Genular: Defining Cellular Identity and Function

Details for: Vhl

Gene ID: 22346

Symbol: Vhl

Ensembl ID: ENSMUSG00000033933

Description: von Hippel-Lindau tumor suppressor

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to hypoxia
(R-MMU-1234174)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Immune system
(R-MMU-168256)
Metabolism of proteins
(R-MMU-392499)
Neddylation
(R-MMU-8951664)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-MMU-1234176)
Post-translational protein modification
(R-MMU-597592)
Rhobtb3 atpase cycle
(R-MMU-9706019)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of ubiquitinylation proteins
(R-MMU-3232142)
Angiogenesis
(GO:0001525)
Blood vessel endothelial cell migration
(GO:0043534)
Camera-type eye morphogenesis
(GO:0048593)
Ciliary body morphogenesis
(GO:0061073)
Cilium
(GO:0005929)
Cul2-ring ubiquitin ligase complex
(GO:0031462)
Cytoplasm
(GO:0005737)
Dna-binding transcription factor binding
(GO:0140297)
Endoplasmic reticulum
(GO:0005783)
Endothelial cell differentiation
(GO:0045446)
Enzyme binding
(GO:0019899)
Extracellular matrix organization
(GO:0030198)
Eye pigmentation
(GO:0048069)
Glutamatergic synapse
(GO:0098978)
Homeostasis of number of retina cells
(GO:0048877)
Hypoxia-inducible factor-1alpha signaling pathway
(GO:0097411)
Intracellular non-membrane-bounded organelle
(GO:0043232)
Iris morphogenesis
(GO:0061072)
Melanin metabolic process
(GO:0006582)
Membrane
(GO:0016020)
Molecular adaptor activity
(GO:0060090)
Negative regulation of endothelial cell differentiation
(GO:0045602)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of hypoxia-inducible factor-1alpha signaling pathway
(GO:1902072)
Negative regulation of thymocyte apoptotic process
(GO:0070244)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron differentiation
(GO:0030182)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pancreatic a cell differentiation
(GO:0003310)
Plasma membrane
(GO:0005886)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Postsynaptic density
(GO:0014069)
Proteasomal protein catabolic process
(GO:0010498)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein transport
(GO:0015031)
Protein ubiquitination
(GO:0016567)
Regulation of apoptotic signaling pathway
(GO:2001233)
Regulation of catecholamine metabolic process
(GO:0042069)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of postsynapse organization
(GO:0099175)
Regulation of protein localization
(GO:0032880)
Regulation of thymocyte apoptotic process
(GO:0070243)
Regulation protein catabolic process at postsynapse
(GO:0140252)
Response to hypoxia
(GO:0001666)
Transcription elongation factor activity
(GO:0003711)
Type b pancreatic cell differentiation
(GO:0003309)
Ubiquitin ligase-substrate adaptor activity
(GO:1990756)
Vcb complex
(GO:0030891)

Other Information

Proteins

von Hippel-Lindau disease tumor suppressor

Genular Protein ID: 3649450706

Symbol: VHL_MOUSE

Name: von Hippel-Lindau disease tumor suppressor

UniProtKB Accession Codes:

P40338

Database IDs:

Citations:

PubMed ID: 8521303

Title: Expression of the Von Hippel-Lindau tumor suppressor gene, VHL, in human fetal kidney and during mouse embryogenesis.

PubMed ID: 8521303

DOI: 10.1007/bf03401583

PubMed ID: 7850784

Title: Cloning and characterization of a mouse gene with homology to the human von Hippel-Lindau disease tumor suppressor gene: implications for the potential organization of the human von Hippel-Lindau disease gene.

PubMed ID: 7850784

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 181
Mass: 20770
Checksum: AE8B2E8DDD3EE987
Sequence:

MPRKAASPEE AAGEPGPEEM EAGRPRPVLR SVNSREPSQV IFCNRSPRVV LPLWLNFDGE 
PQPYPILPPG TGRRIHSYRG HLWLFRDAGT HDGLLVNQTE LFVPSLNVDG QPIFANITLP 
VYTLKERCLQ VVRSLVKPEN YRRLDIVRSL YEDLEDYPSV RKDIQRLSQE HLESQHLEEE 
P

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Vhl

Associated with

Other Information

Expression of the Von Hippel-Lindau tumor suppressor gene, VHL, in human fetal kidney and during mouse embryogenesis. PubMed ID: 8521303

Cloning and characterization of a mouse gene with homology to the human von Hippel-Lindau disease tumor suppressor gene: implications for the potential organization of the human von Hippel-Lindau disease gene. PubMed ID: 7850784

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Database document:

PubMed ID: 8521303

PubMed ID: 7850784

PubMed ID: 15489334

PubMed ID: 21183079