Genular: Defining Cellular Identity and Function

Details for: Vil1

Gene ID: 22349

Symbol: Vil1

Ensembl ID: ENSMUSG00000026175

Description: villin 1

Associated with

Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin filament binding
(GO:0051015)
Actin filament bundle
(GO:0032432)
Actin filament capping
(GO:0051693)
Actin filament depolymerization
(GO:0030042)
Actin filament polymerization
(GO:0030041)
Actin filament severing
(GO:0051014)
Actin polymerization or depolymerization
(GO:0008154)
Apoptotic process
(GO:0006915)
Barbed-end actin filament capping
(GO:0051016)
Brush border
(GO:0005903)
Calcium ion binding
(GO:0005509)
Cell projection
(GO:0042995)
Cellular response to epidermal growth factor stimulus
(GO:0071364)
Cellular response to hepatocyte growth factor stimulus
(GO:0035729)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(GO:0043027)
Cytoplasm
(GO:0005737)
Cytoplasmic actin-based contraction involved in cell motility
(GO:0060327)
Cytoskeleton
(GO:0005856)
Cytoskeleton organization
(GO:0007010)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Filopodium
(GO:0030175)
Filopodium tip
(GO:0032433)
Identical protein binding
(GO:0042802)
Intestinal d-glucose absorption
(GO:0001951)
Lamellipodium
(GO:0030027)
Lysophosphatidic acid binding
(GO:0035727)
Metal ion binding
(GO:0046872)
Microvillus
(GO:0005902)
Microvillus assembly
(GO:0030033)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Plasma membrane
(GO:0005886)
Positive regulation of actin filament bundle assembly
(GO:0032233)
Positive regulation of actin filament depolymerization
(GO:0030836)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of epithelial cell migration
(GO:0010634)
Positive regulation of lamellipodium morphogenesis
(GO:2000394)
Positive regulation of multicellular organism growth
(GO:0040018)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of actin nucleation
(GO:0051125)
Regulation of cell shape
(GO:0008360)
Regulation of lamellipodium morphogenesis
(GO:2000392)
Regulation of microvillus length
(GO:0032532)
Regulation of wound healing
(GO:0061041)
Response to bacterium
(GO:0009617)
Ruffle
(GO:0001726)
Terminal web assembly
(GO:1902896)

Other Information

Proteins

Villin-1
Q8CEJ4_MOUSE

Genular Protein ID: 2570556193

Symbol: VILI_MOUSE

Name: Villin-1

UniProtKB Accession Codes:

Q62468 Q149B6 Q91WH4

Database IDs:

Citations:

PubMed ID: 1601186

Title: Expression and localization of villin, fimbrin, and myosin I in differentiating mouse F9 teratocarcinoma cells.

PubMed ID: 1601186

DOI: 10.1016/0012-1606(92)90195-m

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10459016

Title: In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush borders.

PubMed ID: 10459016

DOI: 10.1083/jcb.146.4.819

PubMed ID: 12937273

Title: Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells.

PubMed ID: 12937273

DOI: 10.1091/mbc.e03-02-0091

PubMed ID: 16008578

Title: Shigella flexneri infection is dependent on villin in the mouse intestine and in primary cultures of intestinal epithelial cells.

PubMed ID: 16008578

DOI: 10.1111/j.1462-5822.2005.00535.x

PubMed ID: 18198174

Title: A novel role for villin in intestinal epithelial cell survival and homeostasis.

PubMed ID: 18198174

DOI: 10.1074/jbc.m707962200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 827
Mass: 92775
Checksum: 15601DFBA04B500E
Sequence:

