenesis
(GO:0001525)
Apoptotic process
(GO:0006915)
Basophil chemotaxis
(GO:0002575)
Blood vessel development
(GO:0001568)
Blood vessel remodeling
(GO:0001974)
Branching involved in blood vessel morphogenesis
(GO:0001569)
Cell differentiation
(GO:0030154)
Cell migration
(GO:0016477)
Cell migration involved in sprouting angiogenesis
(GO:0002042)
Cell population proliferation
(GO:0008283)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Chemoattractant activity
(GO:0042056)
Coronary vein morphogenesis
(GO:0003169)
Cytokine activity
(GO:0005125)
Endothelial cell chemotaxis
(GO:0035767)
Endothelial cell proliferation
(GO:0001935)
Epithelial cell differentiation
(GO:0030855)
Epithelial cell maturation
(GO:0002070)
Fibronectin binding
(GO:0001968)
Growth factor activity
(GO:0008083)
Growth factor binding
(GO:0019838)
Heart morphogenesis
(GO:0003007)
Heparin binding
(GO:0008201)
Identical protein binding
(GO:0042802)
In utero embryonic development
(GO:0001701)
Kidney development
(GO:0001822)
Lactation
(GO:0007595)
Lung development
(GO:0030324)
Lymphangiogenesis
(GO:0001946)
Lymph vessel morphogenesis
(GO:0036303)
Macrophage differentiation
(GO:0030225)
Mesoderm development
(GO:0007498)
Monocyte differentiation
(GO:0030224)
Multicellular organism development
(GO:0007275)
Negative regulation of cell-cell adhesion
(GO:0022408)
Negative regulation of epithelial to mesenchymal transition
(GO:0010719)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Neuroblast proliferation
(GO:0007405)
Neuropilin binding
(GO:0038191)
Outflow tract morphogenesis
(GO:0003151)
Ovarian follicle development
(GO:0001541)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Platelet-derived growth factor receptor binding
(GO:0005161)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell migration by vascular endothelial growth factor signaling pathway
(GO:0038089)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cell proliferation by vegf-activated platelet derived growth factor receptor signaling pathway
(GO:0038091)
Positive regulation of endothelial cell chemotaxis by vegf-activated vascular endothelial growth factor receptor signaling pathway
(GO:0038033)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neuroblast proliferation
(GO:0002052)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of protein autophosphorylation
(GO:0031954)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of receptor internalization
(GO:0002092)
Positive regulation of signal transduction
(GO:0009967)
Post-embryonic camera-type eye development
(GO:0031077)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Regulation of cell shape
(GO:0008360)
Regulation of nitric oxide mediated signal transduction
(GO:0010749)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to hypoxia
(GO:0001666)
Retinal ganglion cell axon guidance
(GO:0031290)
Sprouting angiogenesis
(GO:0002040)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)
Tube formation
(GO:0035148)
Vascular endothelial growth factor receptor-2 signaling pathway
(GO:0036324)
Vascular endothelial growth factor receptor 1 binding
(GO:0043183)
Vascular endothelial growth factor receptor 2 binding
(GO:0043184)
Vascular endothelial growth factor receptor binding
(GO:0005172)
Vascular endothelial growth factor signaling pathway
(GO:0038084)
Vasculature development
(GO:0001944)
Vegf-activated neuropilin signaling pathway
(GO:0038190)

Other Information

Proteins

Vascular endothelial growth factor A, long form

Genular Protein ID: 875130005

Symbol: VEGFA_MOUSE

Name: Vascular endothelial growth factor A, long form

UniProtKB Accession Codes:

Q00731 F8WH81 O70123 Q66S31 Q6GT23 Q6WZL9

Database IDs:

Citations:

PubMed ID: 1592003

Title: Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation.

PubMed ID: 1592003

DOI: 10.1242/dev.114.2.521

PubMed ID: 1644816

Title: Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways.

PubMed ID: 1644816

DOI: 10.1016/s0021-9258(18)42003-0

PubMed ID: 9446618

Title: A novel alternatively spliced form of murine vascular endothelial growth factor, VEGF 115.

PubMed ID: 9446618

DOI: 10.1074/jbc.273.5.3033

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8632007

Title: The mouse gene for vascular endothelial growth factor. Genomic structure, definition of the transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequences.

PubMed ID: 8632007

DOI: 10.1074/jbc.271.7.3877

PubMed ID: 10878616

Title: Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution.

PubMed ID: 10878616

DOI: 10.1002/1097-0177(200007)218:3<507::aid-dvdy1012>3.0.co;2-5

PubMed ID: 16293765

Title: Embryonic lethality in Dear gene-deficient mice: new player in angiogenesis.

PubMed ID: 16293765

DOI: 10.1152/physiolgenomics.00144.2005

PubMed ID: 16259067

Title: The regulators of VEGF expression in mouse ovaries.

PubMed ID: 16259067

DOI: 10.3349/ymj.2005.46.5.679

PubMed ID: 26503042

Title: CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.

PubMed ID: 26503042

DOI: 10.1038/nature15510

PubMed ID: 26789244

Title: Corrigendum: CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase.

PubMed ID: 26789244

DOI: 10.1038/nature16499

PubMed ID: 35455969

Title: N-VEGF, the Autoregulatory Arm of VEGF-A.

PubMed ID: 35455969

DOI: 10.3390/cells11081289

Sequence Information:

Length: 392
Mass: 43131
Checksum: A27A7A6A18AF138A
Sequence:

MTDRQTDTAP SPSAHLLAGG LPTVDAAASR EEPKPAPGGG VEGVGARGIA RKLFVQLLGS 
SRSVVAVVCA AGDKPIGAGR SASSGLEKPG PEKRGEEEKE EERGPQWALG SQEPSSWTGE 
AAVCADSAPA ARAPQAPARA SVPEGRGARQ GAQESGLPRS PSRRGSASRA GPGRASETMN 
FLLSWVHWTL ALLLYLHHAK WSQAAPTTEG EQKSHEVIKF MDVYQRSYCR PIETLVDIFQ 
EYPDEIEYIF KPSCVPLMRC AGCCNDEALE CVPTSESNIT MQIMRIKPHQ SQHIGEMSFL 
QHSRCECRPK KDRTKPEKKS VRGKGKGQKR KRKKSRFKSW SVHCEPCSER RKHLFVQDPQ 
TCKCSCKNTD SRCKARQLEL NERTCRCDKP RR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Vegfa

Associated with

Other Information

Expression of vascular endothelial growth factor during embryonic angiogenesis and endothelial cell differentiation. PubMed ID: 1592003

Vascular endothelial growth factor. Regulation by cell differentiation and activated second messenger pathways. PubMed ID: 1644816

A novel alternatively spliced form of murine vascular endothelial growth factor, VEGF 115. PubMed ID: 9446618

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The mouse gene for vascular endothelial growth factor. Genomic structure, definition of the transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequences. PubMed ID: 8632007

Regulation of VEGF and VEGF receptor expression in the rodent mammary gland during pregnancy, lactation, and involution. PubMed ID: 10878616

Embryonic lethality in Dear gene-deficient mice: new player in angiogenesis. PubMed ID: 16293765

The regulators of VEGF expression in mouse ovaries. PubMed ID: 16259067

CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. PubMed ID: 26503042

Corrigendum: CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase. PubMed ID: 26789244

N-VEGF, the Autoregulatory Arm of VEGF-A. PubMed ID: 35455969