MTKLNAQVKG SLNITTPGIQ IWRIEAMQMV PVPSSTFGSF FDGDCYVVLA IHKTSSTLSY 
DIHYWIGQDS SQDEQGAAAI YTTQMDDYLK GRAVQHREVQ GNESETFRSY FKQGLVIRKG 
GVASGMKHVE TNSCDVQRLL HVKGKRNVLA GEVEMSWKSF NRGDVFLLDL GKLIIQWNGP 
ESNRMERLRG MALAKEIRDQ ERGGRTYVGV VDGEKEGDSP QLMAIMNHVL GPRKELKAAI 
SDSVVEPAAK AALKLYHVSD SEGKLVVREV ATRPLTQDLL KHEDCYILDQ GGLKIFVWKG 
KNANAQERSG AMSQALNFIK AKQYPPSTQV EVQNDGAESP IFQQLFQKWT VPNRTSGLGK 
THTVGSVAKV EQVKFDALTM HVQPQVAAQQ KMVDDGSGEV QVWRIEDLEL VPVESKWLGH 
FYGGDCYLLL YTYLIGEKQH YLLYIWQGSQ ASQDEIAASA YQAVLLDQKY NDEPVQIRVT 
MGKEPPHLMS IFKGRMVVYQ GGTSRKNNLE PVPSTRLFQV RGTNADNTKA FEVTARATSL 
NSNDVFILKT PSCCYLWCGK GCSGDEREMA KMVADTISRT EKQVVVEGQE PANFWMALGG 
KAPYANTKRL QEENQVITPR LFECSNQTGR FLATEIFDFN QDDLEEEDVF LLDVWDQVFF 
WIGKHANEEE KKAAATTVQE YLKTHPGNRD LETPIIVVKQ GHEPPTFTGW FLAWDPFKWS 
NTKSYDDLKA ELGNSGDWSQ IADEVMSPKV DVFTANTSLS SGPLPTFPLE QLVNKSVEDL 
PEGVDPSRKE EHLSTEDFTR ALGMTPAAFS ALPRWKQQNI KKEKGLF

Genular Protein ID: 2524230880

Symbol: Q8CEJ4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8CEJ4

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 827
Mass: 92834
Checksum: 9B8DF443CAFC2747
Sequence:

MTKLNAQVKG SLNITTPGIQ IWRIEAMQMV RVPSSTFGSF FDGDCYVVLA IHKTSSTLSY 
DIHYWIGQDS SQDEQGAAAI YTTQMDDYLK GRAVQHREVQ GNESETFRSY FKQGLVIRKG 
GVASGMKHVE TNSCDVQRLL HVKGKRNVLA GEVEMSWKSF NRGDVFLLDL GKLIIQWNGP 
ESNRMERLRG MALAKEIRDQ ERGGRTYVGV VDGEKEGDSP QLMAIMNHVL GPRKELKAAI 
SDSVVEPAAK AALKLYHVSD SEGKLVVREV ATRPLTQDLL KHEDCYILDQ GGLKIFVWKG 
KNANAQERSG AMSQALNFIK AKQYPPSTQV EVQNDGAESP IFQQLFQKWT VPNRTSGLGK 
THTVGSVAKV EQVKFDALTM HVQPQVAAQQ KMVDDGSGEV QVWRIEDLEL VPVESKWLGH 
FYGGDCYLLL YTYLIGEKQH YLLYIWQGSQ ASQDEIAASA YQAVLLDQKY NDEPVQIRVT 
MGKEPPHLMS IFKGRMVVYQ GGTSRKNNLE PVPSTRLFQV RGTNADNTKA FEVTARATSL 
NSNDVFILKT PSCCYLWCGK GCSGDEREMA KMVADTISRT EKQVVVEGQE PANFWMALGG 
KAPYANTKRL QEENQVITPR LFECSNQTGR FLATEIFDFN QDDLEEEDVF LLDVWDQVFF 
WIGKHANEEE KKAAATTVQE YLKTHPGNRD LETPIIVVKQ GHEPPTFTGW FLAWDPFKWS 
NTKSYDDLKA ELGNSGDWSQ IADEVMSPKV DVFTANTSLS SGPLPTFPLE QLVNKSVEDL 
PEGVDPSRKE EHLSTEDFTR ALGMTPAAFS ALPRWKQQNI KKEKGLF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Vil1

Associated with

Other Information

Expression and localization of villin, fimbrin, and myosin I in differentiating mouse F9 teratocarcinoma cells. PubMed ID: 1601186

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

In vivo, villin is required for Ca(2+)-dependent F-actin disruption in intestinal brush borders. PubMed ID: 10459016

Villin enhances hepatocyte growth factor-induced actin cytoskeleton remodeling in epithelial cells. PubMed ID: 12937273

Shigella flexneri infection is dependent on villin in the mouse intestine and in primary cultures of intestinal epithelial cells. PubMed ID: 16008578

A novel role for villin in intestinal epithelial cell survival and homeostasis. PubMed ID: 18198174

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073